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Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism.
Granfors MT, Backman JT, Neuvonen M, Neuvonen PJ. Granfors MT, et al. Clin Pharmacol Ther. 2004 Dec;76(6):598-606. doi: 10.1016/j.clpt.2004.08.018. Clin Pharmacol Ther. 2004. PMID: 15592331 Clinical Trial.
Rifampicin is only a weak inducer of CYP1A2-mediated presystemic and systemic metabolism: studies with tizanidine and caffeine.
Backman JT, Granfors MT, Neuvonen PJ. Backman JT, et al. Among authors: granfors mt. Eur J Clin Pharmacol. 2006 Jun;62(6):451-61. doi: 10.1007/s00228-006-0127-x. Epub 2006 Apr 27. Eur J Clin Pharmacol. 2006. PMID: 16758262 Clinical Trial.
Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro.
Granfors MT, Wang JS, Kajosaari LI, Laitila J, Neuvonen PJ, Backman JT. Granfors MT, et al. Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):79-85. doi: 10.1111/j.1742-7843.2006.pto_249.x. Basic Clin Pharmacol Toxicol. 2006. PMID: 16433896 Free article.
Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2.
Granfors MT, Backman JT, Laitila J, Neuvonen PJ. Granfors MT, et al. Clin Pharmacol Ther. 2005 Oct;78(4):400-11. doi: 10.1016/j.clpt.2005.06.009. Clin Pharmacol Ther. 2005. PMID: 16198659 Clinical Trial.
Tizanidine is mainly metabolized by cytochrome p450 1A2 in vitro.
Granfors MT, Backman JT, Laitila J, Neuvonen PJ. Granfors MT, et al. Br J Clin Pharmacol. 2004 Mar;57(3):349-53. doi: 10.1046/j.1365-2125.2003.02028.x. Br J Clin Pharmacol. 2004. PMID: 14998432 Free PMC article.
Fluvoxamine drastically increases concentrations and effects of tizanidine: a potentially hazardous interaction.
Granfors MT, Backman JT, Neuvonen M, Ahonen J, Neuvonen PJ. Granfors MT, et al. Clin Pharmacol Ther. 2004 Apr;75(4):331-41. doi: 10.1016/j.clpt.2003.12.005. Clin Pharmacol Ther. 2004. PMID: 15060511 Clinical Trial.
Gemfibrozil considerably increases the plasma concentrations of rosiglitazone.
Niemi M, Backman JT, Granfors M, Laitila J, Neuvonen M, Neuvonen PJ. Niemi M, et al. Diabetologia. 2003 Oct;46(10):1319-23. doi: 10.1007/s00125-003-1181-x. Epub 2003 Jul 29. Diabetologia. 2003. PMID: 12898007 Clinical Trial.