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Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers.
Wang J, Suh JM, Woo BJ, Navickas A, Garcia K, Yin K, Fish L, Cavazos T, Hänisch B, Markett D, Yu S, Hirst G, Brown-Swigart L, Esserman LJ, van 't Veer LJ, Goodarzi H. Wang J, et al. Among authors: goodarzi h. bioRxiv [Preprint]. 2024 Mar 21:2024.03.19.585748. doi: 10.1101/2024.03.19.585748. bioRxiv. 2024. PMID: 38562907 Free PMC article. Preprint.
Revealing the grammar of small RNA secretion using interpretable machine learning.
Zirak B, Naghipourfar M, Saberi A, Pouyabahar D, Zarezadeh A, Luo L, Fish L, Huh D, Navickas A, Sharifi-Zarchi A, Goodarzi H. Zirak B, et al. Among authors: goodarzi h. Cell Genom. 2024 Apr 10;4(4):100522. doi: 10.1016/j.xgen.2024.100522. Epub 2024 Mar 8. Cell Genom. 2024. PMID: 38460515 Free article.
Functional microRNA-targeting drug discovery by graph-based deep learning.
Keshavarzi Arshadi A, Salem M, Karner H, Garcia K, Arab A, Yuan JS, Goodarzi H. Keshavarzi Arshadi A, et al. Among authors: goodarzi h. Patterns (N Y). 2024 Jan 3;5(1):100909. doi: 10.1016/j.patter.2023.100909. eCollection 2024 Jan 12. Patterns (N Y). 2024. PMID: 38264717 Free PMC article.
Single-nucleus multiomic atlas of frontal cortex in amyotrophic lateral sclerosis with a deep learning-based decoding of alternative polyadenylation mechanisms.
McKeever PM, Sababi AM, Sharma R, Khuu N, Xu Z, Shen SY, Xiao S, McGoldrick P, Orouji E, Ketela T, Sato C, Moreno D, Visanji N, Kovacs GG, Keith J, Zinman L, Rogaeva E, Goodarzi H, Bader GD, Robertson J. McKeever PM, et al. Among authors: goodarzi h. bioRxiv [Preprint]. 2023 Dec 23:2023.12.22.573083. doi: 10.1101/2023.12.22.573083. bioRxiv. 2023. PMID: 38187588 Free PMC article. Preprint.
ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway in breast cancer.
Wang S, Böhnert V, Joseph AJ, Sudaryo V, Skariah G, Swinderman JT, Yu FB, Subramanyam V, Wolf DM, Lyu X, Gilbert LA, Van't Veer LJ, Goodarzi H, Li L. Wang S, et al. Among authors: goodarzi h. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2313693120. doi: 10.1073/pnas.2313693120. Epub 2023 Dec 20. Proc Natl Acad Sci U S A. 2023. PMID: 38117852 Free PMC article.
RPL22 is a tumor suppressor in MSI-high cancers and a key splicing regulator of MDM4.
Weinstein HNW, Hu K, Fish L, Chen YA, Allegakoen P, Hui KSF, Pham JH, Baco MB, Song H, Giacomelli AO, Vazquez F, Ghandi M, Goodarzi H, Huang FW. Weinstein HNW, et al. Among authors: goodarzi h. bioRxiv [Preprint]. 2023 Dec 10:2023.12.10.570873. doi: 10.1101/2023.12.10.570873. bioRxiv. 2023. PMID: 38106152 Free PMC article. Preprint.
Nucleosome density shapes kilobase-scale regulation by a mammalian chromatin remodeler.
Abdulhay NJ, Hsieh LJ, McNally CP, Ostrowski MS, Moore CM, Ketavarapu M, Kasinathan S, Nanda AS, Wu K, Chio US, Zhou Z, Goodarzi H, Narlikar GJ, Ramani V. Abdulhay NJ, et al. Among authors: goodarzi h. Nat Struct Mol Biol. 2023 Oct;30(10):1571-1581. doi: 10.1038/s41594-023-01093-6. Epub 2023 Sep 11. Nat Struct Mol Biol. 2023. PMID: 37696956 Free PMC article.
167 results