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The immunological synapse of CTL contains a secretory domain and membrane bridges.
Stinchcombe JC, Bossi G, Booth S, Griffiths GM. Stinchcombe JC, et al. Among authors: griffiths gm. Immunity. 2001 Nov;15(5):751-61. doi: 10.1016/s1074-7613(01)00234-5. Immunity. 2001. PMID: 11728337
Analysis of natural killer-cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease.
Marcenaro S, Gallo F, Martini S, Santoro A, Griffiths GM, Aricó M, Moretta L, Pende D. Marcenaro S, et al. Among authors: griffiths gm. Blood. 2006 Oct 1;108(7):2316-23. doi: 10.1182/blood-2006-04-015693. Epub 2006 Jun 15. Blood. 2006. PMID: 16778144
Munc18-2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T-Lymphocytes.
Dieckmann NM, Hackmann Y, Aricò M, Griffiths GM. Dieckmann NM, et al. Among authors: griffiths gm. Traffic. 2015 Dec;16(12):1330-41. doi: 10.1111/tra.12337. Epub 2015 Nov 2. Traffic. 2015. PMID: 26771955 Free PMC article.
What's special about secretory lysosomes?
Griffiths G. Griffiths G. Semin Cell Dev Biol. 2002 Aug;13(4):279-84. doi: 10.1016/s1084-9521(02)00057-5. Semin Cell Dev Biol. 2002. PMID: 12243727 Review.
Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse.
Lee J, Dieckmann NMG, Edgar JR, Griffiths GM, Siegel RM. Lee J, et al. Among authors: griffiths gm. Immun Inflamm Dis. 2018 Jun;6(2):312-321. doi: 10.1002/iid3.219. Epub 2018 Apr 11. Immun Inflamm Dis. 2018. PMID: 29642281 Free PMC article.
Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis.
Zhao F, Cannons JL, Dutta M, Griffiths GM, Schwartzberg PL. Zhao F, et al. Among authors: griffiths gm. Immunity. 2012 Jun 29;36(6):1003-16. doi: 10.1016/j.immuni.2012.05.017. Epub 2012 Jun 7. Immunity. 2012. PMID: 22683123 Free PMC article.
Hedgehog signaling controls T cell killing at the immunological synapse.
de la Roche M, Ritter AT, Angus KL, Dinsmore C, Earnshaw CH, Reiter JF, Griffiths GM. de la Roche M, et al. Among authors: griffiths gm. Science. 2013 Dec 6;342(6163):1247-50. doi: 10.1126/science.1244689. Science. 2013. PMID: 24311692 Free PMC article.
Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse.
Gawden-Bone CM, Griffiths GM. Gawden-Bone CM, et al. Among authors: griffiths gm. Front Immunol. 2019 Apr 11;10:700. doi: 10.3389/fimmu.2019.00700. eCollection 2019. Front Immunol. 2019. PMID: 31031745 Free PMC article. Review.
Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis.
Stinchcombe JC, Randzavola LO, Angus KL, Mantell JM, Verkade P, Griffiths GM. Stinchcombe JC, et al. Among authors: griffiths gm. Curr Biol. 2015 Dec 21;25(24):3239-44. doi: 10.1016/j.cub.2015.10.028. Epub 2015 Dec 5. Curr Biol. 2015. PMID: 26670998 Free PMC article.
Actin depletion initiates events leading to granule secretion at the immunological synapse.
Ritter AT, Asano Y, Stinchcombe JC, Dieckmann NM, Chen BC, Gawden-Bone C, van Engelenburg S, Legant W, Gao L, Davidson MW, Betzig E, Lippincott-Schwartz J, Griffiths GM. Ritter AT, et al. Among authors: griffiths gm. Immunity. 2015 May 19;42(5):864-76. doi: 10.1016/j.immuni.2015.04.013. Immunity. 2015. PMID: 25992860 Free PMC article.
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