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Notch signaling in the vasculature.
Gridley T. Gridley T. Curr Top Dev Biol. 2010;92:277-309. doi: 10.1016/S0070-2153(10)92009-7. Curr Top Dev Biol. 2010. PMID: 20816399 Free PMC article. Review.
Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis.
Xu K, Nieuwenhuis E, Cohen BL, Wang W, Canty AJ, Danska JS, Coultas L, Rossant J, Wu MY, Piscione TD, Nagy A, Gossler A, Hicks GG, Hui CC, Henkelman RM, Yu LX, Sled JG, Gridley T, Egan SE. Xu K, et al. Am J Physiol Lung Cell Mol Physiol. 2010 Jan;298(1):L45-56. doi: 10.1152/ajplung.90550.2008. Epub 2009 Nov 6. Am J Physiol Lung Cell Mol Physiol. 2010. PMID: 19897741 Free PMC article.
Notch controls the magnitude of T helper cell responses by promoting cellular longevity.
Helbig C, Gentek R, Backer RA, de Souza Y, Derks IA, Eldering E, Wagner K, Jankovic D, Gridley T, Moerland PD, Flavell RA, Amsen D. Helbig C, et al. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9041-6. doi: 10.1073/pnas.1206044109. Epub 2012 May 21. Proc Natl Acad Sci U S A. 2012. PMID: 22615412 Free PMC article.
Coactivation of Notch allows accumulation of far greater numbers of activated CD4(+) T cells than stimulation via T-cell receptor and classic costimulation alone. Notch does not overtly affect cell cycle entry or progression of CD4(+) T cells. Instead, Notch …
Coactivation of Notch allows accumulation of far greater numbers of activated CD4(+) T cells than stimulation via T-cell recep …
Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates.
Basch ML, Brown RM 2nd, Jen HI, Semerci F, Depreux F, Edlund RK, Zhang H, Norton CR, Gridley T, Cole SE, Doetzlhofer A, Maletic-Savatic M, Segil N, Groves AK. Basch ML, et al. Among authors: gridley t. Elife. 2016 Dec 14;5:e19921. doi: 10.7554/eLife.19921. Elife. 2016. PMID: 27966429 Free PMC article.
Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epithelium.
Rodriguez S, Sickles HM, Deleonardis C, Alcaraz A, Gridley T, Lin DM. Rodriguez S, et al. Dev Biol. 2008 Feb 1;314(1):40-58. doi: 10.1016/j.ydbio.2007.10.056. Epub 2007 Nov 28. Dev Biol. 2008. PMID: 18155189 Free PMC article.
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.
Amsen D, Antov A, Jankovic D, Sher A, Radtke F, Souabni A, Busslinger M, McCright B, Gridley T, Flavell RA. Amsen D, et al. Immunity. 2007 Jul;27(1):89-99. doi: 10.1016/j.immuni.2007.05.021. Epub 2007 Jul 19. Immunity. 2007. PMID: 17658279 Free PMC article.
CD4(+) T helper cells differentiate into T helper 1 (Th1) or Th2 effector lineages, which orchestrate immunity to different types of microbes. ...By using T cell-specific gene ablation of the Notch effector RBP-J or the Notch1 and 2 receptors, we showed here …
CD4(+) T helper cells differentiate into T helper 1 (Th1) or Th2 effector lineages, which orchestrate immunity to different ty …
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