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The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis.
Yenush L, Fernandez R, Myers MG Jr, Grammer TC, Sun XJ, Blenis J, Pierce JH, Schlessinger J, White MF. Yenush L, et al. Mol Cell Biol. 1996 May;16(5):2509-17. doi: 10.1128/mcb.16.5.2509. Mol Cell Biol. 1996. PMID: 8628319 Free PMC article.
Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.
Monfar M, Lemon KP, Grammer TC, Cheatham L, Chung J, Vlahos CJ, Blenis J. Monfar M, et al. Mol Cell Biol. 1995 Jan;15(1):326-37. doi: 10.1128/mcb.15.1.326. Mol Cell Biol. 1995. PMID: 7528328 Free PMC article.
Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.
Myers MG Jr, Grammer TC, Wang LM, Sun XJ, Pierce JH, Blenis J, White MF. Myers MG Jr, et al. J Biol Chem. 1994 Nov 18;269(46):28783-9. J Biol Chem. 1994. PMID: 7961833
YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites.
Myers MG Jr, Zhang Y, Aldaz GA, Grammer T, Glasheen EM, Yenush L, Wang LM, Sun XJ, Blenis J, Pierce JH, White MF. Myers MG Jr, et al. Mol Cell Biol. 1996 Aug;16(8):4147-55. doi: 10.1128/mcb.16.8.4147. Mol Cell Biol. 1996. PMID: 8754813 Free PMC article.
The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling.
Myers MG Jr, Grammer TC, Brooks J, Glasheen EM, Wang LM, Sun XJ, Blenis J, Pierce JH, White MF. Myers MG Jr, et al. J Biol Chem. 1995 May 19;270(20):11715-8. doi: 10.1074/jbc.270.20.11715. J Biol Chem. 1995. PMID: 7744813
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