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Neuronal PTP1B regulates body weight, adiposity and leptin action.
Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Bence KK, et al. Nat Med. 2006 Aug;12(8):917-24. doi: 10.1038/nm1435. Epub 2006 Jul 16. Nat Med. 2006. PMID: 16845389
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Görgün C, Glimcher LH, Hotamisligil GS. Ozcan U, et al. Science. 2004 Oct 15;306(5695):457-61. doi: 10.1126/science.1103160. Science. 2004. PMID: 15486293
Role of peroxisome proliferator-activated receptor {delta}/{beta} in hepatic metabolic regulation.
Liu S, Hatano B, Zhao M, Yen CC, Kang K, Reilly SM, Gangl MR, Gorgun C, Balschi JA, Ntambi JM, Lee CH. Liu S, et al. J Biol Chem. 2011 Jan 14;286(2):1237-47. doi: 10.1074/jbc.M110.138115. Epub 2010 Nov 8. J Biol Chem. 2011. PMID: 21059653 Free PMC article.
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice.
Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP. Liu J, et al. Among authors: gorgun cz. Nat Med. 2009 Aug;15(8):940-5. doi: 10.1038/nm.1994. Epub 2009 Jul 26. Nat Med. 2009. PMID: 19633655 Free PMC article.
Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice.
Furuhashi M, Fucho R, Görgün CZ, Tuncman G, Cao H, Hotamisligil GS. Furuhashi M, et al. Among authors: gorgun cz. J Clin Invest. 2008 Jul;118(7):2640-50. doi: 10.1172/JCI34750. J Clin Invest. 2008. PMID: 18551191 Free PMC article.
Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.
Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS. Furuhashi M, et al. Among authors: gorgun cz. Nature. 2007 Jun 21;447(7147):959-65. doi: 10.1038/nature05844. Epub 2007 Jun 6. Nature. 2007. PMID: 17554340 Free PMC article.
Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis.
Wellen KE, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F, Hotamisligil GS. Wellen KE, et al. Among authors: gorgun cz. Cell. 2007 May 4;129(3):537-48. doi: 10.1016/j.cell.2007.02.049. Cell. 2007. PMID: 17482547 Free PMC article.
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.
Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Görgün CZ, Hotamisligil GS. Ozcan U, et al. Science. 2006 Aug 25;313(5790):1137-40. doi: 10.1126/science.1128294. Science. 2006. PMID: 16931765 Free PMC article.
Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.
Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS. Maeda K, et al. Cell Metab. 2005 Feb;1(2):107-19. doi: 10.1016/j.cmet.2004.12.008. Cell Metab. 2005. PMID: 16054052
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