Grimm EA - Search Results

1

Bystander activity of Ad-mda7: human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism.

Chada S, Mhashilkar AM, Ramesh R, Mumm JB, Sutton RB, Bocangel D, Zheng M, Grimm EA, Ekmekcioglu S. Chada S, et al. Among authors: grimm ea. Mol Ther. 2004 Dec;10(6):1085-95. doi: 10.1016/j.ymthe.2004.08.020. Mol Ther. 2004. PMID: 15564140 Free article.

2

The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24.

Caudell EG, Mumm JB, Poindexter N, Ekmekcioglu S, Mhashilkar AM, Yang XH, Retter MW, Hill P, Chada S, Grimm EA. Caudell EG, et al. Among authors: grimm ea. J Immunol. 2002 Jun 15;168(12):6041-6. doi: 10.4049/jimmunol.168.12.6041. J Immunol. 2002. PMID: 12055212

3

PI3 kinase blockade by Ad-PTEN inhibits invasion and induces apoptosis in RGP and metastatic melanoma cells.

Stewart AL, Mhashilkar AM, Yang XH, Ekmekcioglu S, Saito Y, Sieger K, Schrock R, Onishi E, Swanson X, Mumm JB, Zumstein L, Watson GJ, Snary D, Roth JA, Grimm EA, Ramesh R, Chada S. Stewart AL, et al. Among authors: grimm ea. Mol Med. 2002 Aug;8(8):451-61. Mol Med. 2002. PMID: 12435856 Free PMC article.

4

MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells.

Mhashilkar AM, Stewart AL, Sieger K, Yang HY, Khimani AH, Ito I, Saito Y, Hunt KK, Grimm EA, Roth JA, Meyn RE, Ramesh R, Chada S. Mhashilkar AM, et al. Among authors: grimm ea. Mol Ther. 2003 Aug;8(2):207-19. doi: 10.1016/s1525-0016(03)00170-9. Mol Ther. 2003. PMID: 12907143 Free article.

5

The tumor suppressor activity of MDA-7/IL-24 is mediated by intracellular protein expression in NSCLC cells.

Sieger KA, Mhashilkar AM, Stewart A, Sutton RB, Strube RW, Chen SY, Pataer A, Swisher SG, Grimm EA, Ramesh R, Chada S. Sieger KA, et al. Among authors: grimm ea. Mol Ther. 2004 Mar;9(3):355-67. doi: 10.1016/j.ymthe.2003.11.014. Mol Ther. 2004. PMID: 15006602 Free article.

6

MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family.

Chada S, Sutton RB, Ekmekcioglu S, Ellerhorst J, Mumm JB, Leitner WW, Yang HY, Sahin AA, Hunt KK, Fuson KL, Poìndexter N, Roth JA, Ramesh R, Grimm EA, Mhashilkar AM. Chada S, et al. Among authors: grimm ea. Int Immunopharmacol. 2004 May;4(5):649-67. doi: 10.1016/j.intimp.2004.01.017. Int Immunopharmacol. 2004. PMID: 15120650 Review.

7

Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients.

Tong AW, Nemunaitis J, Su D, Zhang Y, Cunningham C, Senzer N, Netto G, Rich D, Mhashilkar A, Parker K, Coffee K, Ramesh R, Ekmekcioglu S, Grimm EA, van Wart Hood J, Merritt J, Chada S. Tong AW, et al. Among authors: grimm ea. Mol Ther. 2005 Jan;11(1):160-72. doi: 10.1016/j.ymthe.2004.09.021. Mol Ther. 2005. PMID: 15585417 Free article. Clinical Trial.

8

mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer.

Chada S, Bocangel D, Ramesh R, Grimm EA, Mumm JB, Mhashilkar AM, Zheng M. Chada S, et al. Among authors: grimm ea. Mol Ther. 2005 May;11(5):724-33. doi: 10.1016/j.ymthe.2004.12.021. Mol Ther. 2005. PMID: 15851011 Free article.

9

Human interleukin 24 (MDA-7/IL-24) protein kills breast cancer cells via the IL-20 receptor and is antagonized by IL-10.

Zheng M, Bocangel D, Doneske B, Mhashilkar A, Ramesh R, Hunt KK, Ekmekcioglu S, Sutton RB, Poindexter N, Grimm EA, Chada S. Zheng M, et al. Among authors: grimm ea. Cancer Immunol Immunother. 2007 Feb;56(2):205-15. doi: 10.1007/s00262-006-0175-1. Epub 2006 May 19. Cancer Immunol Immunother. 2007. PMID: 16710719

10

Soluble human MDA-7/IL-24: characterization of the molecular form(s) inhibiting tumor growth and stimulating monocytes.

Mumm JB, Ekmekcioglu S, Poindexter NJ, Chada S, Grimm EA. Mumm JB, et al. Among authors: grimm ea. J Interferon Cytokine Res. 2006 Dec;26(12):877-86. doi: 10.1089/jir.2006.26.877. J Interferon Cytokine Res. 2006. PMID: 17238830

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