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Cancer cells induce interleukin-22 production from memory CD4+ T cells via interleukin-1 to promote tumor growth.
Voigt C, May P, Gottschlich A, Markota A, Wenk D, Gerlach I, Voigt S, Stathopoulos GT, Arendt KAM, Heise C, Rataj F, Janssen KP, Königshoff M, Winter H, Himsl I, Thasler WE, Schnurr M, Rothenfußer S, Endres S, Kobold S. Voigt C, et al. Among authors: gottschlich a. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12994-12999. doi: 10.1073/pnas.1705165114. Epub 2017 Nov 17. Proc Natl Acad Sci U S A. 2017. PMID: 29150554 Free PMC article.
Can we use interleukin-1β blockade for lung cancer treatment?
Gottschlich A, Endres S, Kobold S. Gottschlich A, et al. Transl Lung Cancer Res. 2018 Apr;7(Suppl 2):S160-S164. doi: 10.21037/tlcr.2018.03.15. Transl Lung Cancer Res. 2018. PMID: 29780710 Free PMC article. No abstract available.
Interleukin-37 monomer is the active form for reducing innate immunity.
Eisenmesser EZ, Gottschlich A, Redzic JS, Paukovich N, Nix JC, Azam T, Zhang L, Zhao R, Kieft JS, The E, Meng X, Dinarello CA. Eisenmesser EZ, et al. Among authors: gottschlich a. Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5514-5522. doi: 10.1073/pnas.1819672116. Epub 2019 Feb 28. Proc Natl Acad Sci U S A. 2019. PMID: 30819901 Free PMC article.
A modular and controllable T cell therapy platform for acute myeloid leukemia.
Benmebarek MR, Cadilha BL, Herrmann M, Lesch S, Schmitt S, Stoiber S, Darwich A, Augsberger C, Brauchle B, Rohrbacher L, Oner A, Seifert M, Schwerdtfeger M, Gottschlich A, Rataj F, Fenn NC, Klein C, Subklewe M, Endres S, Hopfner KP, Kobold S. Benmebarek MR, et al. Among authors: gottschlich a. Leukemia. 2021 Aug;35(8):2243-2257. doi: 10.1038/s41375-020-01109-w. Epub 2021 Jan 7. Leukemia. 2021. PMID: 33414484 Free PMC article.
Therapeutic Strategies for Targeting IL-1 in Cancer.
Gottschlich A, Endres S, Kobold S. Gottschlich A, et al. Cancers (Basel). 2021 Jan 26;13(3):477. doi: 10.3390/cancers13030477. Cancers (Basel). 2021. PMID: 33530653 Free PMC article. Review.
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.
Lesch S, Blumenberg V, Stoiber S, Gottschlich A, Ogonek J, Cadilha BL, Dantes Z, Rataj F, Dorman K, Lutz J, Karches CH, Heise C, Kurzay M, Larimer BM, Grassmann S, Rapp M, Nottebrock A, Kruger S, Tokarew N, Metzger P, Hoerth C, Benmebarek MR, Dhoqina D, Grünmeier R, Seifert M, Oener A, Umut Ö, Joaquina S, Vimeux L, Tran T, Hank T, Baba T, Huynh D, Megens RTA, Janssen KP, Jastroch M, Lamp D, Ruehland S, Di Pilato M, Pruessmann JN, Thomas M, Marr C, Ormanns S, Reischer A, Hristov M, Tartour E, Donnadieu E, Rothenfusser S, Duewell P, König LM, Schnurr M, Subklewe M, Liss AS, Halama N, Reichert M, Mempel TR, Endres S, Kobold S. Lesch S, et al. Among authors: gottschlich a. Nat Biomed Eng. 2021 Nov;5(11):1246-1260. doi: 10.1038/s41551-021-00737-6. Epub 2021 Jun 3. Nat Biomed Eng. 2021. PMID: 34083764 Free PMC article.
Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors.
Cadilha BL, Benmebarek MR, Dorman K, Oner A, Lorenzini T, Obeck H, Vänttinen M, Di Pilato M, Pruessmann JN, Stoiber S, Huynh D, Märkl F, Seifert M, Manske K, Suarez-Gosalvez J, Zeng Y, Lesch S, Karches CH, Heise C, Gottschlich A, Thomas M, Marr C, Zhang J, Pandey D, Feuchtinger T, Subklewe M, Mempel TR, Endres S, Kobold S. Cadilha BL, et al. Among authors: gottschlich a. Sci Adv. 2021 Jun 9;7(24):eabi5781. doi: 10.1126/sciadv.abi5781. Print 2021 Jun. Sci Adv. 2021. PMID: 34108220 Free PMC article.
CAR T cell therapy in solid tumors: a short review.
Umut Ö, Gottschlich A, Endres S, Kobold S. Umut Ö, et al. Among authors: gottschlich a. Memo. 2021;14(2):143-149. doi: 10.1007/s12254-021-00703-7. Epub 2021 Apr 8. Memo. 2021. PMID: 34777609 Free PMC article. Review.
The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors.
Kolorz J, Demir S, Gottschlich A, Beirith I, Ilmer M, Lüthy D, Walz C, Dorostkar MM, Magg T, Hauck F, von Schweinitz D, Kobold S, Kappler R, Berger M. Kolorz J, et al. Among authors: gottschlich a. Curr Oncol. 2021 Dec 26;29(1):94-110. doi: 10.3390/curroncol29010008. Curr Oncol. 2021. PMID: 35049682 Free PMC article.
Impact of the selective A2AR and A2BR dual antagonist AB928/etrumadenant on CAR T cell function.
Seifert M, Benmebarek MR, Briukhovetska D, Märkl F, Dörr J, Cadilha BL, Jobst J, Stock S, Andreu-Sanz D, Lorenzini T, Grünmeier R, Oner A, Obeck H, Majed L, Dhoqina D, Feinendegen M, Gottschlich A, Zhang J, Schindler U, Endres S, Kobold S. Seifert M, et al. Among authors: gottschlich a. Br J Cancer. 2022 Dec;127(12):2175-2185. doi: 10.1038/s41416-022-02013-z. Epub 2022 Oct 20. Br J Cancer. 2022. PMID: 36266575 Free PMC article.
51 results