Gourlay R - Search Results

1

Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1.

Zhang N, Gordon SL, Fritsch MJ, Esoof N, Campbell DG, Gourlay R, Velupillai S, Macartney T, Peggie M, van Aalten DM, Cousin MA, Alessi DR. Zhang N, et al. Among authors: gourlay r. J Neurosci. 2015 Feb 11;35(6):2492-507. doi: 10.1523/JNEUROSCI.4248-14.2015. J Neurosci. 2015. PMID: 25673844 Free PMC article.

2

Identification of Protor as a novel Rictor-binding component of mTOR complex-2.

Pearce LR, Huang X, Boudeau J, Pawłowski R, Wullschleger S, Deak M, Ibrahim AF, Gourlay R, Magnuson MA, Alessi DR. Pearce LR, et al. Among authors: gourlay r. Biochem J. 2007 Aug 1;405(3):513-22. doi: 10.1042/BJ20070540. Biochem J. 2007. PMID: 17461779 Free PMC article.

3

Novel procedure to investigate the effect of phosphorylation on protein complex formation in vitro and in cells.

Rembutsu M, Soutar MP, Van Aalten L, Gourlay R, Hastie CJ, McLauchlan H, Morrice NA, Cole AR, Sutherland C. Rembutsu M, et al. Among authors: gourlay r. Biochemistry. 2008 Feb 19;47(7):2153-61. doi: 10.1021/bi702030w. Epub 2008 Jan 26. Biochemistry. 2008. PMID: 18220421

4

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.

Filippi BM, de los Heros P, Mehellou Y, Navratilova I, Gourlay R, Deak M, Plater L, Toth R, Zeqiraj E, Alessi DR. Filippi BM, et al. Among authors: gourlay r. EMBO J. 2011 May 4;30(9):1730-41. doi: 10.1038/emboj.2011.78. Epub 2011 Mar 18. EMBO J. 2011. PMID: 21423148 Free PMC article.

5

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.

Kondapalli C, Kazlauskaite A, Zhang N, Woodroof HI, Campbell DG, Gourlay R, Burchell L, Walden H, Macartney TJ, Deak M, Knebel A, Alessi DR, Muqit MM. Kondapalli C, et al. Among authors: gourlay r. Open Biol. 2012 May;2(5):120080. doi: 10.1098/rsob.120080. Open Biol. 2012. PMID: 22724072 Free PMC article.

6

Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity.

Houde VP, Ritorto MS, Gourlay R, Varghese J, Davies P, Shpiro N, Sakamoto K, Alessi DR. Houde VP, et al. Among authors: gourlay r. Biochem J. 2014 Feb 15;458(1):41-56. doi: 10.1042/BJ20131324. Biochem J. 2014. PMID: 24295069 Free PMC article.

7

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.

de Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J. de Los Heros P, et al. Among authors: gourlay r. Biochem J. 2014 Mar 15;458(3):559-73. doi: 10.1042/BJ20131478. Biochem J. 2014. PMID: 24393035 Free PMC article.

8

Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling.

Vogt J, Dingwell KS, Herhaus L, Gourlay R, Macartney T, Campbell D, Smith JC, Sapkota GP. Vogt J, et al. Among authors: gourlay r. Open Biol. 2014 Feb 19;4(2):130210. doi: 10.1098/rsob.130210. Open Biol. 2014. PMID: 24554596 Free PMC article.

9

Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction.

van der Wijst J, Blanchard MG, Woodroof HI, Macartney TJ, Gourlay R, Hoenderop JG, Bindels RJ, Alessi DR. van der Wijst J, et al. Among authors: gourlay r. Biochem J. 2014 Jun 1;460(2):165-75. doi: 10.1042/BJ20131639. Biochem J. 2014. PMID: 24650431 Free PMC article.

10

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.

Kazlauskaite A, Kondapalli C, Gourlay R, Campbell DG, Ritorto MS, Hofmann K, Alessi DR, Knebel A, Trost M, Muqit MM. Kazlauskaite A, et al. Among authors: gourlay r. Biochem J. 2014 May 15;460(1):127-39. doi: 10.1042/BJ20140334. Biochem J. 2014. PMID: 24660806 Free PMC article.

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