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A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Jones RB, Gordus A, Krall JA, MacBeath G. Jones RB, et al. Among authors: gordus a. Nature. 2006 Jan 12;439(7073):168-74. doi: 10.1038/nature04177. Epub 2005 Nov 6. Nature. 2006. PMID: 16273093
Although epidermal growth factor receptor (EGFR; also called ErbB1) and its relatives initiate one of the most well-studied signalling networks, there is not yet a genome-wide view of even the earliest step in this pathway: recruitment of proteins to the activated receptor …
Although epidermal growth factor receptor (EGFR; also called ErbB1) and its relatives initiate one of the most well-studied signalling netwo …
Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.
Mehlitz A, Banhart S, Mäurer AP, Kaushansky A, Gordus AG, Zielecki J, Macbeath G, Meyer TF. Mehlitz A, et al. Among authors: gordus ag. J Cell Biol. 2010 Jul 12;190(1):143-57. doi: 10.1083/jcb.200909095. J Cell Biol. 2010. PMID: 20624904 Free PMC article.
Here, we used a protein microarray comprising virtually all human SRC homology 2 (SH2) and phosphotyrosine binding domains to comprehensively and quantitatively assess interactions between host cell proteins and the early phase Chlamydia trachomatis effector protein transl …
Here, we used a protein microarray comprising virtually all human SRC homology 2 (SH2) and phosphotyrosine binding domains to compreh …
Quantifying protein-protein interactions in high throughput using protein domain microarrays.
Kaushansky A, Allen JE, Gordus A, Stiffler MA, Karp ES, Chang BH, MacBeath G. Kaushansky A, et al. Among authors: gordus a. Nat Protoc. 2010 Apr;5(4):773-90. doi: 10.1038/nprot.2010.36. Epub 2010 Apr 1. Nat Protoc. 2010. PMID: 20360771 Free PMC article.
One drawback of this technique is that proteins show a broad range of physicochemical properties and are often difficult to produce recombinantly. ...Because entire domain families can be interrogated simultaneously, they provide a powerful way to assess binding sel …
One drawback of this technique is that proteins show a broad range of physicochemical properties and are often difficult to produce r …
Linear combinations of docking affinities explain quantitative differences in RTK signaling.
Gordus A, Krall JA, Beyer EM, Kaushansky A, Wolf-Yadlin A, Sevecka M, Chang BH, Rush J, MacBeath G. Gordus A, et al. Mol Syst Biol. 2009;5:235. doi: 10.1038/msb.2008.72. Epub 2009 Jan 20. Mol Syst Biol. 2009. PMID: 19156127 Free PMC article.
Receptor tyrosine kinases (RTKs) process extracellular cues by activating a broad array of signaling proteins. Paradoxically, they often use the same proteins to elicit diverse and even opposing phenotypic responses. ...
Receptor tyrosine kinases (RTKs) process extracellular cues by activating a broad array of signaling proteins. Paradoxically, they of …
Circumventing the problems caused by protein diversity in microarrays: implications for protein interaction networks.
Gordus A, MacBeath G. Gordus A, et al. J Am Chem Soc. 2006 Oct 25;128(42):13668-9. doi: 10.1021/ja065381g. J Am Chem Soc. 2006. PMID: 17044677
If a simple threshold-based approach is used to define protein-protein interactions, the resulting binary networks can be strongly biased. ...When a threshold-based binding assay is performed on these domains using fluorescently labeled phosphopeptides, a mis …
If a simple threshold-based approach is used to define protein-protein interactions, the resulting binary networks can be strongly bi …
Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected.
Koytiger G, Kaushansky A, Gordus A, Rush J, Sorger PK, MacBeath G. Koytiger G, et al. Among authors: gordus a. Mol Cell Proteomics. 2013 May;12(5):1204-13. doi: 10.1074/mcp.M112.025858. Epub 2013 Jan 28. Mol Cell Proteomics. 2013. PMID: 23358503 Free PMC article.
A quantitative study of the recruitment potential of all intracellular tyrosine residues on EGFR, FGFR1 and IGF1R.
Kaushansky A, Gordus A, Chang B, Rush J, MacBeath G. Kaushansky A, et al. Among authors: gordus a. Mol Biosyst. 2008 Jun;4(6):643-53. doi: 10.1039/b801018h. Epub 2008 Apr 8. Mol Biosyst. 2008. PMID: 18493663 Free PMC article.
System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties.
Kaushansky A, Gordus A, Budnik BA, Lane WS, Rush J, MacBeath G. Kaushansky A, et al. Among authors: gordus a. Chem Biol. 2008 Aug 25;15(8):808-17. doi: 10.1016/j.chembiol.2008.07.006. Chem Biol. 2008. PMID: 18721752 Free PMC article.
The first three members of the ErbB family of receptor tyrosine kinases activate a wide variety of signaling pathways and are frequently misregulated in cancer. ...At a systems level, we found that ErbB4 is much more selective than the other ErbB receptors. This sug …
The first three members of the ErbB family of receptor tyrosine kinases activate a wide variety of signaling pathways and are frequen …
Single-molecule transition-state analysis of RNA folding.
Bokinsky G, Rueda D, Misra VK, Rhodes MM, Gordus A, Babcock HP, Walter NG, Zhuang X. Bokinsky G, et al. Among authors: gordus a. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9302-7. doi: 10.1073/pnas.1133280100. Epub 2003 Jul 17. Proc Natl Acad Sci U S A. 2003. PMID: 12869691 Free PMC article.
A critical step toward solving the RNA folding problem is the characterization of the associated transition states. This is a challenging task in part because the rugged energy landscape of RNA often leads to the coexistence of multiple distinct structural transitio
A critical step toward solving the RNA folding problem is the characterization of the associated transition states. This is a
An optimized fluorescent probe for visualizing glutamate neurotransmission.
Marvin JS, Borghuis BG, Tian L, Cichon J, Harnett MT, Akerboom J, Gordus A, Renninger SL, Chen TW, Bargmann CI, Orger MB, Schreiter ER, Demb JB, Gan WB, Hires SA, Looger LL. Marvin JS, et al. Among authors: gordus a. Nat Methods. 2013 Feb;10(2):162-70. doi: 10.1038/nmeth.2333. Epub 2013 Jan 13. Nat Methods. 2013. PMID: 23314171 Free PMC article.
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