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Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity.
Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L. Zhang YJ, et al. Among authors: gonzales pk. Science. 2019 Feb 15;363(6428):eaav2606. doi: 10.1126/science.aav2606. Science. 2019. PMID: 30765536 Free PMC article.
Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients.
Prudencio M, Gonzales PK, Cook CN, Gendron TF, Daughrity LM, Song Y, Ebbert MTW, van Blitterswijk M, Zhang YJ, Jansen-West K, Baker MC, DeTure M, Rademakers R, Boylan KB, Dickson DW, Petrucelli L, Link CD. Prudencio M, et al. Among authors: gonzales pk. Hum Mol Genet. 2017 Sep 1;26(17):3421-3431. doi: 10.1093/hmg/ddx233. Hum Mol Genet. 2017. PMID: 28637276 Free PMC article.
Neurodegeneration, Heterochromatin, and Double-Stranded RNA.
Saldi TK, Gonzales PK, LaRocca TJ, Link CD. Saldi TK, et al. Among authors: gonzales pk. J Exp Neurosci. 2019 Feb 14;13:1179069519830697. doi: 10.1177/1179069519830697. eCollection 2019. J Exp Neurosci. 2019. PMID: 30792577 Free PMC article. Review.
Higher Viral Load Drives Infrequent Severe Acute Respiratory Syndrome Coronavirus 2 Transmission Between Asymptomatic Residence Hall Roommates.
Bjorkman KK, Saldi TK, Lasda E, Bauer LC, Kovarik J, Gonzales PK, Fink MR, Tat KL, Hager CR, Davis JC, Ozeroff CD, Brisson GR, Larremore DB, Leinwand LA, McQueen MB, Parker R. Bjorkman KK, et al. Among authors: gonzales pk. J Infect Dis. 2021 Oct 28;224(8):1316-1324. doi: 10.1093/infdis/jiab386. J Infect Dis. 2021. PMID: 34302469 Free PMC article.
16 results