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The cell cycle genes cdc22+ and suc22+ of the fission yeast Schizosaccharomyces pombe encode the large and small subunits of ribonucleotide reductase.
Fernandez Sarabia MJ, McInerny C, Harris P, Gordon C, Fantes P. Fernandez Sarabia MJ, et al. Among authors: gordon c. Mol Gen Genet. 1993 Apr;238(1-2):241-51. doi: 10.1007/BF00279553. Mol Gen Genet. 1993. PMID: 8479429
Nedd8 processing enzymes in Schizosaccharomyces pombe.
O'Donoghue JE, Bech-Otschir D, Larsen IB, Wallace M, Hartmann-Petersen R, Gordon C. O'Donoghue JE, et al. Among authors: gordon c. BMC Biochem. 2013 Mar 15;14:8. doi: 10.1186/1471-2091-14-8. BMC Biochem. 2013. PMID: 23496905 Free PMC article.
Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH.
Rainger J, Bengani H, Campbell L, Anderson E, Sokhi K, Lam W, Riess A, Ansari M, Smithson S, Lees M, Mercer C, McKenzie K, Lengfeld T, Gener Querol B, Branney P, McKay S, Morrison H, Medina B, Robertson M, Kohlhase J, Gordon C, Kirk J, Wieczorek D, Fitzpatrick DR. Rainger J, et al. Among authors: gordon c. Hum Mol Genet. 2012 Sep 15;21(18):3969-83. doi: 10.1093/hmg/dds218. Epub 2012 Jun 12. Hum Mol Genet. 2012. PMID: 22692683
The essential functions of NEDD8 are mediated via distinct surface regions, and not by polyneddylation in Schizosaccharomyces pombe.
Girdwood D, Xirodimas DP, Gordon C. Girdwood D, et al. Among authors: gordon c. PLoS One. 2011;6(5):e20089. doi: 10.1371/journal.pone.0020089. Epub 2011 May 31. PLoS One. 2011. PMID: 21655279 Free PMC article.
Here, we have performed alanine scanning mutagenesis of all conserved surface residues and show that the majority of essential residues were located around the hydrophobic patch and the C-terminus. ...
Here, we have performed alanine scanning mutagenesis of all conserved surface residues and show that the majority of essential residues were …
Constitutively active Cullin-RING-Ligases fail to rescue loss of NEDD8 conjugation in Schizosaccharomyces pombe.
Girdwood D, Robertson M, Gordon C. Girdwood D, et al. Among authors: gordon c. FEBS Lett. 2012 May 21;586(10):1522-8. doi: 10.1016/j.febslet.2012.04.011. Epub 2012 Apr 21. FEBS Lett. 2012. PMID: 22673520
We show here that a functional Pcu1p mutant, deleted for its C-terminal autoinhibitory domain, which negates the requirement of neddylation for ligase activity, is unable to rescue the loss of neddylation. ...
We show here that a functional Pcu1p mutant, deleted for its C-terminal autoinhibitory domain, which negates the requirement of neddy …
Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing.
Marinova IN, Engelbrecht J, Ewald A, Langholm LL, Holmberg C, Kragelund BB, Gordon C, Nielsen O, Hartmann-Petersen R. Marinova IN, et al. Among authors: gordon c. PLoS One. 2015 Feb 6;10(2):e0117779. doi: 10.1371/journal.pone.0117779. eCollection 2015. PLoS One. 2015. PMID: 25658828 Free PMC article.
Dss1 is a 26S proteasome ubiquitin receptor.
Paraskevopoulos K, Kriegenburg F, Tatham MH, Rösner HI, Medina B, Larsen IB, Brandstrup R, Hardwick KG, Hay RT, Kragelund BB, Hartmann-Petersen R, Gordon C. Paraskevopoulos K, et al. Among authors: gordon c. Mol Cell. 2014 Nov 6;56(3):453-61. doi: 10.1016/j.molcel.2014.09.008. Epub 2014 Oct 9. Mol Cell. 2014. PMID: 25306921 Free PMC article.
The ubiquitin-associated (UBA) 1 domain of Schizosaccharomyces pombe Rhp23 is essential for the recognition of ubiquitin-proteasome system substrates both in vitro and in vivo.
Medina B, Paraskevopoulos K, Boehringer J, Sznajder A, Robertson M, Endicott J, Gordon C. Medina B, et al. Among authors: gordon c. J Biol Chem. 2012 Dec 7;287(50):42344-51. doi: 10.1074/jbc.M112.419838. Epub 2012 Oct 4. J Biol Chem. 2012. PMID: 23038266 Free PMC article.
Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission yeast.
Stone M, Hartmann-Petersen R, Seeger M, Bech-Otschir D, Wallace M, Gordon C. Stone M, et al. Among authors: gordon c. J Mol Biol. 2004 Nov 26;344(3):697-706. doi: 10.1016/j.jmb.2004.09.057. J Mol Biol. 2004. PMID: 15533439
Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain.
Trempe JF, Brown NR, Lowe ED, Gordon C, Campbell ID, Noble ME, Endicott JA. Trempe JF, et al. Among authors: gordon c. EMBO J. 2005 Sep 21;24(18):3178-89. doi: 10.1038/sj.emboj.7600797. Epub 2005 Sep 1. EMBO J. 2005. PMID: 16138082 Free PMC article.
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