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Infection, its treatment and the risk for stroke.
Palm F, Urbanek C, Grau A. Palm F, et al. Curr Vasc Pharmacol. 2009 Apr;7(2):146-52. doi: 10.2174/157016109787455707. Curr Vasc Pharmacol. 2009. PMID: 19355997 Review.
Stroke is among the most common causes of death and persisting disability and therefore represents a great social and economic burden worldwide. ...There is preliminary evidence that the number of pathogens to which a subject had been exposed to rather than single p …
Stroke is among the most common causes of death and persisting disability and therefore represents a great social and economic burden …
Common infections and the risk of stroke.
Grau AJ, Urbanek C, Palm F. Grau AJ, et al. Nat Rev Neurol. 2010 Dec;6(12):681-94. doi: 10.1038/nrneurol.2010.163. Epub 2010 Nov 9. Nat Rev Neurol. 2010. PMID: 21060340 Review.
Data from several case-control studies and one large study using case series methodology indicate that recent infection is a temporarily acting, independent trigger factor for ischemic stroke. ...A causal role for infection in stroke is supported by a graded …
Data from several case-control studies and one large study using case series methodology indicate that recent infection is a temporar …
Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection.
Debette S, Kamatani Y, Metso TM, Kloss M, Chauhan G, Engelter ST, Pezzini A, Thijs V, Markus HS, Dichgans M, Wolf C, Dittrich R, Touzé E, Southerland AM, Samson Y, Abboud S, Béjot Y, Caso V, Bersano A, Gschwendtner A, Sessa M, Cole J, Lamy C, Medeiros E, Beretta S, Bonati LH, Grau AJ, Michel P, Majersik JJ, Sharma P, Kalashnikova L, Nazarova M, Dobrynina L, Bartels E, Guillon B, van den Herik EG, Fernandez-Cadenas I, Jood K, Nalls MA, De Leeuw FE, Jern C, Cheng YC, Werner I, Metso AJ, Lichy C, Lyrer PA, Brandt T, Boncoraglio GB, Wichmann HE, Gieger C, Johnson AD, Böttcher T, Castellano M, Arveiler D, Ikram MA, Breteler MM, Padovani A, Meschia JF, Kuhlenbäumer G, Rolfs A, Worrall BB; International Stroke Genetics Consortium, Ringelstein EB, Zelenika D, Tatlisumak T, Lathrop M, Leys D, Amouyel P, Dallongeville J; CADISP Group. Debette S, et al. Nat Genet. 2015 Jan;47(1):78-83. doi: 10.1038/ng.3154. Epub 2014 Nov 24. Nat Genet. 2015. PMID: 25420145 Free PMC article.
Cervical artery dissection (CeAD), a mural hematoma in a carotid or vertebral artery, is a major cause of ischemic stroke in young adults although relatively uncommon in the general population (incidence of 2.6/100,000 per year). ...
Cervical artery dissection (CeAD), a mural hematoma in a carotid or vertebral artery, is a major cause of ischemic stro …
The association of gingivitis and periodontitis with ischemic stroke.
Dörfer CE, Becher H, Ziegler CM, Kaiser C, Lutz R, Jörss D, Lichy C, Buggle F, Bültmann S, Preusch M, Grau AJ. Dörfer CE, et al. J Clin Periodontol. 2004 May;31(5):396-401. doi: 10.1111/j.1600-051x.2004.00579.x. J Clin Periodontol. 2004. PMID: 15086623
METHODS: In a case-control study, 303 consecutive patients with ischemic stroke or transient ischemic attack, and 300 representative population controls received a complete clinical and radiographic dental examination. ...After adjustment for age, gender, number of …
METHODS: In a case-control study, 303 consecutive patients with ischemic stroke or transient ischemic attack, and 300 representative …
Association between cerebral ischemia and cytotoxin-associated gene-A-bearing strains of Helicobacter pylori.
Preusch MR, Grau AJ, Buggle F, Lichy C, Bartel J, Black C, Rudi J. Preusch MR, et al. Stroke. 2004 Aug;35(8):1800-4. doi: 10.1161/01.STR.0000131751.35926.48. Epub 2004 May 27. Stroke. 2004. PMID: 15166387
Infection with more virulent H. pylori strains, such as cytotoxin-associated gene-A (CagA)-bearing strains, may be of particular relevance for ischemic diseases. ...
Infection with more virulent H. pylori strains, such as cytotoxin-associated gene-A (CagA)-bearing strains, may be of particular rele …
Childhood and adult social conditions and risk of stroke.
Grau AJ, Ling P, Palm F, Urbanek C, Becher H, Buggle F. Grau AJ, et al. Cerebrovasc Dis. 2012;33(4):385-91. doi: 10.1159/000336331. Epub 2012 Mar 28. Cerebrovasc Dis. 2012. PMID: 22456164
A score summarizing 4 lifetime social indexes was not independently associated with stroke risk (OR 0.67, 95% CI 0.39-1.16). ...Stroke preventive strategies may have a particularly large potential if they focus on such lifestyle habits in socially disadvantaged grou
A score summarizing 4 lifetime social indexes was not independently associated with stroke risk (OR 0.67, 95% CI 0.39-1.16). ...Strok
Genetic Imbalance in Patients with Cervical Artery Dissection.
Grond-Ginsbach C, Chen B, Krawczak M, Pjontek R, Ginsbach P, Jiang Y, Abboud S, Arnold ML, Bersano A, Brandt T, Caso V, Debette S, Dichgans M, Geschwendtner A, Giacalone G, Martin JJ, Metso AJ, Metso TM, Grau AJ, Kloss M, Lichy C, Pezzini A, Traenka C, Schreiber S, Thijs V, Touzé E, Del Zotto E, Tatlisumak T, Leys D, Lyrer PA, Engelter ST; CADISP group.. Grond-Ginsbach C, et al. Curr Genomics. 2017 Apr;18(2):206-213. doi: 10.2174/1389202917666160805152627. Curr Genomics. 2017. PMID: 28367076 Free PMC article.
Compared to control subjects, CNVs from CeAD patients were enriched for genes associated with muscle organ development and cell differentiation, which suggests a possible association with arterial development. CNVs affecting cardiovascular system development were more comm …
Compared to control subjects, CNVs from CeAD patients were enriched for genes associated with muscle organ development and cell differentiat …
Genetic Imbalance Is Associated With Functional Outcome After Ischemic Stroke.
Pfeiffer D, Chen B, Schlicht K, Ginsbach P, Abboud S, Bersano A, Bevan S, Brandt T, Caso V, Debette S, Erhart P, Freitag-Wolf S, Giacalone G, Grau AJ, Hayani E, Jern C, Jiménez-Conde J, Kloss M, Krawczak M, Lee JM, Lemmens R, Leys D, Lichy C, Maguire JM, Martin JJ, Metso AJ, Metso TM, Mitchell BD, Pezzini A, Rosand J, Rost NS, Stenman M, Tatlisumak T, Thijs V, Touzé E, Traenka C, Werner I, Woo D, Del Zotto E, Engelter ST, Kittner SJ, Cole JW, Grond-Ginsbach C, Lyrer PA, Lindgren A; CADISP; GISCOME; SiGN studies; and ISGC. Pfeiffer D, et al. Stroke. 2019 Feb;50(2):298-304. doi: 10.1161/STROKEAHA.118.021856. Stroke. 2019. PMID: 30661490 Free PMC article.
Subgroup analyses were confined to patients with imbalance affecting ohnologs-a class of dose-sensitive genes, or to those with imbalance not affecting ohnologs. ...Subgroup analysis revealed that this association was driven by presence of ohnologs in the respective copy n …
Subgroup analyses were confined to patients with imbalance affecting ohnologs-a class of dose-sensitive genes, or to those with imbal …
Socioeconomic Conditions in Childhood, Adolescence, and Adulthood and the Risk of Ischemic Stroke.
Becher H, Palm F, Aigner A, Safer A, Urbanek C, Buggle F, Grond-Ginsbach C, Grau AJ. Becher H, et al. Stroke. 2016 Jan;47(1):173-9. doi: 10.1161/STROKEAHA.115.011523. Epub 2015 Nov 24. Stroke. 2016. PMID: 26604249
METHODS: Within a population-based stroke registry, we performed a case-control study with 470 ischemic stroke patients (cases) aged 18 to 80 years and 809 age- and sex-matched stroke-free controls, randomly selected from the population (study period October 2007 to …
METHODS: Within a population-based stroke registry, we performed a case-control study with 470 ischemic stroke patients (cases …
Demographic and geographic vascular risk factor differences in European young adults with ischemic stroke: the 15 cities young stroke study.
Putaala J, Yesilot N, Waje-Andreassen U, Pitkäniemi J, Vassilopoulou S, Nardi K, Odier C, Hofgart G, Engelter S, Burow A, Mihalka L, Kloss M, Ferrari J, Lemmens R, Coban O, Haapaniemi E, Maaijwee N, Rutten-Jacobs L, Bersano A, Cereda C, Baron P, Borellini L, Valcarenghi C, Thomassen L, Grau AJ, Palm F, Urbanek C, Tuncay R, Durukan-Tolvanen A, van Dijk EJ, de Leeuw FE, Thijs V, Greisenegger S, Vemmos K, Lichy C, Bereczki D, Csiba L, Michel P, Leys D, Spengos K, Naess H, Bahar SZ, Tatlisumak T. Putaala J, et al. Stroke. 2012 Oct;43(10):2624-30. doi: 10.1161/STROKEAHA.112.662866. Epub 2012 Jul 12. Stroke. 2012. PMID: 22798330 Clinical Trial.
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