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Intranasal delivery of mouse [D-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, improves energy balance, glycaemic control, insulin sensitivity and bone formation in leptin-resistant C57BLK/6-m db/db mice.
Waldrop MA, Leinung MC, Lee DW, Grasso P. Waldrop MA, et al. Among authors: grasso p. Diabetes Obes Metab. 2010 Oct;12(10):871-5. doi: 10.1111/j.1463-1326.2010.01243.x. Diabetes Obes Metab. 2010. PMID: 20920039
Myristic acid conjugation of [D-Leu-4]-OB3, a biologically active leptin-related synthetic peptide amide, significantly improves its pharmacokinetic profile and efficacy.
Novakovic ZM, Anderson BM, Grasso P. Novakovic ZM, et al. Among authors: grasso p. Peptides. 2014 Dec;62:176-82. doi: 10.1016/j.peptides.2014.10.007. Peptides. 2014. PMID: 25453979
[D-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, augments the effects of orally delivered exenatide and pramlintide acetate on energy balance and glycemic control in insulin-resistant male C57BLK/6-m db/db mice.
Leinung MC, Grasso P. Leinung MC, et al. Among authors: grasso p. Regul Pept. 2012 Nov 10;179(1-3):33-8. doi: 10.1016/j.regpep.2012.08.006. Epub 2012 Sep 5. Regul Pept. 2012. PMID: 22960403
[D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, small molecule synthetic peptide leptin mimetics, improve glycemic control in diet-induced obese (DIO) mice.
Wang A, Anderson BM, Novakovic ZM, Grasso P. Wang A, et al. Among authors: grasso p. Peptides. 2018 Mar;101:51-59. doi: 10.1016/j.peptides.2017.12.012. Epub 2017 Dec 19. Peptides. 2018. PMID: 29269073
Oral delivery of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, synthetic peptide leptin mimetics: Immunofluorescent localization in the mouse hypothalamus.
Anderson BM, Jacobson L, Novakovic ZM, Grasso P. Anderson BM, et al. Among authors: grasso p. Brain Res. 2017 Jun 1;1664:1-8. doi: 10.1016/j.brainres.2017.03.020. Epub 2017 Mar 24. Brain Res. 2017. PMID: 28347670
Novel leptin OB3 peptide-induced signaling and progression in thyroid cancers: Comparison with leptin.
Yang YC, Chin YT, Hsieh MT, Lai HY, Ke CC, Crawford DR, Lee OK, Fu E, Mousa SA, Grasso P, Liu LF, Chang HY, Tang HY, Lin HY, Davis PJ. Yang YC, et al. Among authors: grasso p. Oncotarget. 2016 May 10;7(19):27641-54. doi: 10.18632/oncotarget.8505. Oncotarget. 2016. PMID: 27050378 Free PMC article.
Biologically active leptin-related synthetic peptides activate STAT3 via phosphorylation of ERK1/2 and PI-3K.
Lin HY, Yang SH, Tang HY, Cheng GY, Davis PJ, Grasso P. Lin HY, et al. Among authors: grasso p. Peptides. 2014 Jul;57:95-100. doi: 10.1016/j.peptides.2014.04.007. Epub 2014 May 10. Peptides. 2014. PMID: 24819473
[D-Leu-4]-OB3, an orally bioavailable leptin-related synthetic peptide insulin sensitizer: a study comparing the efficacies of [D-Leu-4]-OB3 and metformin on energy balance and glycemic regulation in insulin-deficient male Swiss Webster mice.
Novakovic ZM, Leinung MC, Grasso P. Novakovic ZM, et al. Among authors: grasso p. Peptides. 2013 May;43:167-73. doi: 10.1016/j.peptides.2013.02.023. Epub 2013 Mar 7. Peptides. 2013. PMID: 23500518
Novel approaches to the treatment of obesity and type 2 diabetes mellitus: bioactive leptin-related synthetic peptide analogs.
Grasso P. Grasso P. Recent Pat Endocr Metab Immune Drug Discov. 2011 Sep;5(3):163-75. doi: 10.2174/187221411797265917. Recent Pat Endocr Metab Immune Drug Discov. 2011. PMID: 21913885 Review.
Oral delivery of mouse [D-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, in male Swiss Webster mice: a study comparing the pharmacokinetics of oral delivery to intraperitoneal, subcutaneous, intramuscular, and intranasal administration.
Lee DW, Leinung MC, Grasso P. Lee DW, et al. Among authors: grasso p. Regul Pept. 2010 Feb 25;160(1-3):129-32. doi: 10.1016/j.regpep.2009.12.008. Epub 2009 Dec 22. Regul Pept. 2010. PMID: 20026361
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