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Translational control by MAPK signaling in long-term synaptic plasticity and memory.
Kelleher RJ 3rd, Govindarajan A, Jung HY, Kang H, Tonegawa S. Kelleher RJ 3rd, et al. Among authors: govindarajan a. Cell. 2004 Feb 6;116(3):467-79. doi: 10.1016/s0092-8674(04)00115-1. Cell. 2004. PMID: 15016380
Conditional expression of a dominant-negative form of MEK1 in the postnatal murine forebrain inhibited ERK activation and caused selective deficits in hippocampal memory retention and the translation-dependent, transcription-independent phase of hippocampal L-LTP. ...These …
Conditional expression of a dominant-negative form of MEK1 in the postnatal murine forebrain inhibited ERK activation and caused sele …
Enhancement of learning and memory by elevating brain magnesium.
Slutsky I, Abumaria N, Wu LJ, Huang C, Zhang L, Li B, Zhao X, Govindarajan A, Zhao MG, Zhuo M, Tonegawa S, Liu G. Slutsky I, et al. Among authors: govindarajan a. Neuron. 2010 Jan 28;65(2):165-77. doi: 10.1016/j.neuron.2009.12.026. Neuron. 2010. PMID: 20152124
Here, we show that increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, MgT) leads to the enhancement of learning abilities, working memory, and short- and long-term memory in rats. ...
Here, we show that increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, MgT) leads to the en …
The dendritic branch is the preferred integrative unit for protein synthesis-dependent LTP.
Govindarajan A, Israely I, Huang SY, Tonegawa S. Govindarajan A, et al. Neuron. 2011 Jan 13;69(1):132-46. doi: 10.1016/j.neuron.2010.12.008. Neuron. 2011. PMID: 21220104 Free PMC article.
Additionally, L-LTP formation is itself biased toward occurring on spines within a branch. These data support the Clustered Plasticity Hypothesis, which states that such spatial and temporal limits lead to stable engram formation, preferentially at synapses clustered withi …
Additionally, L-LTP formation is itself biased toward occurring on spines within a branch. These data support the Clustered Plasticit …
Optogenetic stimulation of a hippocampal engram activates fear memory recall.
Liu X, Ramirez S, Pang PT, Puryear CB, Govindarajan A, Deisseroth K, Tonegawa S. Liu X, et al. Among authors: govindarajan a. Nature. 2012 Mar 22;484(7394):381-5. doi: 10.1038/nature11028. Nature. 2012. PMID: 22441246 Free PMC article.
A specific memory is thought to be encoded by a sparse population of neurons. These neurons can be tagged during learning for subsequent identification and manipulation. ...Together, our findings indicate that activating a sparse but specific ensemble of hipp
A specific memory is thought to be encoded by a sparse population of neurons. These neurons can be tagged during learning for
Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects.
Govindarajan A, Rao BS, Nair D, Trinh M, Mawjee N, Tonegawa S, Chattarji S. Govindarajan A, et al. Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13208-13. doi: 10.1073/pnas.0605180103. Epub 2006 Aug 21. Proc Natl Acad Sci U S A. 2006. PMID: 16924103 Free PMC article.
Moreover, anxiogenesis and amygdalar spinogenesis are also triggered by chronic stress in control mice but are occluded by BDNF overexpression, thereby suggesting a role for BDNF signaling in stress-induced plasticity in the amygdala. ...
Moreover, anxiogenesis and amygdalar spinogenesis are also triggered by chronic stress in control mice but are occluded by BDNF overexpressi …
A clustered plasticity model of long-term memory engrams.
Govindarajan A, Kelleher RJ, Tonegawa S. Govindarajan A, et al. Nat Rev Neurosci. 2006 Jul;7(7):575-83. doi: 10.1038/nrn1937. Nat Rev Neurosci. 2006. PMID: 16791146 Review.
On the basis of recent data on translation-dependent synaptic plasticity and on the supralinear effect of activation of nearby synapses on action potential generation, we propose a model for the formation of long-term memory engrams at the single neuron level. In this mode …
On the basis of recent data on translation-dependent synaptic plasticity and on the supralinear effect of activation of nearby synapses on a …
Translational regulatory mechanisms in persistent forms of synaptic plasticity.
Kelleher RJ 3rd, Govindarajan A, Tonegawa S. Kelleher RJ 3rd, et al. Among authors: govindarajan a. Neuron. 2004 Sep 30;44(1):59-73. doi: 10.1016/j.neuron.2004.09.013. Neuron. 2004. PMID: 15450160 Review.
However, a growing body of evidence now supports a crucial role for neuronal activity-dependent mRNA translation, which may occur in dendrites for a subset of neuronal mRNAs. ...Rapid enhancement of the synthesis of a diverse array of neuronal proteins …
However, a growing body of evidence now supports a crucial role for neuronal activity-dependent mRNA translation, which may oc …
The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration.
Chen D, Steele AD, Hutter G, Bruno J, Govindarajan A, Easlon E, Lin SJ, Aguzzi A, Lindquist S, Guarente L. Chen D, et al. Among authors: govindarajan a. Exp Gerontol. 2008 Dec;43(12):1086-93. doi: 10.1016/j.exger.2008.08.050. Epub 2008 Aug 30. Exp Gerontol. 2008. PMID: 18799131 Free PMC article.
A central focus of aging research is to determine how calorie restriction (CR) extends lifespan and delays diseases of aging. ...In addition, SIRT1 plays a protective role in several models of neurodegenerative disease. We tested the role of SIRT1 in mediating the e
A central focus of aging research is to determine how calorie restriction (CR) extends lifespan and delays diseases of aging. ...In a
Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.
Dolan BM, Duron SG, Campbell DA, Vollrath B, Shankaranarayana Rao BS, Ko HY, Lin GG, Govindarajan A, Choi SY, Tonegawa S. Dolan BM, et al. Among authors: govindarajan a. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5671-6. doi: 10.1073/pnas.1219383110. Epub 2013 Mar 18. Proc Natl Acad Sci U S A. 2013. PMID: 23509247 Free PMC article.
Here we take a hypothesis-driven, mechanism-based approach to the search for an effective therapy for FXS. We hypothesize that a treatment that rescues the dendritic spine defect in Fmr1 KO mice may also ameliorate autism-like behavioral symptoms. Thus, we targeted …
Here we take a hypothesis-driven, mechanism-based approach to the search for an effective therapy for FXS. We hypothesize that a
Size of bacterial ice-nucleation sites measured in situ by radiation inactivation analysis.
Govindarajan AG, Lindow SE. Govindarajan AG, et al. Proc Natl Acad Sci U S A. 1988 Mar;85(5):1334-8. doi: 10.1073/pnas.85.5.1334. Proc Natl Acad Sci U S A. 1988. PMID: 16593912 Free PMC article.
Lyophilized cells of each bacterial strain were irradiated with a flux of gamma radiation from 0 to 10.2 Mrad (1 Mrad = 10(6) J/kg). ...The minimum mass of a functional ice nucleus, active only between -12 degrees C and -13 degrees C, was about 150 kDa for all strai …
Lyophilized cells of each bacterial strain were irradiated with a flux of gamma radiation from 0 to 10.2 Mrad (1 Mrad = 10(6) J/kg). …
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