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1990 1
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91 results

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Page 1
Endosomal microdomains: Formation and function.
Norris A, Grant BD. Norris A, et al. Among authors: grant bd. Curr Opin Cell Biol. 2020 Aug;65:86-95. doi: 10.1016/j.ceb.2020.02.018. Epub 2020 Apr 1. Curr Opin Cell Biol. 2020. PMID: 32247230 Free PMC article. Review.
It is widely recognized that after endocytosis, internalized cargo is delivered to endosomes that act as sorting stations. The limiting membrane of endosomes contain specialized subregions, or microdomains, that represent distinct functions of the endosome
It is widely recognized that after endocytosis, internalized cargo is delivered to endosomes that act as sorting stations. The …
Intracellular trafficking.
Grant BD, Sato M. Grant BD, et al. WormBook. 2006 Jan 21:1-9. doi: 10.1895/wormbook.1.77.1. WormBook. 2006. PMID: 18050485 Free PMC article. Review.
Studies in C. elegans have begun to reveal new components and new mechanisms associated with intracellular membrane traffic in a variety of cell types. ...
Studies in C. elegans have begun to reveal new components and new mechanisms associated with intracellular membrane traffic in a vari …
Conserved NIMA kinases regulate multiple steps of endocytic trafficking.
Joseph BB, Naslavsky N, Binti S, Conquest S, Robison L, Bai G, Homer RO, Grant BD, Caplan S, Fay DS. Joseph BB, et al. Among authors: grant bd. PLoS Genet. 2023 Apr 26;19(4):e1010741. doi: 10.1371/journal.pgen.1010741. eCollection 2023 Apr. PLoS Genet. 2023. PMID: 37099601 Free PMC article.
Human NIMA-related kinases have primarily been studied for their roles in cell cycle progression (NEK1/2/6/7/9), checkpoint-DNA-damage control (NEK1/2/4/5/10/11), and ciliogenesis (NEK1/4/8). We previously showed that Caenorhabditis elegans NEKL-2 (NEK8/9 homolog) and NEKL …
Human NIMA-related kinases have primarily been studied for their roles in cell cycle progression (NEK1/2/6/7/9), checkpoint-DNA-damage contr …
Macrocephaly and developmental delay caused by missense variants in RAB5C.
Koop K, Yuan W, Tessadori F, Rodriguez-Polanco WR, Grubbs J, Zhang B, Osmond M, Graham G, Sawyer S, Conboy E, Vetrini F, Treat K, Płoski R, Pienkowski VM, Kłosowska A, Fieg E, Krier J, Mallebranche C, Alban Z, Aldinger KA, Ritter D, Macnamara E, Sullivan B, Herriges J, Alaimo JT, Helbig C, Ellis CA, van Eyk C, Gecz J, Farrugia D, Osei-Owusu I, Adès L, van den Boogaard MJ, Fuchs S, Bakker J, Duran K, Dawson ZD, Lindsey A, Huang H, Baldridge D, Silverman GA, Grant BD, Raizen D; Undiagnosed Diseases Network; van Haaften G, Pak SC, Rehmann H, Schedl T, van Hasselt P. Koop K, et al. Among authors: grant bd. Hum Mol Genet. 2023 Oct 17;32(21):3063-3077. doi: 10.1093/hmg/ddad130. Hum Mol Genet. 2023. PMID: 37552066 Free PMC article.
In vitro biochemical studies revealed that all four variants were damaging, resulting in increased nucleotide exchange rate, attenuated responsivity to guanine exchange factors and heterogeneous effects on interactions with effector proteins. Studies in C. elegans confirme …
In vitro biochemical studies revealed that all four variants were damaging, resulting in increased nucleotide exchange rate, attenuated resp …
A Conserved Requirement for RME-8/DNAJC13 in Neuronal Autolysosome Reformation.
Swords S, Jia N, Norris A, Modi J, Cai Q, Grant BD. Swords S, et al. Among authors: grant bd. bioRxiv [Preprint]. 2023 Feb 28:2023.02.27.530319. doi: 10.1101/2023.02.27.530319. bioRxiv. 2023. PMID: 36909501 Free PMC article. Updated. Preprint.
Clathrin is also an important ALR regulator implicated in autolysosome tubule formation and release. In C. elegans we found that loss of RME-8 causes severe depletion of clathrin from neuronal autolysosomes, a phenotype shared with bec-1 and vps-15 mutants. .
Clathrin is also an important ALR regulator implicated in autolysosome tubule formation and release. In C. elegans we found th
A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation.
Swords SB, Jia N, Norris A, Modi J, Cai Q, Grant BD. Swords SB, et al. Among authors: grant bd. Autophagy. 2023 Nov 9:1-17. doi: 10.1080/15548627.2023.2269028. Online ahead of print. Autophagy. 2023. PMID: 37942902
The DNA-J domain HSC70 co-chaperone RME-8/DNAJC13 has been linked to endosomal coat protein regulation and to neurological disease. We report new analysis of the requirements for the RME-8/DNAJC13 protein in neurons, focusing on intact C. elegans mechanosensory neur …
The DNA-J domain HSC70 co-chaperone RME-8/DNAJC13 has been linked to endosomal coat protein regulation and to neurological disease. W …
C. elegans as a model for membrane traffic.
Sato K, Norris A, Sato M, Grant BD. Sato K, et al. Among authors: grant bd. WormBook. 2014 Apr 25:1-47. doi: 10.1895/wormbook.1.77.2. WormBook. 2014. PMID: 24778088 Free PMC article. Review.
The counterbalancing action of the endocytosis and secretory pathways maintains a dynamic equilibrium that regulates the composition of the plasma membrane, allowing it to maintain homeostasis and to change rapidly in response to alterations in the extracellular environmen …
The counterbalancing action of the endocytosis and secretory pathways maintains a dynamic equilibrium that regulates the composition …
Large vesicle extrusions from C. elegans neurons are consumed and stimulated by glial-like phagocytosis activity of the neighboring cell.
Wang Y, Arnold ML, Smart AJ, Wang G, Androwski RJ, Morera A, Nguyen KCQ, Schweinsberg PJ, Bai G, Cooper J, Hall DH, Driscoll M, Grant BD. Wang Y, et al. Among authors: grant bd. Elife. 2023 Mar 2;12:e82227. doi: 10.7554/eLife.82227. Elife. 2023. PMID: 36861960 Free PMC article.
Caenorhabditis elegans neurons under stress can produce giant vesicles, several microns in diameter, called exophers. ...We found that exophers produced by mechanosensory neurons in C. elegans are engulfed by surrounding hypodermal skin cells and are then broken up …
Caenorhabditis elegans neurons under stress can produce giant vesicles, several microns in diameter, called exophers. ...We found tha …
Control of clathrin-mediated endocytosis by NIMA family kinases.
Joseph BB, Wang Y, Edeen P, Lažetić V, Grant BD, Fay DS. Joseph BB, et al. Among authors: grant bd. PLoS Genet. 2020 Feb 18;16(2):e1008633. doi: 10.1371/journal.pgen.1008633. eCollection 2020 Feb. PLoS Genet. 2020. PMID: 32069276 Free PMC article.
Here we show that the conserved NIMA-related kinases NEKL-2/NEK8/9 and NEKL-3/NEK6/7 (the NEKLs) control clathrin-mediated endocytosis in C. elegans. Loss of NEKL-2 or NEKL-3 activities leads to penetrant larval molting defects and to the abnormal localizatio …
Here we show that the conserved NIMA-related kinases NEKL-2/NEK8/9 and NEKL-3/NEK6/7 (the NEKLs) control clathrin-mediated endocyt
Deciphering endocytosis in Caenorhabditis elegans.
Fares H, Grant B. Fares H, et al. Among authors: grant b. Traffic. 2002 Jan;3(1):11-9. doi: 10.1034/j.1600-0854.2002.30103.x. Traffic. 2002. PMID: 11872138 Free article. Review.
New studies in C. elegans have used a combination of these techniques to reveal novel metazoan-specific trafficking factors required for endocytosis. Many more metazoan-specific trafficking factors and insights into the mechanisms of endocytosis are likely to …
New studies in C. elegans have used a combination of these techniques to reveal novel metazoan-specific trafficking factors required …
91 results