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Glucocorticoid receptor isoform-specific regulation of development, circadian rhythm, and inflammation in mice.
Oakley RH, Ramamoorthy S, Foley JF, Busada JT, Lu NZ, Cidlowski JA. Oakley RH, et al. FASEB J. 2018 Oct;32(10):5258-5271. doi: 10.1096/fj.201701153R. Epub 2018 Apr 19. FASEB J. 2018. PMID: 29672221 Free PMC article.
We have generated knockin mice that exclusively express the most active receptor isoform, GR-C3. GR-C3 knockin mice die at birth due to respiratory distress. Microarray analysis of fibroblasts from wild-type and GR-C3 mice indicated that …
We have generated knockin mice that exclusively express the most active receptor isoform, GR-C3. GR-C3 knockin m …
Selective glucocorticoid receptor translational isoforms reveal glucocorticoid-induced apoptotic transcriptomes.
Wu I, Shin SC, Cao Y, Bender IK, Jafari N, Feng G, Lin S, Cidlowski JA, Schleimer RP, Lu NZ. Wu I, et al. Cell Death Dis. 2013 Jan 10;4(1):e453. doi: 10.1038/cddis.2012.193. Cell Death Dis. 2013. PMID: 23303127 Free PMC article.
DEX induced apoptosis in cells expressing the GR-A, -B, or -C, but not the GR-D, isoform. cDNA microarray analyses of cells sensitive (GR-C3) and insensitive (GR-D3) to DEX revealed glucocorticoid-induced proapoptotic transcriptomes. Genes that were regulated by the …
DEX induced apoptosis in cells expressing the GR-A, -B, or -C, but not the GR-D, isoform. cDNA microarray analyses of cells sensitive (GR …