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Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome.
Tovy A, Rosas C, Gaikwad AS, Medrano G, Zhang L, Reyes JM, Huang YH, Arakawa T, Kurtz K, Conneely SE, Guzman AG, Aguilar R, Gao A, Chen CW, Kim JJ, Carter MT, Lasa-Aranzasti A, Valenzuela I, Van Maldergem L, Brunetti L, Hicks MJ, Marcogliese AN, Goodell MA, Rau RE. Tovy A, et al. Among authors: goodell ma. Haematologica. 2022 Apr 1;107(4):887-898. doi: 10.3324/haematol.2021.278990. Haematologica. 2022. PMID: 34092059 Free PMC article.
Dnmt3a is essential for hematopoietic stem cell differentiation.
Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, Vasanthakumar A, Gu H, Xi Y, Liang S, Lu Y, Darlington GJ, Meissner A, Issa JP, Godley LA, Li W, Goodell MA. Challen GA, et al. Among authors: goodell ma. Nat Genet. 2011 Dec 4;44(1):23-31. doi: 10.1038/ng.1009. Nat Genet. 2011. PMID: 22138693 Free PMC article.
Large conserved domains of low DNA methylation maintained by Dnmt3a.
Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim SB, Yang L, Ko M, Chen R, Göttgens B, Lee JS, Gunaratne P, Godley LA, Darlington GJ, Rao A, Li W, Goodell MA. Jeong M, et al. Among authors: goodell ma. Nat Genet. 2014 Jan;46(1):17-23. doi: 10.1038/ng.2836. Epub 2013 Nov 24. Nat Genet. 2014. PMID: 24270360 Free PMC article.
Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells.
Challen GA, Sun D, Mayle A, Jeong M, Luo M, Rodriguez B, Mallaney C, Celik H, Yang L, Xia Z, Cullen S, Berg J, Zheng Y, Darlington GJ, Li W, Goodell MA. Challen GA, et al. Among authors: goodell ma. Cell Stem Cell. 2014 Sep 4;15(3):350-364. doi: 10.1016/j.stem.2014.06.018. Epub 2014 Aug 14. Cell Stem Cell. 2014. PMID: 25130491 Free PMC article.
DNMT3A in haematological malignancies.
Yang L, Rau R, Goodell MA. Yang L, et al. Among authors: goodell ma. Nat Rev Cancer. 2015 Mar;15(3):152-65. doi: 10.1038/nrc3895. Epub 2015 Feb 19. Nat Rev Cancer. 2015. PMID: 25693834 Free PMC article. Review.
Noncoding Regulatory RNAs in Hematopoiesis.
Jeong M, Goodell MA. Jeong M, et al. Among authors: goodell ma. Curr Top Dev Biol. 2016;118:245-70. doi: 10.1016/bs.ctdb.2016.01.006. Epub 2016 Feb 23. Curr Top Dev Biol. 2016. PMID: 27137659 Review.
DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.
Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Gottgens B, Lee JS, Rau R, Li W, Goodell MA. Yang L, et al. Among authors: goodell ma. Cancer Cell. 2016 Jun 13;29(6):922-934. doi: 10.1016/j.ccell.2016.05.003. Cancer Cell. 2016. PMID: 27300438 Free PMC article.
195 results