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Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA.
Jensen AA, Christesen T, Bølcho U, Greenwood JR, Postorino G, Vogensen SB, Johansen TN, Egebjerg J, Bräuner-Osborne H, Clausen RP. Jensen AA, et al. Among authors: greenwood jr. J Med Chem. 2007 Aug 23;50(17):4177-85. doi: 10.1021/jm070532r. Epub 2007 Aug 2. J Med Chem. 2007. PMID: 17672447
Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes.
Friesner RA, Murphy RB, Repasky MP, Frye LL, Greenwood JR, Halgren TA, Sanschagrin PC, Mainz DT. Friesner RA, et al. Among authors: greenwood jr. J Med Chem. 2006 Oct 19;49(21):6177-96. doi: 10.1021/jm051256o. J Med Chem. 2006. PMID: 17034125
A tetrazolyl-substituted subtype-selective AMPA receptor agonist.
Vogensen SB, Frydenvang K, Greenwood JR, Postorino G, Nielsen B, Pickering DS, Ebert B, Bølcho U, Egebjerg J, Gajhede M, Kastrup JS, Johansen TN, Clausen RP, Krogsgaard-Larsen P. Vogensen SB, et al. Among authors: greenwood jr. J Med Chem. 2007 May 17;50(10):2408-14. doi: 10.1021/jm061439q. Epub 2007 Apr 25. J Med Chem. 2007. PMID: 17455929
Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid.
Frydenvang K, Pickering DS, Greenwood JR, Krogsgaard-Larsen N, Brehm L, Nielsen B, Vogensen SB, Hald H, Kastrup JS, Krogsgaard-Larsen P, Clausen RP. Frydenvang K, et al. Among authors: greenwood jr. J Med Chem. 2010 Dec 9;53(23):8354-61. doi: 10.1021/jm101218a. Epub 2010 Nov 10. J Med Chem. 2010. PMID: 21067182
Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2.
Frandsen A, Pickering DS, Vestergaard B, Kasper C, Nielsen BB, Greenwood JR, Campiani G, Fattorusso C, Gajhede M, Schousboe A, Kastrup JS. Frandsen A, et al. Among authors: greenwood jr. Mol Pharmacol. 2005 Mar;67(3):703-13. doi: 10.1124/mol.104.002931. Epub 2004 Dec 9. Mol Pharmacol. 2005. PMID: 15591246
Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site.
Kvist T, Steffensen TB, Greenwood JR, Mehrzad Tabrizi F, Hansen KB, Gajhede M, Pickering DS, Traynelis SF, Kastrup JS, Bräuner-Osborne H. Kvist T, et al. Among authors: greenwood jr. J Biol Chem. 2013 Nov 15;288(46):33124-35. doi: 10.1074/jbc.M113.480210. Epub 2013 Sep 26. J Biol Chem. 2013. PMID: 24072709 Free PMC article.
Structure-based discovery of antagonists for GluN3-containing N-methyl-D-aspartate receptors.
Kvist T, Greenwood JR, Hansen KB, Traynelis SF, Bräuner-Osborne H. Kvist T, et al. Among authors: greenwood jr. Neuropharmacology. 2013 Dec;75:324-36. doi: 10.1016/j.neuropharm.2013.08.003. Epub 2013 Aug 22. Neuropharmacology. 2013. PMID: 23973313 Free PMC article.
Glutamate receptor agonists: stereochemical aspects.
Vogensen SB, Greenwood JR, Bunch L, Clausen RP. Vogensen SB, et al. Among authors: greenwood jr. Curr Top Med Chem. 2011;11(7):887-906. doi: 10.2174/156802611795164990. Curr Top Med Chem. 2011. PMID: 21291400 Review.
The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization.
Clausen RP, Naur P, Kristensen AS, Greenwood JR, Strange M, Bräuner-Osborne H, Jensen AA, Nielsen AS, Geneser U, Ringgaard LM, Nielsen B, Pickering DS, Brehm L, Gajhede M, Krogsgaard-Larsen P, Kastrup JS. Clausen RP, et al. Among authors: greenwood jr. J Med Chem. 2009 Aug 13;52(15):4911-22. doi: 10.1021/jm900565c. J Med Chem. 2009. PMID: 19588945
N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands.
Clausen RP, Christensen C, Hansen KB, Greenwood JR, Jørgensen L, Micale N, Madsen JC, Nielsen B, Egebjerg J, Bräuner-Osborne H, Traynelis SF, Kristensen JL. Clausen RP, et al. Among authors: greenwood jr. J Med Chem. 2008 Jul 24;51(14):4179-87. doi: 10.1021/jm800025e. Epub 2008 Jun 25. J Med Chem. 2008. PMID: 18578474 Free PMC article.
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