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The pivotal role of hepatocytes in drug discovery.
Soars MG, McGinnity DF, Grime K, Riley RJ. Soars MG, et al. Among authors: grime k. Chem Biol Interact. 2007 May 20;168(1):2-15. doi: 10.1016/j.cbi.2006.11.002. Epub 2006 Nov 18. Chem Biol Interact. 2007. PMID: 17208208 Review.
The discovery of AZD9164, a novel muscarinic M3 antagonist.
Mete A, Bowers K, Chevalier E, Donald DK, Edwards H, Escott KJ, Ford R, Grime K, Millichip I, Teobald B, Russell V. Mete A, et al. Among authors: grime k. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7440-6. doi: 10.1016/j.bmcl.2011.10.002. Epub 2011 Oct 8. Bioorg Med Chem Lett. 2011. PMID: 22047691
Lead optimisation of pyrazoles as novel FPR1 antagonists.
Morley AD, King S, Roberts B, Lever S, Teobald B, Fisher A, Cook T, Parker B, Wenlock M, Phillips C, Grime K. Morley AD, et al. Among authors: grime k. Bioorg Med Chem Lett. 2012 Jan 1;22(1):532-6. doi: 10.1016/j.bmcl.2011.10.090. Epub 2011 Nov 4. Bioorg Med Chem Lett. 2012. PMID: 22094028
42 results