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Integrin-linked kinase: integrin's mysterious partner.
Grashoff C, Thievessen I, Lorenz K, Ussar S, Fässler R. Grashoff C, et al. Curr Opin Cell Biol. 2004 Oct;16(5):565-71. doi: 10.1016/j.ceb.2004.07.004. Curr Opin Cell Biol. 2004. PMID: 15363808 Review.
Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation.
Sakai T, Li S, Docheva D, Grashoff C, Sakai K, Kostka G, Braun A, Pfeifer A, Yurchenco PD, Fässler R. Sakai T, et al. Among authors: grashoff c. Genes Dev. 2003 Apr 1;17(7):926-40. doi: 10.1101/gad.255603. Genes Dev. 2003. PMID: 12670870 Free PMC article.
Integrin-linked kinase regulates chondrocyte shape and proliferation.
Grashoff C, Aszódi A, Sakai T, Hunziker EB, Fässler R. Grashoff C, et al. EMBO Rep. 2003 Apr;4(4):432-8. doi: 10.1038/sj.embor.embor801. EMBO Rep. 2003. PMID: 12671688 Free PMC article.
Integrin-linked kinase is required for epidermal and hair follicle morphogenesis.
Lorenz K, Grashoff C, Torka R, Sakai T, Langbein L, Bloch W, Aumailley M, Fässler R. Lorenz K, et al. Among authors: grashoff c. J Cell Biol. 2007 May 7;177(3):501-13. doi: 10.1083/jcb.200608125. J Cell Biol. 2007. PMID: 17485490 Free PMC article.
Tenascin-C induction by cyclic strain requires integrin-linked kinase.
Maier S, Lutz R, Gelman L, Sarasa-Renedo A, Schenk S, Grashoff C, Chiquet M. Maier S, et al. Among authors: grashoff c. Biochim Biophys Acta. 2008 Jun;1783(6):1150-62. doi: 10.1016/j.bbamcr.2008.01.013. Epub 2008 Jan 26. Biochim Biophys Acta. 2008. PMID: 18269918
Integrin-linked kinase is required for vitronectin-mediated internalization of Streptococcus pneumoniae by host cells.
Bergmann S, Lang A, Rohde M, Agarwal V, Rennemeier C, Grashoff C, Preissner KT, Hammerschmidt S. Bergmann S, et al. Among authors: grashoff c. J Cell Sci. 2009 Jan 15;122(Pt 2):256-67. doi: 10.1242/jcs.035600. J Cell Sci. 2009. PMID: 19118218
Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation.
Stanchi F, Grashoff C, Nguemeni Yonga CF, Grall D, Fässler R, Van Obberghen-Schilling E. Stanchi F, et al. Among authors: grashoff c. J Cell Sci. 2009 Jun 1;122(Pt 11):1800-11. doi: 10.1242/jcs.044602. Epub 2009 May 12. J Cell Sci. 2009. PMID: 19435803
Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography.
Patla I, Volberg T, Elad N, Hirschfeld-Warneken V, Grashoff C, Fässler R, Spatz JP, Geiger B, Medalia O. Patla I, et al. Among authors: grashoff c. Nat Cell Biol. 2010 Sep;12(9):909-15. doi: 10.1038/ncb2095. Epub 2010 Aug 8. Nat Cell Biol. 2010. PMID: 20694000
Induction of membrane circular dorsal ruffles requires co-signalling of integrin-ILK-complex and EGF receptor.
Azimifar SB, Böttcher RT, Zanivan S, Grashoff C, Krüger M, Legate KR, Mann M, Fässler R. Azimifar SB, et al. Among authors: grashoff c. J Cell Sci. 2012 Jan 15;125(Pt 2):435-48. doi: 10.1242/jcs.091652. J Cell Sci. 2012. PMID: 22357970
Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice.
Moik D, Böttcher A, Makhina T, Grashoff C, Bulus N, Zent R, Fässler R. Moik D, et al. Among authors: grashoff c. J Biol Chem. 2013 Jun 28;288(26):18863-71. doi: 10.1074/jbc.M113.470476. Epub 2013 May 8. J Biol Chem. 2013. PMID: 23658024 Free PMC article.
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