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Bacterial killing by complement requires membrane attack complex formation via surface-bound C5 convertases.
Heesterbeek DA, Bardoel BW, Parsons ES, Bennett I, Ruyken M, Doorduijn DJ, Gorham RD Jr, Berends ET, Pyne AL, Hoogenboom BW, Rooijakkers SH. Heesterbeek DA, et al. Among authors: gorham rd jr. EMBO J. 2019 Feb 15;38(4):e99852. doi: 10.15252/embj.201899852. Epub 2019 Jan 14. EMBO J. 2019. PMID: 30643019 Free PMC article.
Virtual Screening of Chemical Compounds for Discovery of Complement C3 Ligands.
Mohan RR, Wilson M, Gorham RD Jr, Harrison RES, Morikis VA, Kieslich CA, Orr AA, Coley AV, Tamamis P, Morikis D. Mohan RR, et al. Among authors: gorham rd jr. ACS Omega. 2018 Jun 30;3(6):6427-6438. doi: 10.1021/acsomega.8b00606. Epub 2018 Jun 15. ACS Omega. 2018. PMID: 30221234 Free PMC article.
Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models.
Zwarthoff SA, Berends ETM, Mol S, Ruyken M, Aerts PC, Józsi M, de Haas CJC, Rooijakkers SHM, Gorham RD Jr. Zwarthoff SA, et al. Among authors: gorham rd jr. Front Immunol. 2018 Jul 23;9:1691. doi: 10.3389/fimmu.2018.01691. eCollection 2018. Front Immunol. 2018. PMID: 30083158 Free PMC article.
The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins.
Praest P, Luteijn RD, Brak-Boer IGJ, Lanfermeijer J, Hoelen H, Ijgosse L, Costa AI, Gorham RD Jr, Lebbink RJ, Wiertz EJHJ. Praest P, et al. Among authors: gorham rd jr. Mol Immunol. 2018 Sep;101:55-64. doi: 10.1016/j.molimm.2018.05.025. Epub 2018 Jun 4. Mol Immunol. 2018. PMID: 29879547 Free article.
AESOP: A Python Library for Investigating Electrostatics in Protein Interactions.
Harrison RES, Mohan RR, Gorham RD Jr, Kieslich CA, Morikis D. Harrison RES, et al. Among authors: gorham rd jr. Biophys J. 2017 May 9;112(9):1761-1766. doi: 10.1016/j.bpj.2017.04.005. Biophys J. 2017. PMID: 28494947 Free PMC article.
Let's Tie the Knot: Marriage of Complement and Adaptive Immunity in Pathogen Evasion, for Better or Worse.
Bennett KM, Rooijakkers SH, Gorham RD Jr. Bennett KM, et al. Among authors: gorham rd jr. Front Microbiol. 2017 Jan 31;8:89. doi: 10.3389/fmicb.2017.00089. eCollection 2017. Front Microbiol. 2017. PMID: 28197139 Free PMC article. Review.
Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration.
Mohan RR, Cabrera AP, Harrison RE, Gorham RD Jr, Johnson LV, Ghosh K, Morikis D. Mohan RR, et al. Among authors: gorham rd jr. Mol Vis. 2016 Oct 26;22:1280-1290. eCollection 2016. Mol Vis. 2016. PMID: 27829783 Free PMC article.
Quantitative Modeling of the Alternative Pathway of the Complement System.
Zewde N, Gorham RD Jr, Dorado A, Morikis D. Zewde N, et al. Among authors: gorham rd jr. PLoS One. 2016 Mar 31;11(3):e0152337. doi: 10.1371/journal.pone.0152337. eCollection 2016. PLoS One. 2016. PMID: 27031863 Free PMC article.
Staphylococcal Immune Evasion Proteins: Structure, Function, and Host Adaptation.
Koymans KJ, Vrieling M, Gorham RD Jr, van Strijp JAG. Koymans KJ, et al. Among authors: gorham rd jr. Curr Top Microbiol Immunol. 2017;409:441-489. doi: 10.1007/82_2015_5017. Curr Top Microbiol Immunol. 2017. PMID: 26919864 Review.
Discovery of Small Molecules for Fluorescent Detection of Complement Activation Product C3d.
Gorham RD Jr, Nuñez V, Lin JH, Rooijakkers SH, Vullev VI, Morikis D. Gorham RD Jr, et al. J Med Chem. 2015 Dec 24;58(24):9535-45. doi: 10.1021/acs.jmedchem.5b01062. Epub 2015 Dec 9. J Med Chem. 2015. PMID: 26613117 Free article.
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