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Adipogenesis and lipotoxicity: role of peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgammacoactivator-1 (PGC1).
Medina-Gomez G, Gray S, Vidal-Puig A. Medina-Gomez G, et al. Public Health Nutr. 2007 Oct;10(10A):1132-7. doi: 10.1017/S1368980007000614. Public Health Nutr. 2007. PMID: 17903321 Review.
The generation of PPARgamma knockout mice, either tissue specific or isoform specific, has provided new models to study PPARgamma's role in adipose tissue differentiation and function and have highlighted the essential role of PPARgamma in adipogenesis and lipogenesis.A se …
The generation of PPARgamma knockout mice, either tissue specific or isoform specific, has provided new models to study PPARgamma's r …
Defective peroxisomal proliferators activated receptor gamma activity due to dominant-negative mutation synergizes with hypertension to accelerate cardiac fibrosis in mice.
Kis A, Murdoch C, Zhang M, Siva A, Rodriguez-Cuenca S, Carobbio S, Lukasik A, Blount M, O'Rahilly S, Gray SL, Shah AM, Vidal-Puig A. Kis A, et al. Eur J Heart Fail. 2009 Jun;11(6):533-41. doi: 10.1093/eurjhf/hfp048. Epub 2009 Apr 24. Eur J Heart Fail. 2009. PMID: 19395708 Free PMC article.
The human lipodystrophy gene BSCL2/seipin may be essential for normal adipocyte differentiation.
Payne VA, Grimsey N, Tuthill A, Virtue S, Gray SL, Dalla Nora E, Semple RK, O'Rahilly S, Rochford JJ. Payne VA, et al. Diabetes. 2008 Aug;57(8):2055-60. doi: 10.2337/db08-0184. Epub 2008 May 5. Diabetes. 2008. PMID: 18458148 Free PMC article.
Adipose tissue expandability in the maintenance of metabolic homeostasis.
Gray SL, Vidal-Puig AJ. Gray SL, et al. Nutr Rev. 2007 Jun;65(6 Pt 2):S7-12. doi: 10.1111/j.1753-4887.2007.tb00331.x. Nutr Rev. 2007. PMID: 17605308 Review.
Sequential regulation of diacylglycerol acyltransferase 2 expression by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis.
Payne VA, Au WS, Gray SL, Nora ED, Rahman SM, Sanders R, Hadaschik D, Friedman JE, O'rahilly S, Rochford JJ. Payne VA, et al. J Biol Chem. 2007 Jul 20;282(29):21005-14. doi: 10.1074/jbc.M702871200. Epub 2007 May 14. J Biol Chem. 2007. PMID: 17504763 Free PMC article.
PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.
Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A. Medina-Gomez G, et al. PLoS Genet. 2007 Apr 27;3(4):e64. doi: 10.1371/journal.pgen.0030064. PLoS Genet. 2007. PMID: 17465682 Free PMC article.
Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice.
Gray SL, Nora ED, Grosse J, Manieri M, Stoeger T, Medina-Gomez G, Burling K, Wattler S, Russ A, Yeo GS, Chatterjee VK, O'Rahilly S, Voshol PJ, Cinti S, Vidal-Puig A. Gray SL, et al. Diabetes. 2006 Oct;55(10):2669-77. doi: 10.2337/db06-0389. Diabetes. 2006. PMID: 17003330
A family with severe insulin resistance and diabetes due to a mutation in AKT2.
George S, Rochford JJ, Wolfrum C, Gray SL, Schinner S, Wilson JC, Soos MA, Murgatroyd PR, Williams RM, Acerini CL, Dunger DB, Barford D, Umpleby AM, Wareham NJ, Davies HA, Schafer AJ, Stoffel M, O'Rahilly S, Barroso I. George S, et al. Science. 2004 May 28;304(5675):1325-8. doi: 10.1126/science.1096706. Science. 2004. PMID: 15166380 Free PMC article.
Decreased brown adipocyte recruitment and thermogenic capacity in mice with impaired peroxisome proliferator-activated receptor (P465L PPARgamma) function.
Gray SL, Dalla Nora E, Backlund EC, Manieri M, Virtue S, Noland RC, O'Rahilly S, Cortright RN, Cinti S, Cannon B, Vidal-Puig A. Gray SL, et al. Endocrinology. 2006 Dec;147(12):5708-14. doi: 10.1210/en.2006-0684. Epub 2006 Sep 15. Endocrinology. 2006. PMID: 16980437
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