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High-throughput screening of enzyme libraries: in vitro evolution of a beta-galactosidase by fluorescence-activated sorting of double emulsions.
Mastrobattista E, Taly V, Chanudet E, Treacy P, Kelly BT, Griffiths AD. Mastrobattista E, et al. Among authors: griffiths ad. Chem Biol. 2005 Dec;12(12):1291-300. doi: 10.1016/j.chembiol.2005.09.016. Chem Biol. 2005. PMID: 16356846
Miniaturizing chemistry and biology in microdroplets.
Kelly BT, Baret JC, Taly V, Griffiths AD. Kelly BT, et al. Among authors: griffiths ad. Chem Commun (Camb). 2007 May 14;(18):1773-88. doi: 10.1039/b616252e. Epub 2007 Feb 23. Chem Commun (Camb). 2007. PMID: 17476389 Review.
Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents.
Briseño-Roa L, Hill J, Notman S, Sellers D, Smith AP, Timperley CM, Wetherell J, Williams NH, Williams GR, Fersht AR, Griffiths AD. Briseño-Roa L, et al. Among authors: griffiths ad. J Med Chem. 2006 Jan 12;49(1):246-55. doi: 10.1021/jm050518j. J Med Chem. 2006. PMID: 16392809
Directed evolution by in vitro compartmentalization.
Miller OJ, Bernath K, Agresti JJ, Amitai G, Kelly BT, Mastrobattista E, Taly V, Magdassi S, Tawfik DS, Griffiths AD. Miller OJ, et al. Among authors: griffiths ad. Nat Methods. 2006 Jul;3(7):561-70. doi: 10.1038/nmeth897. Nat Methods. 2006. PMID: 16791215 No abstract available.
Selective gene amplification.
Kelly BT, Griffiths AD. Kelly BT, et al. Among authors: griffiths ad. Protein Eng Des Sel. 2007 Dec;20(12):577-81. doi: 10.1093/protein/gzm060. Epub 2007 Nov 30. Protein Eng Des Sel. 2007. PMID: 18055506
Amplification of complex gene libraries by emulsion PCR.
Williams R, Peisajovich SG, Miller OJ, Magdassi S, Tawfik DS, Griffiths AD. Williams R, et al. Among authors: griffiths ad. Nat Methods. 2006 Jul;3(7):545-50. doi: 10.1038/nmeth896. Nat Methods. 2006. PMID: 16791213 No abstract available.
Determinants of cofactor binding to DNA methyltransferases: insights from a systematic series of structural variants of S-adenosylhomocysteine.
Cohen HM, Griffiths AD, Tawfik DS, Loakes D. Cohen HM, et al. Among authors: griffiths ad. Org Biomol Chem. 2005 Jan 7;3(1):152-61. doi: 10.1039/b415446k. Epub 2004 Nov 26. Org Biomol Chem. 2005. PMID: 15602611
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