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Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.
Alvarez-Calderon F, Gregory MA, Pham-Danis C, DeRyckere D, Stevens BM, Zaberezhnyy V, Hill AA, Gemta L, Kumar A, Kumar V, Wempe MF, Pollyea DA, Jordan CT, Serkova NJ, Graham DK, DeGregori J. Alvarez-Calderon F, et al. Among authors: gregory ma. Clin Cancer Res. 2015 Mar 15;21(6):1360-72. doi: 10.1158/1078-0432.CCR-14-2146. Epub 2014 Dec 29. Clin Cancer Res. 2015. PMID: 25547679 Free PMC article.
ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.
Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA, Wempe MF, Jordan CT, Serkova NJ, Tan AC, Hansen KC, DeGregori J. Gregory MA, et al. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6669-E6678. doi: 10.1073/pnas.1603876113. Epub 2016 Oct 10. Proc Natl Acad Sci U S A. 2016. PMID: 27791036 Free PMC article.
Targeting Glutamine Metabolism and Redox State for Leukemia Therapy.
Gregory MA, Nemkov T, Park HJ, Zaberezhnyy V, Gehrke S, Adane B, Jordan CT, Hansen KC, D'Alessandro A, DeGregori J. Gregory MA, et al. Clin Cancer Res. 2019 Jul 1;25(13):4079-4090. doi: 10.1158/1078-0432.CCR-18-3223. Epub 2019 Apr 2. Clin Cancer Res. 2019. PMID: 30940653 Free PMC article.
Rational combination of a MEK inhibitor, selumetinib, and the Wnt/calcium pathway modulator, cyclosporin A, in preclinical models of colorectal cancer.
Spreafico A, Tentler JJ, Pitts TM, Tan AC, Gregory MA, Arcaroli JJ, Klauck PJ, McManus MC, Hansen RJ, Kim J, Micel LN, Selby HM, Newton TP, McPhillips KL, Gustafson DL, Degregori JV, Messersmith WA, Winn RA, Eckhardt SG. Spreafico A, et al. Among authors: gregory ma. Clin Cancer Res. 2013 Aug 1;19(15):4149-62. doi: 10.1158/1078-0432.CCR-12-3140. Epub 2013 Jun 11. Clin Cancer Res. 2013. PMID: 23757356 Free PMC article.
107 results