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Probing phosphoinositide functions in signaling and membrane trafficking.
Downes CP, Gray A, Lucocq JM. Downes CP, et al. Among authors: gray a. Trends Cell Biol. 2005 May;15(5):259-68. doi: 10.1016/j.tcb.2005.03.008. Trends Cell Biol. 2005. PMID: 15866030 Review.
The inositol phospholipids (PIs) comprise a family of eight species with different combinations of phosphate groups arranged around the inositol ring. ...
The inositol phospholipids (PIs) comprise a family of eight species with different combinations of phosphate groups arranged around t …
Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK.
Fyffe FA, Hawley SA, Gray A, Hardie DG. Fyffe FA, et al. Among authors: gray a. Methods Mol Biol. 2018;1732:69-86. doi: 10.1007/978-1-4939-7598-3_5. Methods Mol Biol. 2018. PMID: 29480469
Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling.
McGuire VA, Gray A, Monk CE, Santos SG, Lee K, Aubareda A, Crowe J, Ronkina N, Schwermann J, Batty IH, Leslie NR, Dean JL, O'Keefe SJ, Boothby M, Gaestel M, Arthur JS. McGuire VA, et al. Among authors: gray a. Mol Cell Biol. 2013 Nov;33(21):4152-65. doi: 10.1128/MCB.01691-12. Epub 2013 Aug 26. Mol Cell Biol. 2013. PMID: 23979601 Free PMC article.
Analysis of lipid levels in MK2/3-deficient bone marrow-derived macrophages (BMDMs) revealed a role for MK2/3 in regulating Akt activity by affecting availability of PIP3 at the membrane. These data describe a novel role for p38α-MK2/3 in regulating TLR-induced Akt …
Analysis of lipid levels in MK2/3-deficient bone marrow-derived macrophages (BMDMs) revealed a role for MK2/3 in regulating Akt activ …
PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity.
Tibarewal P, Zilidis G, Spinelli L, Schurch N, Maccario H, Gray A, Perera NM, Davidson L, Barton GJ, Leslie NR. Tibarewal P, et al. Among authors: gray a. Sci Signal. 2012 Feb 28;5(213):ra18. doi: 10.1126/scisignal.2002138. Sci Signal. 2012. PMID: 22375056
The tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) has a well-characterized lipid phosphatase activity and a poorly characterized protein phosphatase activity. ...Finally, we identified a tumor-derived PTEN mutant selectively …
The tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) has a well-characterized lipid phosphatase activi …
A screen for novel phosphoinositide 3-kinase effector proteins.
Dixon MJ, Gray A, Boisvert FM, Agacan M, Morrice NA, Gourlay R, Leslie NR, Downes CP, Batty IH. Dixon MJ, et al. Among authors: gray a. Mol Cell Proteomics. 2011 Apr;10(4):M110.003178. doi: 10.1074/mcp.M110.003178. Epub 2011 Jan 24. Mol Cell Proteomics. 2011. PMID: 21263009 Free PMC article.
The latter encompass a broad set of proteins that include the gene product of TBC1D2A, a putative Rab guanine nucleotide triphosphatase activating protein (GAP) and IQ motif containing GAP1, a potential tumor promoter. A sequence comparison of the form …
The latter encompass a broad set of proteins that include the gene product of TBC1D2A, a putative Rab guanine nucleotide triph …
Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells.
Turban S, Stretton C, Drouin O, Green CJ, Watson ML, Gray A, Ross F, Lantier L, Viollet B, Hardie DG, Marette A, Hundal HS. Turban S, et al. Among authors: gray a. J Biol Chem. 2012 Jun 8;287(24):20088-99. doi: 10.1074/jbc.M111.330746. Epub 2012 Apr 17. J Biol Chem. 2012. PMID: 22511782 Free PMC article.
Expression of a constitutively active AMPK mimicked the effects of AICAR on GU, whereas a dominant interfering AMPK or shRNA silencing of AMPK prevented AICAR-stimulated GU and Met-induced AMPK signaling but only repressed biguanide-stimulated GU by ∼20%. ...Our fin …
Expression of a constitutively active AMPK mimicked the effects of AICAR on GU, whereas a dominant interfering AMPK or shRNA s …
IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.
Dixon MJ, Gray A, Schenning M, Agacan M, Tempel W, Tong Y, Nedyalkova L, Park HW, Leslie NR, van Aalten DM, Downes CP, Batty IH. Dixon MJ, et al. Among authors: gray a. J Biol Chem. 2012 Jun 29;287(27):22483-96. doi: 10.1074/jbc.M112.352773. Epub 2012 Apr 5. J Biol Chem. 2012. PMID: 22493426 Free PMC article.
Class I phosphoinositide (PI) 3-kinases act through effector proteins whose 3-PI selectivity is mediated by a limited repertoire of structurally defined, lipid recognition domains. ...We propose that this module integrates select IQGAP proteins with PI 3-kinase signaling a …
Class I phosphoinositide (PI) 3-kinases act through effector proteins whose 3-PI selectivity is mediated by a limited repertoire of s …
Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.
Maccario H, Perera NM, Gray A, Downes CP, Leslie NR. Maccario H, et al. Among authors: gray a. J Biol Chem. 2010 Apr 23;285(17):12620-8. doi: 10.1074/jbc.M109.072280. Epub 2010 Feb 22. J Biol Chem. 2010. PMID: 20177066 Free PMC article.
Finally, we show that hyperosmotic stress increases both PTEN ubiquitination and cellular PtdInsP(3) levels well before a reduction in PTEN protein levels is observed. ...Our data indicate that ubiquitination may represent a regulated mechanism of direct reversible …
Finally, we show that hyperosmotic stress increases both PTEN ubiquitination and cellular PtdInsP(3) levels well before a reduction i …
Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake.
Green CJ, Göransson O, Kular GS, Leslie NR, Gray A, Alessi DR, Sakamoto K, Hundal HS. Green CJ, et al. Among authors: gray a. J Biol Chem. 2008 Oct 10;283(41):27653-67. doi: 10.1074/jbc.M802623200. Epub 2008 Jul 31. J Biol Chem. 2008. PMID: 18669636
Importantly, we have discovered that Akti inhibition is critically dependent upon a solvent-exposed tryptophan residue (Trp-80) that is present within the pleckstrin homology domain of all three PKB isoforms and whose mutation to an alanine (PKB(W80A)) yields an Akti-resis …
Importantly, we have discovered that Akti inhibition is critically dependent upon a solvent-exposed tryptophan residue (Trp-80) that …
Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation.
Mirshamsi S, Laidlaw HA, Ning K, Anderson E, Burgess LA, Gray A, Sutherland C, Ashford ML. Mirshamsi S, et al. Among authors: gray a. BMC Neurosci. 2004 Dec 6;5:54. doi: 10.1186/1471-2202-5-54. BMC Neurosci. 2004. PMID: 15581426 Free PMC article.
A key cellular signalling intermediate, implicated in control of food intake by these hormones, is the enzyme phosphoinositide 3-kinase. ...This hypothesis is reinforced by the finding that leptin induces actin filament depolymerization, in a PI3K dependent manner i
A key cellular signalling intermediate, implicated in control of food intake by these hormones, is the enzyme phosphoinositide 3-kina
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