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252 results
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Exploring the dihydrodipicolinate synthase tetramer: how resilient is the dimer-dimer interface?
Griffin MD, Dobson RC, Gerrard JA, Perugini MA. Griffin MD, et al. Arch Biochem Biophys. 2010 Feb 1;494(1):58-63. doi: 10.1016/ Epub 2009 Nov 15. Arch Biochem Biophys. 2010. PMID: 19919824
Dihydrodipicolinate synthase (DHDPS) from Escherichia coli displays partial mixed inhibition with respect to its first substrate, pyruvate.
Dobson RC, Griffin MD, Roberts SJ, Gerrard JA. Dobson RC, et al. Among authors: griffin md. Biochimie. 2004 Apr-May;86(4-5):311-5. doi: 10.1016/j.biochi.2004.03.008. Biochimie. 2004. PMID: 15194235
Insight into the self-association of key enzymes from pathogenic species.
Perugini MA, Griffin MD, Smith BJ, Webb LE, Davis AJ, Handman E, Gerrard JA. Perugini MA, et al. Among authors: griffin md. Eur Biophys J. 2005 Jul;34(5):469-76. doi: 10.1007/s00249-005-0491-y. Epub 2005 Jun 25. Eur Biophys J. 2005. PMID: 15981001
The crystal structures of native and (S)-lysine-bound dihydrodipicolinate synthase from Escherichia coli with improved resolution show new features of biological significance.
Dobson RC, Griffin MD, Jameson GB, Gerrard JA. Dobson RC, et al. Among authors: griffin md. Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1116-24. doi: 10.1107/S0907444905016318. Epub 2005 Jul 20. Acta Crystallogr D Biol Crystallogr. 2005. PMID: 16041077
A structural core within apolipoprotein C-II amyloid fibrils identified using hydrogen exchange and proteolysis.
Wilson LM, Mok YF, Binger KJ, Griffin MD, Mertens HD, Lin F, Wade JD, Gooley PR, Howlett GJ. Wilson LM, et al. Among authors: griffin md. J Mol Biol. 2007 Mar 9;366(5):1639-51. doi: 10.1016/j.jmb.2006.12.040. Epub 2006 Dec 21. J Mol Biol. 2007. PMID: 17217959
Phospholipid interaction induces molecular-level polymorphism in apolipoprotein C-II amyloid fibrils via alternative assembly pathways.
Griffin MD, Mok ML, Wilson LM, Pham CL, Waddington LJ, Perugini MA, Howlett GJ. Griffin MD, et al. J Mol Biol. 2008 Jan 4;375(1):240-56. doi: 10.1016/j.jmb.2007.10.038. Epub 2007 Oct 22. J Mol Biol. 2008. PMID: 18005990
Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis.
Kefala G, Evans GL, Griffin MD, Devenish SR, Pearce FG, Perugini MA, Gerrard JA, Weiss MS, Dobson RC. Kefala G, et al. Among authors: griffin md. Biochem J. 2008 Apr 15;411(2):351-60. doi: 10.1042/BJ20071360. Biochem J. 2008. PMID: 18062777
Evolution of quaternary structure in a homotetrameric enzyme.
Griffin MD, Dobson RC, Pearce FG, Antonio L, Whitten AE, Liew CK, Mackay JP, Trewhella J, Jameson GB, Perugini MA, Gerrard JA. Griffin MD, et al. J Mol Biol. 2008 Jul 18;380(4):691-703. doi: 10.1016/j.jmb.2008.05.038. Epub 2008 May 22. J Mol Biol. 2008. PMID: 18556019
Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen.
Burgess BR, Dobson RC, Bailey MF, Atkinson SC, Griffin MD, Jameson GB, Parker MW, Gerrard JA, Perugini MA. Burgess BR, et al. Among authors: griffin md. J Biol Chem. 2008 Oct 10;283(41):27598-603. doi: 10.1074/jbc.M804231200. Epub 2008 Aug 5. J Biol Chem. 2008. PMID: 18684709
Methionine oxidation inhibits assembly and promotes disassembly of apolipoprotein C-II amyloid fibrils.
Binger KJ, Griffin MD, Howlett GJ. Binger KJ, et al. Among authors: griffin md. Biochemistry. 2008 Sep 23;47(38):10208-17. doi: 10.1021/bi8009339. Epub 2008 Aug 26. Biochemistry. 2008. PMID: 18729385
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