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Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli.
Napolitano MG, Landon M, Gregg CJ, Lajoie MJ, Govindarajan L, Mosberg JA, Kuznetsov G, Goodman DB, Vargas-Rodriguez O, Isaacs FJ, Söll D, Church GM. Napolitano MG, et al. Among authors: goodman db. Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5588-97. doi: 10.1073/pnas.1605856113. Epub 2016 Sep 6. Proc Natl Acad Sci U S A. 2016. PMID: 27601680 Free PMC article.
Design, synthesis, and testing toward a 57-codon genome.
Ostrov N, Landon M, Guell M, Kuznetsov G, Teramoto J, Cervantes N, Zhou M, Singh K, Napolitano MG, Moosburner M, Shrock E, Pruitt BW, Conway N, Goodman DB, Gardner CL, Tyree G, Gonzales A, Wanner BL, Norville JE, Lajoie MJ, Church GM. Ostrov N, et al. Among authors: goodman db. Science. 2016 Aug 19;353(6301):819-22. doi: 10.1126/science.aaf3639. Science. 2016. PMID: 27540174
Genomically recoded organisms expand biological functions.
Lajoie MJ, Rovner AJ, Goodman DB, Aerni HR, Haimovich AD, Kuznetsov G, Mercer JA, Wang HH, Carr PA, Mosberg JA, Rohland N, Schultz PG, Jacobson JM, Rinehart J, Church GM, Isaacs FJ. Lajoie MJ, et al. Among authors: goodman db. Science. 2013 Oct 18;342(6156):357-60. doi: 10.1126/science.1241459. Science. 2013. PMID: 24136966 Free PMC article.
Precise manipulation of chromosomes in vivo enables genome-wide codon replacement.
Isaacs FJ, Carr PA, Wang HH, Lajoie MJ, Sterling B, Kraal L, Tolonen AC, Gianoulis TA, Goodman DB, Reppas NB, Emig CJ, Bang D, Hwang SJ, Jewett MC, Jacobson JM, Church GM. Isaacs FJ, et al. Among authors: goodman db. Science. 2011 Jul 15;333(6040):348-53. doi: 10.1126/science.1205822. Science. 2011. PMID: 21764749 Free PMC article.
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