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Administration of growth hormone and nandrolone decanoate alters mRNA expression of the GABAB receptor subunits as well as of the GH receptor, IGF-1, and IGF-2 in rat brain.
Grönbladh A, Johansson J, Nyberg F, Hallberg M. Grönbladh A, et al. Growth Horm IGF Res. 2014 Apr-Jun;24(2-3):60-6. doi: 10.1016/j.ghir.2014.01.002. Epub 2014 Jan 16. Growth Horm IGF Res. 2014. PMID: 24480470
The GABAergic system is implicated in actions induced by AAS and previous studies have provided evidence for a link between GH and GABAB receptors in the brain. ...DESIGN: The aim was to investigate the CNS effects of a high-dose ND, and to study if a low, bu …
The GABAergic system is implicated in actions induced by AAS and previous studies have provided evidence for a link between GH and GA …
Recombinant human growth hormone affects the density and functionality of GABAB receptors in the male rat brain.
Grönbladh A, Johansson J, Nyberg F, Hallberg M. Grönbladh A, et al. Neuroendocrinology. 2013;97(3):203-11. doi: 10.1159/000339821. Epub 2012 Aug 25. Neuroendocrinology. 2013. PMID: 22710737
The results demonstrate moderate but significant alterations in both receptor density and functionality in a number of brain regions. For example, a dose-dependent upregulation of GABAB receptors was found in the cingulate cortex, primary motor cortex and caudate pu …
The results demonstrate moderate but significant alterations in both receptor density and functionality in a number of brain regions. …
The expression of growth hormone receptor gene transcript in the prefrontal cortex is affected in male mice with diabetes-induced learning impairments.
Enhamre E, Carlsson A, Grönbladh A, Watanabe H, Hallberg M, Nyberg F. Enhamre E, et al. Among authors: gronbladh a. Neurosci Lett. 2012 Aug 8;523(1):82-6. doi: 10.1016/j.neulet.2012.06.050. Epub 2012 Jun 27. Neurosci Lett. 2012. PMID: 22750159
In addition, there was a significant correlation between the expression of GHR mRNA and performance in the BM during the acquisition phase in diabetic but not control mice. ...
In addition, there was a significant correlation between the expression of GHR mRNA and performance in the BM during the acquisition …
Application of in vitro [³⁵S]GTPγ-S autoradiography in studies of growth hormone effects on opioid receptors in the male rat brain.
Johansson J, Grönbladh A, Nyberg F, Hallberg M. Johansson J, et al. Among authors: gronbladh a. Brain Res Bull. 2013 Jan;90:100-6. doi: 10.1016/j.brainresbull.2012.09.008. Epub 2012 Oct 11. Brain Res Bull. 2013. PMID: 23063719
Thus, the data support that the beneficial effect of GH on counteracting apoptosis might involve a direct or indirect effect on the MOP but not the DOP receptor....
Thus, the data support that the beneficial effect of GH on counteracting apoptosis might involve a direct or indirect effect on the M …
GH improves spatial memory and reverses certain anabolic androgenic steroid-induced effects in intact rats.
Grönbladh A, Johansson J, Nöstl A, Nyberg F, Hallberg M. Grönbladh A, et al. J Endocrinol. 2013 Jan 2;216(1):31-41. doi: 10.1530/JOE-12-0315. Print 2013 Jan. J Endocrinol. 2013. PMID: 23092877
The results demonstrated a significant positive effect of GH on memory functions and increased gene expression of Igf1 in the hippocampus was found in the animals treated with GH. ...
The results demonstrated a significant positive effect of GH on memory functions and increased gene expression of Igf1 in the hippoca …
The impact of nandrolone decanoate and growth hormone on biosynthesis of steroids in rats.
Grönbladh A, Johansson J, Kushnir MM, Bergquist J, Hallberg M. Grönbladh A, et al. Steroids. 2013 Dec 11;78(12-13):1192-9. doi: 10.1016/j.steroids.2013.08.012. Epub 2013 Sep 5. Steroids. 2013. PMID: 24012727
Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids.
Rhodin A, von Ehren M, Skottheim B, Grönbladh A, Ortiz-Nieto F, Raininko R, Gordh T, Nyberg F. Rhodin A, et al. Among authors: gronbladh a. Acta Anaesthesiol Scand. 2014 Jul;58(6):759-65. doi: 10.1111/aas.12309. Epub 2014 Apr 8. Acta Anaesthesiol Scand. 2014. PMID: 24712862 Free PMC article.
In this report, a patient with cognitive disabilities resulting from chronic treatment with opioids for neuropathic pain received recombinant human growth hormone (rhGH) replacement therapy. A 61-year-old man presented with severe cognitive dysfunction after long-te …
In this report, a patient with cognitive disabilities resulting from chronic treatment with opioids for neuropathic pain received rec …
Gamma-hydroxybutyrate (GHB) induces cognitive deficits and affects GABAB receptors and IGF-1 receptors in male rats.
Johansson J, Grönbladh A, Hallberg M. Johansson J, et al. Among authors: gronbladh a. Behav Brain Res. 2014 Aug 1;269:164-74. doi: 10.1016/j.bbr.2014.04.034. Epub 2014 Apr 28. Behav Brain Res. 2014. PMID: 24786330
The present study investigates the impact of GHB treatment on spatial learning and memory using a water maze (WM) test in rats. ...
The present study investigates the impact of GHB treatment on spatial learning and memory using a water maze (WM) test in rats. ...
[(35)S]GTPγS autoradiography for studies of opioid receptor functionality.
Grönbladh A, Hallberg M. Grönbladh A, et al. Methods Mol Biol. 2015;1230:169-76. doi: 10.1007/978-1-4939-1708-2_13. Methods Mol Biol. 2015. PMID: 25293324
When a ligand binds to the receptor GTP will replace GDP on the α-subunit of the G protein, leading to a dissociation of the βγ-subunit. These subunits will start a cascade of second messengers and subsequently a physiological response....
When a ligand binds to the receptor GTP will replace GDP on the α-subunit of the G protein, leading to a dissociation of the β …
The neurobiology and addiction potential of anabolic androgenic steroids and the effects of growth hormone.
Grönbladh A, Nylander E, Hallberg M. Grönbladh A, et al. Brain Res Bull. 2016 Sep;126(Pt 1):127-137. doi: 10.1016/j.brainresbull.2016.05.003. Epub 2016 May 5. Brain Res Bull. 2016. PMID: 27156843 Review.
In addition to their physiological effect on muscle tissue and growth, research from the last decade has shown that AAS have a pronounced impact on the central nervous system. ...Therefore, a large section on growth hormone and insulin-like growth factor is also inc …
In addition to their physiological effect on muscle tissue and growth, research from the last decade has shown that AAS have a pronou …
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