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Combination of the sodium-glucose cotransporter-2 inhibitor empagliflozin with orlistat or sibutramine further improves the body-weight reduction and glucose homeostasis of obese rats fed a cafeteria diet.
Vickers SP, Cheetham SC, Headland KR, Dickinson K, Grempler R, Mayoux E, Mark M, Klein T. Vickers SP, et al. Among authors: grempler r. Diabetes Metab Syndr Obes. 2014 Jul 1;7:265-75. doi: 10.2147/DMSO.S58786. eCollection 2014. Diabetes Metab Syndr Obes. 2014. PMID: 25061325 Free PMC article.
Normalization of prandial blood glucose and improvement of glucose tolerance by liver-specific inhibition of SH2 domain containing inositol phosphatase 2 (SHIP2) in diabetic KKAy mice: SHIP2 inhibition causes insulin-mimetic effects on glycogen metabolism, gluconeogenesis, and glycolysis.
Grempler R, Zibrova D, Schoelch C, van Marle A, Rippmann JF, Redemann N. Grempler R, et al. Diabetes. 2007 Sep;56(9):2235-41. doi: 10.2337/db06-1660. Epub 2007 Jun 27. Diabetes. 2007. PMID: 17596404
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