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Cloning and expression of a human large-conductance calcium-activated potassium channel.
Dworetzky SI, Trojnacki JT, Gribkoff VK. Dworetzky SI, et al. Brain Res Mol Brain Res. 1994 Nov;27(1):189-93. doi: 10.1016/0169-328x(94)90203-8. Brain Res Mol Brain Res. 1994. PMID: 7877450
Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency.
Alavian KN, Dworetzky SI, Bonanni L, Zhang P, Sacchetti S, Mariggio MA, Onofrj M, Thomas A, Li H, Mangold JE, Signore AP, Demarco U, Demady DR, Nabili P, Lazrove E, Smith PJ, Gribkoff VK, Jonas EA. Alavian KN, et al. Among authors: gribkoff vk. Brain Res. 2012 Mar 29;1446:1-11. doi: 10.1016/j.brainres.2012.01.046. Epub 2012 Jan 28. Brain Res. 2012. PMID: 22364637 Free PMC article.
Soluble Abeta and cognitive function in aged F-344 rats and Tg2576 mice.
Lindner MD, Hogan JB, Krause RG, Machet F, Bourin C, Hodges DB Jr, Corsa JA, Barten DM, Toyn JH, Stock DA, Rose GM, Gribkoff VK. Lindner MD, et al. Behav Brain Res. 2006 Oct 2;173(1):62-75. doi: 10.1016/j.bbr.2006.06.003. Epub 2006 Jul 7. Behav Brain Res. 2006. PMID: 16828889
3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction.
Boy KM, Guernon JM, Sit SY, Xie K, Hewawasam P, Boissard CG, Dworetzky SI, Natale J, Gribkoff VK, Lodge N, Starrett JE Jr. Boy KM, et al. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5089-93. doi: 10.1016/j.bmcl.2004.07.080. Bioorg Med Chem Lett. 2004. PMID: 15380205
The therapeutic potential of neuronal KCNQ channel modulators.
Gribkoff VK. Gribkoff VK. Expert Opin Ther Targets. 2003 Dec;7(6):737-48. doi: 10.1517/14728222.7.6.737. Expert Opin Ther Targets. 2003. PMID: 14640909 Review.
(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine.
Wu YJ, Boissard CG, Greco C, Gribkoff VK, Harden DG, He H, L'Heureux A, Kang SH, Kinney GG, Knox RJ, Natale J, Newton AE, Lehtinen-Oboma S, Sinz MW, Sivarao DV, Starrett JE Jr, Sun LQ, Tertyshnikova S, Thompson MW, Weaver D, Wong HS, Zhang L, Dworetzky SI. Wu YJ, et al. J Med Chem. 2003 Jul 17;46(15):3197-200. doi: 10.1021/jm034073f. J Med Chem. 2003. PMID: 12852750
Novel openers of Ca2+-dependent large-conductance potassium channels: symmetrical pharmacophore and electrophysiological evaluation of bisphenols.
Li Y, Johnson G, Romine JL, Meanwell NA, Martin SW, Dworetzky SI, Boissard CG, Gribkoff VK, Starrett JE Jr. Li Y, et al. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1437-9. doi: 10.1016/s0960-894x(03)00156-2. Bioorg Med Chem Lett. 2003. PMID: 12668007
The synthesis and structure-activity relationships of 3-amino-4-benzylquinolin-2-ones; discovery of novel KCNQ2 channel openers.
Hewawasam P, Chen N, Ding M, Natale JT, Boissard CG, Yeola S, Gribkoff VK, Starrett J, Dworetzky SI. Hewawasam P, et al. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1615-8. doi: 10.1016/j.bmcl.2004.01.073. Bioorg Med Chem Lett. 2004. PMID: 15026035
Atropisomeric 3-(beta-hydroxyethyl)-4-arylquinolin-2-ones as Maxi-K potassium channel openers.
Vrudhula VM, Dasgupta B, Qian-Cutrone J, Kozlowski ES, Boissard CG, Dworetzky SI, Wu D, Gao Q, Kimura R, Gribkoff VK, Starrett JE Jr. Vrudhula VM, et al. J Med Chem. 2007 Mar 8;50(5):1050-7. doi: 10.1021/jm061093j. Epub 2007 Feb 3. J Med Chem. 2007. PMID: 17274609
3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR.
Romine JL, Martin SW, Meanwell NA, Gribkoff VK, Boissard CG, Dworetzky SI, Natale J, Moon S, Ortiz A, Yeleswaram S, Pajor L, Gao Q, Starrett JE Jr. Romine JL, et al. J Med Chem. 2007 Feb 8;50(3):528-42. doi: 10.1021/jm061006n. J Med Chem. 2007. PMID: 17266205
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