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Curing HIV: Seeking to Target and Clear Persistent Infection.
Margolis DM, Archin NM, Cohen MS, Eron JJ, Ferrari G, Garcia JV, Gay CL, Goonetilleke N, Joseph SB, Swanstrom R, Turner AW, Wahl A. Margolis DM, et al. Among authors: goonetilleke n. Cell. 2020 Apr 2;181(1):189-206. doi: 10.1016/j.cell.2020.03.005. Epub 2020 Mar 26. Cell. 2020. PMID: 32220311 Free PMC article. Review.
The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation.
Abrahams MR, Joseph SB, Garrett N, Tyers L, Moeser M, Archin N, Council OD, Matten D, Zhou S, Doolabh D, Anthony C, Goonetilleke N, Karim SA, Margolis DM, Pond SK, Williamson C, Swanstrom R. Abrahams MR, et al. Among authors: goonetilleke n. Sci Transl Med. 2019 Oct 9;11(513):eaaw5589. doi: 10.1126/scitranslmed.aaw5589. Sci Transl Med. 2019. PMID: 31597754 Free PMC article.
Assessing the impact of AGS-004, a dendritic cell-based immunotherapy, and vorinostat on persistent HIV-1 Infection.
Gay CL, Kuruc JD, Falcinelli SD, Warren JA, Reifeis SA, Kirchherr JL, James KS, Dewey MG, Helms A, Allard B, Stuelke E, Gamble A, Plachco A, Gorelick RJ, Eron JJ, Hudgens M, Garrido C, Goonetilleke N, DeBenedette MA, Tcherepanova IY, Nicolette CA, Archin NM, Margolis DM. Gay CL, et al. Among authors: goonetilleke n. Sci Rep. 2020 Mar 20;10(1):5134. doi: 10.1038/s41598-020-61878-3. Sci Rep. 2020. PMID: 32198428 Free PMC article.
The HIV-1 latent reservoir is largely sensitive to circulating T cells.
Warren JA, Zhou S, Xu Y, Moeser MJ, MacMillan DR, Council O, Kirchherr J, Sung JM, Roan NR, Adimora AA, Joseph S, Kuruc JD, Gay CL, Margolis DM, Archin N, Brumme ZL, Swanstrom R, Goonetilleke N. Warren JA, et al. Among authors: goonetilleke n. Elife. 2020 Oct 6;9:e57246. doi: 10.7554/eLife.57246. Elife. 2020. PMID: 33021198 Free PMC article.
Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency.
Archin NM, Kirchherr JL, Sung JA, Clutton G, Sholtis K, Xu Y, Allard B, Stuelke E, Kashuba AD, Kuruc JD, Eron J, Gay CL, Goonetilleke N, Margolis DM. Archin NM, et al. Among authors: goonetilleke n. J Clin Invest. 2017 Aug 1;127(8):3126-3135. doi: 10.1172/JCI92684. Epub 2017 Jul 17. J Clin Invest. 2017. PMID: 28714868 Free PMC article.
HIV-Specific, Ex Vivo Expanded T Cell Therapy: Feasibility, Safety, and Efficacy in ART-Suppressed HIV-Infected Individuals.
Sung JA, Patel S, Clohosey ML, Roesch L, Tripic T, Kuruc JD, Archin N, Hanley PJ, Cruz CR, Goonetilleke N, Eron JJ, Rooney CM, Gay CL, Bollard CM, Margolis DM. Sung JA, et al. Among authors: goonetilleke n. Mol Ther. 2018 Oct 3;26(10):2496-2506. doi: 10.1016/j.ymthe.2018.08.015. Epub 2018 Sep 21. Mol Ther. 2018. PMID: 30249388 Free PMC article. Clinical Trial.
HIV-Specific T Cell Responses Are Highly Stable on Antiretroviral Therapy.
Xu Y, Trumble IM, Warren JA, Clutton G, Abad-Fernandez M, Kirchnerr J, Adimora AA, Deeks SG, Margolis DM, Kuruc JD, Gay CL, Archin NM, Mollan KR, Hudgens M, Goonetilleke N. Xu Y, et al. Among authors: goonetilleke n. Mol Ther Methods Clin Dev. 2019 Aug 14;15:9-17. doi: 10.1016/j.omtm.2019.07.008. eCollection 2019 Dec 13. Mol Ther Methods Clin Dev. 2019. PMID: 31534983 Free PMC article.
85 results