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From forest to pharmacy: Should we be depressed about a sustainable Griffonia simplicifolia (Fabaceae) seed supply chain?
Cunningham AB, Brinckmann JA, Harter DEV. Cunningham AB, et al. J Ethnopharmacol. 2021 Oct 5;278:114202. doi: 10.1016/j.jep.2021.114202. Epub 2021 May 13. J Ethnopharmacol. 2021. PMID: 33991640 Review.
ETHNOPHARMACOLOGICAL RELEVANCE: Griffonia simplicifolia D.C (Baill.) (Fabaceae) seeds are unusually high (6-20% wet weight) in 5-HTP (5-Hydroxytryptophan), a serotonin precursor widely used to treat depression. ...Wild populations in West Africa are the sole commerc …
ETHNOPHARMACOLOGICAL RELEVANCE: Griffonia simplicifolia D.C (Baill.) (Fabaceae) seeds are unusually high (6-20% wet weight) in …
Biological Activity and Metabolomics of Griffonia simplicifolia Seeds Extracted with Different Methodologies.
Mannino G, Serio G, Gaglio R, Maffei ME, Settanni L, Di Stefano V, Gentile C. Mannino G, et al. Antioxidants (Basel). 2023 Sep 1;12(9):1709. doi: 10.3390/antiox12091709. Antioxidants (Basel). 2023. PMID: 37760012 Free PMC article.
Griffonia simplicifolia, a tropical plant endemic to West Africa, is highly regarded for its significant pharmacological potential. ...Furthermore, G. simplicifolia extracts revealed antibiotic activity against Staphylococcus aureus. Our results highlight the …
Griffonia simplicifolia, a tropical plant endemic to West Africa, is highly regarded for its significant pharmacological poten …
Griffonia simplicifolia seeds extract rich in 5-hydroxy-L-tryptophan reduces infection and inflammation in a mouse model of vulvovaginal candidiasis.
Puccetti M, Di Michele A, Pagano C, Pecorari E, Coletti A, Tensi L, Pariano M, Pecorari R, Ricci M, Perioli L. Puccetti M, et al. J Pharm Pharmacol. 2025 Jul 1;77(7):933-943. doi: 10.1093/jpp/rgaf024. J Pharm Pharmacol. 2025. PMID: 40414710 Free article.
BACKGROUND: Griffonia simplicifolia seeds extracts, generally prepared by maceration, are most commonly used in food supplements intended for mental well-being promotion due to the high content of 5-hydroxy-L-tryptophan (5-HTP), direct serotonin precursor. ...METHOD …
BACKGROUND: Griffonia simplicifolia seeds extracts, generally prepared by maceration, are most commonly used in food supplemen …
Chemical Characterization and DNA Fingerprinting of Griffonia simplicifolia Baill.
Vigliante I, Mannino G, Maffei ME. Vigliante I, et al. Molecules. 2019 Mar 15;24(6):1032. doi: 10.3390/molecules24061032. Molecules. 2019. PMID: 30875930 Free PMC article.
BACKGROUND: Griffonia simplicifolia Baill. (Caesalpiniaceae) is a medicinal plant whose seeds are widely used in traditional medicine for their high content of 5-hydroxy-l-tryptophan (5-HTP), a direct precursor and enhancer of the activity of the brain hormone serot …
BACKGROUND: Griffonia simplicifolia Baill. (Caesalpiniaceae) is a medicinal plant whose seeds are widely used in traditional m …
Griffonia simplicifolia negatively affects sexual behavior in female rats.
Carnevale G, Di Viesti V, Zavatti M, Benelli A, Zanoli P. Carnevale G, et al. Phytomedicine. 2010 Oct;17(12):987-91. doi: 10.1016/j.phymed.2010.02.010. Epub 2010 Mar 31. Phytomedicine. 2010. PMID: 20359873
At present Griffonia simplicifolia is used in food supplement aimed to treat mood disorders as well as to reduce food intake and body weight. ...The present study was designed to evaluate the influence of a seed extract of the plant, dosed at 25, 50 and 100 mg/kg, o …
At present Griffonia simplicifolia is used in food supplement aimed to treat mood disorders as well as to reduce food intake a …
Griffonia simplicifolia lectins bind specifically to endothelial cells and some epithelial cells in mouse tissues.
Laitinen L. Laitinen L. Histochem J. 1987 Apr;19(4):225-34. doi: 10.1007/BF01680633. Histochem J. 1987. PMID: 3597137
The binding of Griffonia simplicifolia agglutinin-I (GSA-I) and the isolectins GSA-I-AB3 and GSA-I-B4, having affinity for some alpha-D-galactosyl and N-acetyl galactosaminyl residues was studied in different mouse tissues. ...
The binding of Griffonia simplicifolia agglutinin-I (GSA-I) and the isolectins GSA-I-AB3 and GSA-I-B4, having affinity for som …
Anxiolytic-like effect of Griffonia simplicifolia Baill. seed extract in rats.
Carnevale G, Di Viesti V, Zavatti M, Zanoli P. Carnevale G, et al. Phytomedicine. 2011 Jul 15;18(10):848-51. doi: 10.1016/j.phymed.2011.01.016. Epub 2011 Feb 25. Phytomedicine. 2011. PMID: 21353511
In spite of the modern therapeutic application of Griffonia simplicifolia seed extract in mood disorders, no scientific evidence has been provided till now. For this reason the aim of our study was to investigate the effect of Griffonia simplicifolia s …
In spite of the modern therapeutic application of Griffonia simplicifolia seed extract in mood disorders, no scientific eviden …
Griffonia simplicifolia agglutinin-2-binding glycoprotein as a novel carbohydrate antigen of human colonic carcinoma.
Nakayama J, Okano A, Maeda H, Miyachi M, Ota H, Katsuyama T, Kanai M. Nakayama J, et al. Jpn J Cancer Res. 1990 Apr;81(4):388-95. doi: 10.1111/j.1349-7006.1990.tb02580.x. Jpn J Cancer Res. 1990. PMID: 1694841 Free PMC article.
Griffonia simplicifolia agglutinin-2-binding glycoprotein (GBG) in human colonic carcinoma was examined immunochemically and histochemically, GBG was extracted from colonic carcinoma as a serum-type glycoprotein of 160 kilodaltons. ...
Griffonia simplicifolia agglutinin-2-binding glycoprotein (GBG) in human colonic carcinoma was examined immunochemically and h …
Antimetastatic Effects of a Griffonia simplicifolia Seed Extract in Osteosarcoma Cell Lines.
Bellavia D, Naselli F, Serio G, Russo PM, Costa V, De Luca A, Raimondi L, Gentile C, Caradonna F, Giavaresi G. Bellavia D, et al. Antioxidants (Basel). 2026 Feb 19;15(2):263. doi: 10.3390/antiox15020263. Antioxidants (Basel). 2026. PMID: 41750643 Free PMC article.
Recently, much attention has been paid to natural compounds capable of inducing tumor cell death, reducing tumor and metastatic activity, and interacting with selective chemotherapy targeting tumor cells. Griffonia simplicifolia, a tropical African plant, has attrac …
Recently, much attention has been paid to natural compounds capable of inducing tumor cell death, reducing tumor and metastatic activity, an …
1,014 results