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34 results
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The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells.
Greenhough A, Patsos HA, Williams AC, Paraskeva C. Greenhough A, et al. Int J Cancer. 2007 Nov 15;121(10):2172-80. doi: 10.1002/ijc.22917. Int J Cancer. 2007. PMID: 17583570
p16INK4a polymorphism: associations with tumour progression in patients with sporadic colorectal cancer.
McCloud JM, Sivakumar R, Greenhough A, Elder J, Jones PW, Deakin M, Elder JB, Fryer AA, Hoban PR. McCloud JM, et al. Among authors: greenhough a. Int J Oncol. 2004 Nov;25(5):1447-52. Int J Oncol. 2004. PMID: 15492837
Cannabinoids and cancer: potential for colorectal cancer therapy.
Patsos HA, Hicks DJ, Greenhough A, Williams AC, Paraskeva C. Patsos HA, et al. Among authors: greenhough a. Biochem Soc Trans. 2005 Aug;33(Pt 4):712-4. doi: 10.1042/BST0330712. Biochem Soc Trans. 2005. PMID: 16042581 Review.
The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2.
Patsos HA, Hicks DJ, Dobson RR, Greenhough A, Woodman N, Lane JD, Williams AC, Paraskeva C. Patsos HA, et al. Among authors: greenhough a. Gut. 2005 Dec;54(12):1741-50. doi: 10.1136/gut.2005.073403. Epub 2005 Aug 11. Gut. 2005. PMID: 16099783 Free PMC article.
Hypomethylation and aberrant expression of the glioma pathogenesis-related 1 gene in Wilms tumors.
Chilukamarri L, Hancock AL, Malik S, Zabkiewicz J, Baker JA, Greenhough A, Dallosso AR, Huang TH, Royer-Pokora B, Brown KW, Malik K. Chilukamarri L, et al. Among authors: greenhough a. Neoplasia. 2007 Nov;9(11):970-8. doi: 10.1593/neo.07661. Neoplasia. 2007. PMID: 18030365 Free PMC article.
The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment.
Greenhough A, Smartt HJ, Moore AE, Roberts HR, Williams AC, Paraskeva C, Kaidi A. Greenhough A, et al. Carcinogenesis. 2009 Mar;30(3):377-86. doi: 10.1093/carcin/bgp014. Epub 2009 Jan 9. Carcinogenesis. 2009. PMID: 19136477 Review.
HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells.
Moore AE, Greenhough A, Roberts HR, Hicks DJ, Patsos HA, Williams AC, Paraskeva C. Moore AE, et al. Among authors: greenhough a. Carcinogenesis. 2009 Oct;30(10):1796-804. doi: 10.1093/carcin/bgp183. Epub 2009 Jul 28. Carcinogenesis. 2009. PMID: 19638428
The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells.
Greenhough A, Wallam CA, Hicks DJ, Moorghen M, Williams AC, Paraskeva C. Greenhough A, et al. Oncogene. 2010 Jun 10;29(23):3398-410. doi: 10.1038/onc.2010.94. Epub 2010 Mar 29. Oncogene. 2010. PMID: 20348947 Free PMC article.
The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells.
Patsos HA, Greenhough A, Hicks DJ, Al Kharusi M, Collard TJ, Lane JD, Paraskeva C, Williams AC. Patsos HA, et al. Among authors: greenhough a. Int J Oncol. 2010 Jul;37(1):187-93. doi: 10.3892/ijo_00000666. Int J Oncol. 2010. PMID: 20514410
Colon tumour cells increase PGE(2) by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation.
Roberts HR, Smartt HJ, Greenhough A, Moore AE, Williams AC, Paraskeva C. Roberts HR, et al. Among authors: greenhough a. Carcinogenesis. 2011 Nov;32(11):1741-7. doi: 10.1093/carcin/bgr210. Epub 2011 Sep 16. Carcinogenesis. 2011. PMID: 21926111
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