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Walking over the inflammasome.
Gorka O, Neuwirt E, Groß O. Gorka O, et al. Nat Chem Biol. 2019 Jun;15(6):552-553. doi: 10.1038/s41589-019-0292-8. Nat Chem Biol. 2019. PMID: 31086328 No abstract available.
The Nlrp3 inflammasome regulates acute graft-versus-host disease.
Jankovic D, Ganesan J, Bscheider M, Stickel N, Weber FC, Guarda G, Follo M, Pfeifer D, Tardivel A, Ludigs K, Bouazzaoui A, Kerl K, Fischer JC, Haas T, Schmitt-Gräff A, Manoharan A, Müller L, Finke J, Martin SF, Gorka O, Peschel C, Ruland J, Idzko M, Duyster J, Holler E, French LE, Poeck H, Contassot E, Zeiser R. Jankovic D, et al. Among authors: gorka o. J Exp Med. 2013 Sep 23;210(10):1899-910. doi: 10.1084/jem.20130084. Epub 2013 Aug 26. J Exp Med. 2013. PMID: 23980097 Free PMC article.
K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria.
Groß CJ, Mishra R, Schneider KS, Médard G, Wettmarshausen J, Dittlein DC, Shi H, Gorka O, Koenig PA, Fromm S, Magnani G, Ćiković T, Hartjes L, Smollich J, Robertson AAB, Cooper MA, Schmidt-Supprian M, Schuster M, Schroder K, Broz P, Traidl-Hoffmann C, Beutler B, Kuster B, Ruland J, Schneider S, Perocchi F, Groß O. Groß CJ, et al. Among authors: gorka o. Immunity. 2016 Oct 18;45(4):761-773. doi: 10.1016/j.immuni.2016.08.010. Epub 2016 Sep 27. Immunity. 2016. PMID: 27692612 Free article.
The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity.
Schneider KS, Groß CJ, Dreier RF, Saller BS, Mishra R, Gorka O, Heilig R, Meunier E, Dick MS, Ćiković T, Sodenkamp J, Médard G, Naumann R, Ruland J, Kuster B, Broz P, Groß O. Schneider KS, et al. Among authors: gorka o. Cell Rep. 2017 Dec 26;21(13):3846-3859. doi: 10.1016/j.celrep.2017.12.018. Cell Rep. 2017. PMID: 29281832 Free PMC article.
Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade.
Roth S, Cao J, Singh V, Tiedt S, Hundeshagen G, Li T, Boehme JD, Chauhan D, Zhu J, Ricci A, Gorka O, Asare Y, Yang J, Lopez MS, Rehberg M, Bruder D, Zhang S, Groß O, Dichgans M, Hornung V, Liesz A. Roth S, et al. Among authors: gorka o. Immunity. 2021 Apr 13;54(4):648-659.e8. doi: 10.1016/j.immuni.2021.02.004. Epub 2021 Mar 4. Immunity. 2021. PMID: 33667383 Free article.
NLRP3 as a sensor of metabolism gone awry.
Neuwirt E, Gorka O, Saller BS, Groß CJ, Madl T, Groß O. Neuwirt E, et al. Among authors: gorka o. Curr Opin Biotechnol. 2021 Apr;68:300-309. doi: 10.1016/j.copbio.2021.03.009. Epub 2021 Apr 13. Curr Opin Biotechnol. 2021. PMID: 33862489 Review.
22 results