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Chromosomal structure is altered by mutations that suppress or enhance position effect variegation.
Hayashi S, Ruddell A, Sinclair D, Grigliatti T. Hayashi S, et al. Among authors: grigliatti t. Chromosoma. 1990 Oct;99(6):391-400. doi: 10.1007/BF01726690. Chromosoma. 1990. PMID: 2125551
All eight Su(var) mutations examined strongly suppress the inactivation of variegating alleles of the genes white [In(l) wm4], brown [In(2R) bwVDe2] and Stubble [T(2; 3) SbV]. ...
All eight Su(var) mutations examined strongly suppress the inactivation of variegating alleles of the genes white [In(l) wm4], brown [In(2R) …
Telomeric position effect--a third silencing mechanism in eukaryotes.
Doheny JG, Mottus R, Grigliatti TA. Doheny JG, et al. Among authors: grigliatti ta. PLoS One. 2008;3(12):e3864. doi: 10.1371/journal.pone.0003864. Epub 2008 Dec 5. PLoS One. 2008. PMID: 19057646 Free PMC article.
Different patterns of gene silencing in position-effect variegation.
Lloyd VK, Dyment D, Sinclair DA, Grigliatti TA. Lloyd VK, et al. Among authors: grigliatti ta. Genome. 2003 Dec;46(6):1104-17. doi: 10.1139/g03-070. Genome. 2003. PMID: 14663529
A role for the Drosophila SU(VAR)3-9 protein in chromatin organization at the histone gene cluster and in suppression of position-effect variegation.
Ner SS, Harrington MJ, Grigliatti TA. Ner SS, et al. Among authors: grigliatti ta. Genetics. 2002 Dec;162(4):1763-74. Genetics. 2002. PMID: 12524347 Free PMC article.
Mutations in the nomad retroelement are modifiers of position-effect variegation in Drosophila melanogaster.
Whalen JH, O'Grady M, Grigliatti TA. Whalen JH, et al. Among authors: grigliatti ta. Chromosome Res. 2003;11(6):573-83. doi: 10.1023/a:1024900817776. Chromosome Res. 2003. PMID: 14516066
Identification of three histone methyltransferases in Drosophila: dG9a is a suppressor of PEV and is required for gene silencing.
Mis J, Ner SS, Grigliatti TA. Mis J, et al. Among authors: grigliatti ta. Mol Genet Genomics. 2006 Jun;275(6):513-26. doi: 10.1007/s00438-006-0116-x. Epub 2006 Apr 19. Mol Genet Genomics. 2006. PMID: 16622709
Bonus, a Drosophila TIF1 homolog, is a chromatin-associated protein that acts as a modifier of position-effect variegation.
Beckstead RB, Ner SS, Hales KG, Grigliatti TA, Baker BS, Bellen HJ. Beckstead RB, et al. Among authors: grigliatti ta. Genetics. 2005 Feb;169(2):783-94. doi: 10.1534/genetics.104.037085. Epub 2004 Nov 15. Genetics. 2005. PMID: 15545640 Free PMC article.
Suppressors of position-effect variegation in Drosophila melanogaster affect expression of the heterochromatic gene light in the absence of a chromosome rearrangement.
Clegg NJ, Honda BM, Whitehead IP, Grigliatti TA, Wakimoto B, Brock HW, Lloyd VK, Sinclair DA. Clegg NJ, et al. Among authors: grigliatti ta. Genome. 1998 Aug;41(4):495-503. Genome. 1998. PMID: 9796098
Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster.
Sinclair DA, Clegg NJ, Antonchuk J, Milne TA, Stankunas K, Ruse C, Grigliatti TA, Kassis JA, Brock HW. Sinclair DA, et al. Among authors: grigliatti ta. Genetics. 1998 Jan;148(1):211-20. Genetics. 1998. PMID: 9475733 Free PMC article.
We show that mutations in E(Pc), an unusual member of the PcG, suppress PEV of four variegating rearrangements: In(l)wm4, B(SV), T(2;3)Sb(V) and In(2R)bw(VDe2). ...
We show that mutations in E(Pc), an unusual member of the PcG, suppress PEV of four variegating rearrangements: In(l)wm4, B(SV), T(2; …
Mutagen sensitivity and suppression of position-effect variegation result from mutations in mus209, the Drosophila gene encoding PCNA.
Henderson DS, Banga SS, Grigliatti TA, Boyd JB. Henderson DS, et al. Among authors: grigliatti ta. EMBO J. 1994 Mar 15;13(6):1450-9. EMBO J. 1994. PMID: 7907981 Free PMC article.
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