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ST101 induces a novel 17 kDa APP cleavage that precludes Aβ generation in vivo.
Green KN, Khashwji H, Estrada T, Laferla FM. Green KN, et al. Ann Neurol. 2011 May;69(5):831-44. doi: 10.1002/ana.22325. Epub 2011 Mar 17. Ann Neurol. 2011. PMID: 21416488
Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity.
Akbari Y, Hitt BD, Murphy MP, Dagher NN, Tseng BP, Green KN, Golde TE, LaFerla FM. Akbari Y, et al. Biochem Biophys Res Commun. 2004 Oct 1;322(4):1145-52. doi: 10.1016/j.bbrc.2004.07.136. Biochem Biophys Res Commun. 2004. PMID: 15336962
Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease.
Oddo S, Caccamo A, Green KN, Liang K, Tran L, Chen Y, Leslie FM, LaFerla FM. Oddo S, et al. Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3046-51. doi: 10.1073/pnas.0408500102. Epub 2005 Feb 10. Proc Natl Acad Sci U S A. 2005. PMID: 15705720 Free PMC article.
Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.
Kitazawa M, Oddo S, Yamasaki TR, Green KN, LaFerla FM. Kitazawa M, et al. J Neurosci. 2005 Sep 28;25(39):8843-53. doi: 10.1523/JNEUROSCI.2868-05.2005. J Neurosci. 2005. PMID: 16192374 Free PMC article.
A dynamic relationship between intracellular and extracellular pools of Abeta.
Oddo S, Caccamo A, Smith IF, Green KN, LaFerla FM. Oddo S, et al. Am J Pathol. 2006 Jan;168(1):184-94. doi: 10.2353/ajpath.2006.050593. Am J Pathol. 2006. PMID: 16400022 Free PMC article.
M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
Caccamo A, Oddo S, Billings LM, Green KN, Martinez-Coria H, Fisher A, LaFerla FM. Caccamo A, et al. Neuron. 2006 Mar 2;49(5):671-82. doi: 10.1016/j.neuron.2006.01.020. Neuron. 2006. PMID: 16504943
Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice.
Kitazawa M, Green KN, Caccamo A, LaFerla FM. Kitazawa M, et al. Am J Pathol. 2006 Jun;168(6):1986-97. doi: 10.2353/ajpath.2006.051232. Am J Pathol. 2006. PMID: 16723713 Free PMC article.
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