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A highly conserved neutralizing epitope on group 2 influenza A viruses.
Ekiert DC, Friesen RH, Bhabha G, Kwaks T, Jongeneelen M, Yu W, Ophorst C, Cox F, Korse HJ, Brandenburg B, Vogels R, Brakenhoff JP, Kompier R, Koldijk MH, Cornelissen LA, Poon LL, Peiris M, Koudstaal W, Wilson IA, Goudsmit J. Ekiert DC, et al. Among authors: goudsmit j. Science. 2011 Aug 12;333(6044):843-50. doi: 10.1126/science.1204839. Epub 2011 Jul 7. Science. 2011. PMID: 21737702 Free PMC article.
Antibody recognition of a highly conserved influenza virus epitope.
Ekiert DC, Bhabha G, Elsliger MA, Friesen RH, Jongeneelen M, Throsby M, Goudsmit J, Wilson IA. Ekiert DC, et al. Among authors: goudsmit j. Science. 2009 Apr 10;324(5924):246-51. doi: 10.1126/science.1171491. Epub 2009 Feb 26. Science. 2009. PMID: 19251591 Free PMC article.
Highly conserved protective epitopes on influenza B viruses.
Dreyfus C, Laursen NS, Kwaks T, Zuijdgeest D, Khayat R, Ekiert DC, Lee JH, Metlagel Z, Bujny MV, Jongeneelen M, van der Vlugt R, Lamrani M, Korse HJ, Geelen E, Sahin Ö, Sieuwerts M, Brakenhoff JP, Vogels R, Li OT, Poon LL, Peiris M, Koudstaal W, Ward AB, Wilson IA, Goudsmit J, Friesen RH. Dreyfus C, et al. Among authors: goudsmit j. Science. 2012 Sep 14;337(6100):1343-8. doi: 10.1126/science.1222908. Epub 2012 Aug 9. Science. 2012. PMID: 22878502 Free PMC article.
A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen.
Impagliazzo A, Milder F, Kuipers H, Wagner MV, Zhu X, Hoffman RM, van Meersbergen R, Huizingh J, Wanningen P, Verspuij J, de Man M, Ding Z, Apetri A, Kükrer B, Sneekes-Vriese E, Tomkiewicz D, Laursen NS, Lee PS, Zakrzewska A, Dekking L, Tolboom J, Tettero L, van Meerten S, Yu W, Koudstaal W, Goudsmit J, Ward AB, Meijberg W, Wilson IA, Radošević K. Impagliazzo A, et al. Among authors: goudsmit j. Science. 2015 Sep 18;349(6254):1301-6. doi: 10.1126/science.aac7263. Epub 2015 Aug 24. Science. 2015. PMID: 26303961
Potent peptidic fusion inhibitors of influenza virus.
Kadam RU, Juraszek J, Brandenburg B, Buyck C, Schepens WBG, Kesteleyn B, Stoops B, Vreeken RJ, Vermond J, Goutier W, Tang C, Vogels R, Friesen RHE, Goudsmit J, van Dongen MJP, Wilson IA. Kadam RU, et al. Among authors: goudsmit j. Science. 2017 Oct 27;358(6362):496-502. doi: 10.1126/science.aan0516. Epub 2017 Sep 28. Science. 2017. PMID: 28971971 Free PMC article.
A small-molecule fusion inhibitor of influenza virus is orally active in mice.
van Dongen MJP, Kadam RU, Juraszek J, Lawson E, Brandenburg B, Schmitz F, Schepens WBG, Stoops B, van Diepen HA, Jongeneelen M, Tang C, Vermond J, van Eijgen-Obregoso Real A, Blokland S, Garg D, Yu W, Goutier W, Lanckacker E, Klap JM, Peeters DCG, Wu J, Buyck C, Jonckers THM, Roymans D, Roevens P, Vogels R, Koudstaal W, Friesen RHE, Raboisson P, Dhanak D, Goudsmit J, Wilson IA. van Dongen MJP, et al. Among authors: goudsmit j. Science. 2019 Mar 8;363(6431):eaar6221. doi: 10.1126/science.aar6221. Science. 2019. PMID: 30846569 Free PMC article.
A common solution to group 2 influenza virus neutralization.
Friesen RH, Lee PS, Stoop EJ, Hoffman RM, Ekiert DC, Bhabha G, Yu W, Juraszek J, Koudstaal W, Jongeneelen M, Korse HJ, Ophorst C, Brinkman-van der Linden EC, Throsby M, Kwakkenbos MJ, Bakker AQ, Beaumont T, Spits H, Kwaks T, Vogels R, Ward AB, Goudsmit J, Wilson IA. Friesen RH, et al. Among authors: goudsmit j. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):445-50. doi: 10.1073/pnas.1319058110. Epub 2013 Dec 11. Proc Natl Acad Sci U S A. 2014. PMID: 24335589 Free PMC article.
Mechanisms of hemagglutinin targeted influenza virus neutralization.
Brandenburg B, Koudstaal W, Goudsmit J, Klaren V, Tang C, Bujny MV, Korse HJ, Kwaks T, Otterstrom JJ, Juraszek J, van Oijen AM, Vogels R, Friesen RH. Brandenburg B, et al. Among authors: goudsmit j. PLoS One. 2013 Dec 11;8(12):e80034. doi: 10.1371/journal.pone.0080034. eCollection 2013. PLoS One. 2013. PMID: 24348996 Free PMC article.
582 results