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Antioxidant regulation of protein kinase C in cancer prevention.
Gopalakrishna R, Gundimeda U. Gopalakrishna R, et al. J Nutr. 2002 Dec;132(12):3819S-3823S. doi: 10.1093/jn/132.12.3819S. J Nutr. 2002. PMID: 12468631
Methods for studying oxidative regulation of protein kinase C.
Gopalakrishna R, McNeill TH, Elhiani AA, Gundimeda U. Gopalakrishna R, et al. Methods Enzymol. 2013;528:79-98. doi: 10.1016/B978-0-12-405881-1.00005-7. Methods Enzymol. 2013. PMID: 23849860
Green tea polyphenols precondition against cell death induced by oxygen-glucose deprivation via stimulation of laminin receptor, generation of reactive oxygen species, and activation of protein kinase Cε.
Gundimeda U, McNeill TH, Elhiani AA, Schiffman JE, Hinton DR, Gopalakrishna R. Gundimeda U, et al. Among authors: gopalakrishna r. J Biol Chem. 2012 Oct 5;287(41):34694-708. doi: 10.1074/jbc.M112.356899. Epub 2012 Aug 9. J Biol Chem. 2012. PMID: 22879598 Free PMC article.
In this study using an oxygen-glucose deprivation and reoxygenation (OGD/R) model in PC12 cells, we show that 2-day pretreatment with green tea polyphenols (GTPP) and their active ingredient, epigallocatechin-3-gallate (EGCG), protects cells from subsequent OGD/R-in …
In this study using an oxygen-glucose deprivation and reoxygenation (OGD/R) model in PC12 cells, we show that 2-day pretreatment with …
Negation of the cancer-preventive actions of selenium by over-expression of protein kinase Cepsilon and selenoprotein thioredoxin reductase.
Gundimeda U, Schiffman JE, Gottlieb SN, Roth BI, Gopalakrishna R. Gundimeda U, et al. Among authors: gopalakrishna r. Carcinogenesis. 2009 Sep;30(9):1553-61. doi: 10.1093/carcin/bgp164. Epub 2009 Jul 3. Carcinogenesis. 2009. PMID: 19578042
Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells.
Gundimeda U, Schiffman JE, Chhabra D, Wong J, Wu A, Gopalakrishna R. Gundimeda U, et al. Among authors: gopalakrishna r. J Biol Chem. 2008 Dec 12;283(50):34519-31. doi: 10.1074/jbc.M807007200. Epub 2008 Oct 15. J Biol Chem. 2008. PMID: 18922790 Free PMC article.
A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells.
Gopalakrishna R, Gundimeda U, Schiffman JE, McNeill TH. Gopalakrishna R, et al. J Biol Chem. 2008 May 23;283(21):14430-44. doi: 10.1074/jbc.M801519200. Epub 2008 Mar 28. J Biol Chem. 2008. PMID: 18375950 Free PMC article.
Estrogen activates protein kinase C in neurons: role in neuroprotection.
Cordey M, Gundimeda U, Gopalakrishna R, Pike CJ. Cordey M, et al. Among authors: gopalakrishna r. J Neurochem. 2003 Mar;84(6):1340-8. doi: 10.1046/j.1471-4159.2003.01631.x. J Neurochem. 2003. PMID: 12614334
Redox regulation of protein kinase C by selenometabolites and selenoprotein thioredoxin reductase limits cancer prevention by selenium.
Gopalakrishna R, Gundimeda U, Zhou S, Bui H, Holmgren A. Gopalakrishna R, et al. Free Radic Biol Med. 2018 Nov 1;127:55-61. doi: 10.1016/j.freeradbiomed.2018.05.062. Epub 2018 May 22. Free Radic Biol Med. 2018. PMID: 29775743 Review.
Imbalance in Protein Thiol Redox Regulation and Cancer-Preventive Efficacy of Selenium.
Gopalakrishna R, Gundimeda U, Zhou S, Zung K, Forell K, Holmgren A. Gopalakrishna R, et al. React Oxyg Species (Apex). 2016;2(4):272-289. doi: 10.20455/ros.2016.851. Epub 2016 May 25. React Oxyg Species (Apex). 2016. PMID: 29795790 Free PMC article.
Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis.
Gopalakrishna R, Barsky SH. Gopalakrishna R, et al. Proc Natl Acad Sci U S A. 1988 Jan;85(2):612-6. doi: 10.1073/pnas.85.2.612. Proc Natl Acad Sci U S A. 1988. PMID: 3422445 Free PMC article.
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