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Modulation of oxidative stress as an anticancer strategy.
Gorrini C, Harris IS, Mak TW. Gorrini C, et al. Nat Rev Drug Discov. 2013 Dec;12(12):931-47. doi: 10.1038/nrd4002. Nat Rev Drug Discov. 2013. PMID: 24287781 Review.
Glutathione Primes T Cell Metabolism for Inflammation.
Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D. Mak TW, et al. Among authors: gorrini c. Immunity. 2017 Apr 18;46(4):675-689. doi: 10.1016/j.immuni.2017.03.019. Immunity. 2017. PMID: 28423341 Free article.
The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair.
Bassi C, Li YT, Khu K, Mateo F, Baniasadi PS, Elia A, Mason J, Stambolic V, Pujana MA, Mak TW, Gorrini C. Bassi C, et al. Among authors: gorrini c. Cell Death Differ. 2016 Jul;23(7):1198-208. doi: 10.1038/cdd.2015.173. Epub 2016 Feb 26. Cell Death Differ. 2016. PMID: 26915295 Free PMC article.
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress.
Bassi C, Ho J, Srikumar T, Dowling RJ, Gorrini C, Miller SJ, Mak TW, Neel BG, Raught B, Stambolic V. Bassi C, et al. Among authors: gorrini c. Science. 2013 Jul 26;341(6144):395-9. doi: 10.1126/science.1236188. Science. 2013. PMID: 23888040 Free PMC article.
PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling.
Harris IS, Blaser H, Moreno J, Treloar AE, Gorrini C, Sasaki M, Mason JM, Knobbe CB, Rufini A, Hallé M, Elia AJ, Wakeham A, Tremblay ML, Melino G, Done S, Mak TW. Harris IS, et al. Among authors: gorrini c. Oncogene. 2014 Feb 20;33(8):1047-54. doi: 10.1038/onc.2013.24. Epub 2013 Feb 25. Oncogene. 2014. PMID: 23435421
Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells.
Cappello P, Blaser H, Gorrini C, Lin DC, Elia AJ, Wakeham A, Haider S, Boutros PC, Mason JM, Miller NA, Youngson B, Done SJ, Mak TW. Cappello P, et al. Among authors: gorrini c. Oncogene. 2014 May 1;33(18):2375-84. doi: 10.1038/onc.2013.183. Epub 2013 May 27. Oncogene. 2014. PMID: 23708664
Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway.
Gorrini C, Gang BP, Bassi C, Wakeham A, Baniasadi SP, Hao Z, Li WY, Cescon DW, Li YT, Molyneux S, Penrod N, Lupien M, Schmidt EE, Stambolic V, Gauthier ML, Mak TW. Gorrini C, et al. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4472-7. doi: 10.1073/pnas.1324136111. Epub 2014 Feb 24. Proc Natl Acad Sci U S A. 2014. PMID: 24567396 Free PMC article.
Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.
Harris IS, Treloar AE, Inoue S, Sasaki M, Gorrini C, Lee KC, Yung KY, Brenner D, Knobbe-Thomsen CB, Cox MA, Elia A, Berger T, Cescon DW, Adeoye A, Brüstle A, Molyneux SD, Mason JM, Li WY, Yamamoto K, Wakeham A, Berman HK, Khokha R, Done SJ, Kavanagh TJ, Lam CW, Mak TW. Harris IS, et al. Among authors: gorrini c. Cancer Cell. 2015 Feb 9;27(2):211-22. doi: 10.1016/j.ccell.2014.11.019. Epub 2015 Jan 22. Cancer Cell. 2015. PMID: 25620030
Breaking up is hard to do: PI3K isoforms on the rebound.
Cescon DW, Gorrini C, Mak TW. Cescon DW, et al. Among authors: gorrini c. Cancer Cell. 2015 Jan 12;27(1):5-7. doi: 10.1016/j.ccell.2014.12.003. Cancer Cell. 2015. PMID: 25584888
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.
Inoue S, Hao Z, Elia AJ, Cescon D, Zhou L, Silvester J, Snow B, Harris IS, Sasaki M, Li WY, Itsumi M, Yamamoto K, Ueda T, Dominguez-Brauer C, Gorrini C, Chio II, Haight J, You-Ten A, McCracken S, Wakeham A, Ghazarian D, Penn LJ, Melino G, Mak TW. Inoue S, et al. Among authors: gorrini c. Genes Dev. 2013 May 15;27(10):1101-14. doi: 10.1101/gad.214577.113. Genes Dev. 2013. PMID: 23699408 Free PMC article.
Notably, in the absence of Mule, c-Myc/Miz1 transcriptional complexes accumulated, and levels of p21CDKN1A (p21) and p15INK4B (p15) were down-regulated. ...Our data demonstrate in vivo that Mule suppresses Ras-mediated tumorigenesis by preventing an accumulation of c
Notably, in the absence of Mule, c-Myc/Miz1 transcriptional complexes accumulated, and levels of p21CDKN1A (p21) and p15INK4B (p15) w …
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