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Targeting multidrug resistance in cancer.
Szakács G, Paterson JK, Ludwig JA, Booth-Genthe C, Gottesman MM. Szakács G, et al. Among authors: gottesman mm. Nat Rev Drug Discov. 2006 Mar;5(3):219-34. doi: 10.1038/nrd1984. Nat Rev Drug Discov. 2006. PMID: 16518375 Review.
Transfer and expression of the human multidrug resistance gene in mouse erythroleukemia cells.
DelaFlor-Weiss E, Richardson C, Ward M, Himelstein A, Smith L, Podda S, Gottesman M, Pastan I, Bank A. DelaFlor-Weiss E, et al. Among authors: gottesman m. Blood. 1992 Dec 15;80(12):3106-11. Blood. 1992. PMID: 1281691
Multidrug resistance in human cancer.
Goldstein LJ, Pastan I, Gottesman MM. Goldstein LJ, et al. Among authors: gottesman mm. Crit Rev Oncol Hematol. 1992;12(3):243-53. doi: 10.1016/1040-8428(92)90057-w. Crit Rev Oncol Hematol. 1992. PMID: 1353966 Review. No abstract available.
Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.
Ambudkar SV, Lelong IH, Zhang J, Cardarelli CO, Gottesman MM, Pastan I. Ambudkar SV, et al. Among authors: gottesman mm. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8472-6. doi: 10.1073/pnas.89.18.8472. Proc Natl Acad Sci U S A. 1992. PMID: 1356264 Free PMC article.
Is the multidrug transporter a flippase?
Higgins CF, Gottesman MM. Higgins CF, et al. Among authors: gottesman mm. Trends Biochem Sci. 1992 Jan;17(1):18-21. doi: 10.1016/0968-0004(92)90419-a. Trends Biochem Sci. 1992. PMID: 1374941 Review.
Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance.
Mickisch GH, Merlino GT, Galski H, Gottesman MM, Pastan I. Mickisch GH, et al. Among authors: gottesman mm. Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):547-51. doi: 10.1073/pnas.88.2.547. Proc Natl Acad Sci U S A. 1991. PMID: 1671173 Free PMC article.
Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles.
Horio M, Lovelace E, Pastan I, Gottesman MM. Horio M, et al. Among authors: gottesman mm. Biochim Biophys Acta. 1991 Jan 9;1061(1):106-10. doi: 10.1016/0005-2736(91)90274-c. Biochim Biophys Acta. 1991. PMID: 1671642
., Gottesman, M.M. and Pastan, I. (1988) Proc. Natl. Acad. Sci. USA 85, 3580-3584). Certain calcium-channel blockers, quinidine, and phenothiazines are able to overcome multidrug resistance in cultured cells. ...
., Gottesman, M.M. and Pastan, I. (1988) Proc. Natl. Acad. Sci. USA 85, 3580-3584). Certain calcium-channel blockers, quinidine, and …
Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression.
Shen DW, Lu YG, Chin KV, Pastan I, Gottesman MM. Shen DW, et al. Among authors: gottesman mm. J Cell Sci. 1991 Mar;98 ( Pt 3):317-22. J Cell Sci. 1991. PMID: 1676033
New potent verapamil derivatives that reverse multidrug resistance in human renal carcinoma cells and in transgenic mice expressing the human MDR1 gene.
Mickisch GH, Merlino GT, Aiken PM, Gottesman MM, Pastan I. Mickisch GH, et al. Among authors: gottesman mm. J Urol. 1991 Aug;146(2):447-53. doi: 10.1016/s0022-5347(17)37822-9. J Urol. 1991. PMID: 1677434
Chemotherapy and chemosensitization of transgenic mice which express the human multidrug resistance gene in bone marrow: efficacy, potency, and toxicity.
Mickisch GH, Licht T, Merlino GT, Gottesman MM, Pastan I. Mickisch GH, et al. Among authors: gottesman mm. Cancer Res. 1991 Oct 1;51(19):5417-24. Cancer Res. 1991. PMID: 1680550
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