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Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells.
Cell Rep Med. 2020 Nov 17;1(8):100142. doi: 10.1016/j.xcrm.2020.100142. Epub 2020 Oct 29.
Cell Rep Med. 2020.
PMID: 33163980
Free PMC article.
Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.
Edwards MJ, Becker KA, Gripp B, Hoffmann M, Keitsch S, Wilker B, Soddemann M, Gulbins A, Carpinteiro E, Patel SH, Wilson GC, Pöhlmann S, Walter S, Fassbender K, Ahmad SA, Carpinteiro A, Gulbins E.
Edwards MJ, et al. Among authors: gripp b.
J Biol Chem. 2020 Nov 6;295(45):15174-15182. doi: 10.1074/jbc.RA120.015249. Epub 2020 Sep 11.
J Biol Chem. 2020.
PMID: 32917722
Free PMC article.
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Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells.
Carpinteiro A, Gripp B, Hoffmann M, Pöhlmann S, Hoertel N, Edwards MJ, Kamler M, Kornhuber J, Becker KA, Gulbins E.
Carpinteiro A, et al. Among authors: gripp b.
J Biol Chem. 2021 Jan-Jun;296:100701. doi: 10.1016/j.jbc.2021.100701. Epub 2021 Apr 23.
J Biol Chem. 2021.
PMID: 33895135
Free PMC article.
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