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Small-molecule inhibitors of Bcl-2 family proteins as therapeutic agents in cancer.
Mohammad R, Giri A, Goustin AS. Mohammad R, et al. Among authors: goustin as. Recent Pat Anticancer Drug Discov. 2008 Jan;3(1):20-30. doi: 10.2174/157489208783478676. Recent Pat Anticancer Drug Discov. 2008. PMID: 18289121 Review.
Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of Bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1.
Mohammad RM, Goustin AS, Aboukameel A, Chen B, Banerjee S, Wang G, Nikolovska-Coleska Z, Wang S, Al-Katib A. Mohammad RM, et al. Among authors: goustin as. Clin Cancer Res. 2007 Apr 1;13(7):2226-35. doi: 10.1158/1078-0432.CCR-06-1574. Clin Cancer Res. 2007. PMID: 17404107 Free article.
SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status.
Al-Katib AM, Sun Y, Goustin AS, Azmi AS, Chen B, Aboukameel A, Mohammad RM. Al-Katib AM, et al. Among authors: goustin as. J Hematol Oncol. 2009 Feb 16;2:8. doi: 10.1186/1756-8722-2-8. J Hematol Oncol. 2009. PMID: 19220884 Free PMC article.
Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene.
Mathews ST, Singh GP, Ranalletta M, Cintron VJ, Qiang X, Goustin AS, Jen KL, Charron MJ, Jahnen-Dechent W, Grunberger G. Mathews ST, et al. Among authors: goustin as. Diabetes. 2002 Aug;51(8):2450-8. doi: 10.2337/diabetes.51.8.2450. Diabetes. 2002. PMID: 12145157
Reactivation of p53 by novel MDM2 inhibitors: implications for pancreatic cancer therapy.
Azmi AS, Philip PA, Aboukameel A, Wang Z, Banerjee S, Zafar SF, Goustin AS, Almhanna K, Yang D, Sarkar FH, Mohammad RM. Azmi AS, et al. Among authors: goustin as. Curr Cancer Drug Targets. 2010 May;10(3):319-31. doi: 10.2174/156800910791190229. Curr Cancer Drug Targets. 2010. PMID: 20370686 Free PMC article.
Alpha2-HSG, a specific inhibitor of insulin receptor autophosphorylation, interacts with the insulin receptor.
Mathews ST, Chellam N, Srinivas PR, Cintron VJ, Leon MA, Goustin AS, Grunberger G. Mathews ST, et al. Among authors: goustin as. Mol Cell Endocrinol. 2000 Jun;164(1-2):87-98. doi: 10.1016/s0303-7207(00)00237-9. Mol Cell Endocrinol. 2000. PMID: 11026561
Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level.
Srinivas PR, Wagner AS, Reddy LV, Deutsch DD, Leon MA, Goustin AS, Grunberger G. Srinivas PR, et al. Among authors: goustin as. Mol Endocrinol. 1993 Nov;7(11):1445-55. doi: 10.1210/mend.7.11.7906861. Mol Endocrinol. 1993. PMID: 7906861
The "thrifty" gene encoding Ahsg/Fetuin-A meets the insulin receptor: Insights into the mechanism of insulin resistance.
Goustin AS, Abou-Samra AB. Goustin AS, et al. Cell Signal. 2011 Jun;23(6):980-90. doi: 10.1016/j.cellsig.2010.11.003. Epub 2010 Nov 16. Cell Signal. 2011. PMID: 21087662 Review.
Ahsg-fetuin blocks the metabolic arm of insulin action through its interaction with the 95-kD β-subunit of the insulin receptor.
Goustin AS, Derar N, Abou-Samra AB. Goustin AS, et al. Cell Signal. 2013 Apr;25(4):981-8. doi: 10.1016/j.cellsig.2012.12.011. Epub 2013 Jan 11. Cell Signal. 2013. PMID: 23314177
Baculoviral expression of a natural inhibitor of the human insulin receptor tyrosine kinase.
Srinivas PR, Goustin AS, Grunberger G. Srinivas PR, et al. Among authors: goustin as. Biochem Biophys Res Commun. 1995 Mar 17;208(2):879-85. doi: 10.1006/bbrc.1995.1417. Biochem Biophys Res Commun. 1995. PMID: 7695646
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