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Page 1
The neuropathological diagnosis of Alzheimer's disease.
DeTure MA, Dickson DW. DeTure MA, et al. Mol Neurodegener. 2019 Aug 2;14(1):32. doi: 10.1186/s13024-019-0333-5. Mol Neurodegener. 2019. PMID: 31375134 Free PMC article. Review.
This review outlines etiologically-linked pathologic features of Alzheimer's disease, as well as those that are inevitable findings of uncertain significance, such as granulovacuolar degeneration and Hirano bodies. Other disease processes that are frequent, but not …
This review outlines etiologically-linked pathologic features of Alzheimer's disease, as well as those that are inevitable findings of uncer …
Alzheimer disease.
Calderon-Garcidueñas AL, Duyckaerts C. Calderon-Garcidueñas AL, et al. Handb Clin Neurol. 2017;145:325-337. doi: 10.1016/B978-0-12-802395-2.00023-7. Handb Clin Neurol. 2017. PMID: 28987180 Review.
Loss of synapses is observed in association with tau and Abeta pathology; neuronal loss occurs in the most affected areas. Granulovacuolar degeneration and perisomatic granules are also linked to Alzheimer disease pathology. ...
Loss of synapses is observed in association with tau and Abeta pathology; neuronal loss occurs in the most affected areas. Granulovacuola …
Is granulovacuolar degeneration an essential pathological component of Alzheimer's disease? A review of the pathogenesis and histochemistry of old studies.
Kurdi M, Alghamdi B. Kurdi M, et al. Folia Neuropathol. 2020;58(4):277-286. doi: 10.5114/fn.2020.102429. Folia Neuropathol. 2020. PMID: 33480232 Free article. Review.
Granulovacuolar degeneration (GVD) is a histopathological feature of Alzheimer's disease (AD) and some non-Alzheimer neurodegenerative diseases. ...
Granulovacuolar degeneration (GVD) is a histopathological feature of Alzheimer's disease (AD) and some non-Alzheimer neurodege …
Untangling the origin and function of granulovacuolar degeneration bodies in neurodegenerative proteinopathies.
Wiersma VI, Hoozemans JJM, Scheper W. Wiersma VI, et al. Acta Neuropathol Commun. 2020 Sep 3;8(1):153. doi: 10.1186/s40478-020-00996-5. Acta Neuropathol Commun. 2020. PMID: 32883341 Free PMC article. Review.
In the brains of tauopathy patients, tau pathology coincides with the presence of granulovacuolar degeneration bodies (GVBs) both at the regional and cellular level. ...
In the brains of tauopathy patients, tau pathology coincides with the presence of granulovacuolar degeneration bodies (GVBs) b …
Granulovacuolar degeneration bodies: red alert for neurons with MAPT/tau pathology.
Wiersma VI, Scheper W. Wiersma VI, et al. Autophagy. 2020 Jan;16(1):173-175. doi: 10.1080/15548627.2019.1680217. Epub 2019 Oct 23. Autophagy. 2020. PMID: 31613164 Free PMC article. Review.
In Alzheimer disease patients, MAPT/tau pathology and granulovacuolar degeneration bodies (GVBs) co-occur in the same brain regions and in the same cells. ...
In Alzheimer disease patients, MAPT/tau pathology and granulovacuolar degeneration bodies (GVBs) co-occur in the same brain re …
Granulovacuolar degeneration: a neurodegenerative change that accompanies tau pathology.
Köhler C. Köhler C. Acta Neuropathol. 2016 Sep;132(3):339-59. doi: 10.1007/s00401-016-1562-0. Epub 2016 Apr 9. Acta Neuropathol. 2016. PMID: 27062260 Review.
Granule-containing vacuoles in the cytoplasm of hippocampal neurons are a neuropathological feature of Alzheimer's disease. Granulovacuolar degeneration (GVD) is not disease-specific and can be observed in other neurodegenerative disorders and even in the brains of …
Granule-containing vacuoles in the cytoplasm of hippocampal neurons are a neuropathological feature of Alzheimer's disease. Granulovacuol …
Necroptosis and Alzheimer's Disease: Pathogenic Mechanisms and Therapeutic Opportunities.
Zhang R, Song Y, Su X. Zhang R, et al. J Alzheimers Dis. 2023;94(s1):S367-S386. doi: 10.3233/JAD-220809. J Alzheimers Dis. 2023. PMID: 36463451 Free PMC article. Review.
The keywords in the search included: "necroptosis", "Alzheimer's disease", "signaling pathways", "Abeta", Abetao", "Tau", "p-Tau", "neuronal death", "BBB damage", "neuroinflammation", "microglia", "mitochondrial dysfunction", "granulovacuolar degeneration", "synapti …
The keywords in the search included: "necroptosis", "Alzheimer's disease", "signaling pathways", "Abeta", Abetao", "Tau", "p-Tau", "neuronal …
Tau interactome and RNA binding proteins in neurodegenerative diseases.
Kavanagh T, Halder A, Drummond E. Kavanagh T, et al. Mol Neurodegener. 2022 Oct 17;17(1):66. doi: 10.1186/s13024-022-00572-6. Mol Neurodegener. 2022. PMID: 36253823 Free PMC article. Review.
We also performed a second analysis to identify the tau interacting proteins that are enriched in neurons containing granulovacuolar degeneration or neurofibrillary tangle pathology. These results revealed a timed dysregulation of tau interactions as pathology devel …
We also performed a second analysis to identify the tau interacting proteins that are enriched in neurons containing granulovacuolar …
Neuropathology of Alzheimer's disease.
Perl DP. Perl DP. Mt Sinai J Med. 2010 Jan-Feb;77(1):32-42. doi: 10.1002/msj.20157. Mt Sinai J Med. 2010. PMID: 20101720 Free PMC article. Review.
Other lesions include poorly understood changes such as granulovacuolar degeneration and eosinophilic rodlike bodies (Hirano bodies). ...
Other lesions include poorly understood changes such as granulovacuolar degeneration and eosinophilic rodlike bodies (Hirano b …
Pathophysiology of ageing brain.
Davison AN. Davison AN. Gerontology. 1987;33(3-4):129-35. doi: 10.1159/000212866. Gerontology. 1987. PMID: 3308642 Review.
It may be speculated that neurons containing tangles or undergoing granulovacuolar degeneration would not be able to release trophic factors and that transneuronal degeneration would result. ...
It may be speculated that neurons containing tangles or undergoing granulovacuolar degeneration would not be able to release t …
27 results