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Page 1
Griseusin D, a new pyranonaphthoquinone derivative from a alkaphilic Nocardiopsis sp.
Li YQ, Li MG, Li W, Zhao JY, Ding ZG, Cui XL, Wen ML. Li YQ, et al. J Antibiot (Tokyo). 2007 Dec;60(12):757-61. doi: 10.1038/ja.2007.100. J Antibiot (Tokyo). 2007. PMID: 18277001
A new pyranonaphthoquinone antibiotic, griseusin D (1) was isolated from the cultural fluid of the alkaphilic Nocardiopsis sp. ...
A new pyranonaphthoquinone antibiotic, griseusin D (1) was isolated from the cultural fluid of the alkaphilic Nocardiopsis sp. ...
Griseusin C, a novel quinone derivative from a marine-derived fungus Penicillium sp.
Li X, Zheng Y, Sattler I, Lin W. Li X, et al. Arch Pharm Res. 2006 Nov;29(11):942-5. doi: 10.1007/BF02969275. Arch Pharm Res. 2006. PMID: 17146960
A novel quinone derivative, Griseusin C (1), along with a known quinone, Naphthoquinone C (2), was isolated from the lyophilized culture broth of the marine-derived fungus Penicillium sp. ...
A novel quinone derivative, Griseusin C (1), along with a known quinone, Naphthoquinone C (2), was isolated from the lyophilized cult …
Total synthesis of griseusins and elucidation of the griseusin mechanism of action.
Zhang Y, Ye Q, Ponomareva LV, Cao Y, Liu Y, Cui Z, Van Lanen SG, Voss SR, She QB, Thorson JS. Zhang Y, et al. Chem Sci. 2019 Jun 27;10(32):7641-7648. doi: 10.1039/c9sc02289a. eCollection 2019 Aug 28. Chem Sci. 2019. PMID: 31583069 Free PMC article.
A divergent modular strategy for the enantioselective total synthesis of 12 naturally-occurring griseusin type pyranonaphthoquinones and 8 structurally-similar analogues is described. ...Subsequent mechanistic studies establish, for the first time, griseusins as pot …
A divergent modular strategy for the enantioselective total synthesis of 12 naturally-occurring griseusin type pyranonaphthoquinones …
Activation and Identification of a Griseusin Cluster in Streptomyces sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods.
Beck C, Gren T, Ortiz-López FJ, Jørgensen TS, Carretero-Molina D, Martín Serrano J, Tormo JR, Oves-Costales D, Kontou EE, Mohite OS, Mingyar E, Stegmann E, Genilloud O, Weber T. Beck C, et al. Molecules. 2021 Oct 30;26(21):6580. doi: 10.3390/molecules26216580. Molecules. 2021. PMID: 34770989 Free PMC article.
The structure of the produced compound was elucidated by NMR and found to be an N-acetyl cysteine adduct of the pyranonaphtoquinone polyketide 3'-O-alpha-d-forosaminyl-(+)-griseusin A. Employing a combination of multi-omics and metabolic engineering techniques, we identifi …
The structure of the produced compound was elucidated by NMR and found to be an N-acetyl cysteine adduct of the pyranonaphtoquinone polyketi …
Synthesis of the griseusin B framework via a one-pot annulation-methylation-double deprotection-spirocyclization sequence.
Naysmith BJ, Brimble MA. Naysmith BJ, et al. Org Lett. 2013 Apr 19;15(8):2006-9. doi: 10.1021/ol400686f. Epub 2013 Apr 5. Org Lett. 2013. PMID: 23560611
A highly convergent synthesis of the griseusin B scaffold is described. The key step involves an efficient one-pot Hauser-Kraus annulation-methylation-double deprotection-spirocyclization sequence that directly affords the target parent tetracyclic ring system....
A highly convergent synthesis of the griseusin B scaffold is described. The key step involves an efficient one-pot Hauser-Kraus annul …
A divergent enantioselective strategy for the synthesis of griseusins.
Zhang Y, Ye Q, Wang X, She QB, Thorson JS. Zhang Y, et al. Angew Chem Int Ed Engl. 2015 Sep 14;54(38):11219-22. doi: 10.1002/anie.201505022. Epub 2015 Jul 31. Angew Chem Int Ed Engl. 2015. PMID: 26230189 Free PMC article.
The first enantioselective total synthesis of griseusin A, griseusin C, 4'-deacetyl-griseusin A, and two non-native counterparts in 11-14 steps is reported. ...Colorectal cancer cell cytotoxicities of the final products highlight the impact of the griseusi …
The first enantioselective total synthesis of griseusin A, griseusin C, 4'-deacetyl-griseusin A, and two non-native cou …
3'-O-alpha-D-forosaminyl-(+)-griseusin A from Streptomyces griseus.
Maruyama M, Nishida C, Takahashi Y, Naganawa H, Hamada M, Takeuchi T. Maruyama M, et al. J Antibiot (Tokyo). 1994 Aug;47(8):952-4. doi: 10.7164/antibiotics.47.952. J Antibiot (Tokyo). 1994. PMID: 7928686 Free article. No abstract available.
Cloning, sequencing, and analysis of the griseusin polyketide synthase gene cluster from Streptomyces griseus.
Yu TW, Bibb MJ, Revill WP, Hopwood DA. Yu TW, et al. J Bacteriol. 1994 May;176(9):2627-34. doi: 10.1128/jb.176.9.2627-2634.1994. J Bacteriol. 1994. PMID: 8169211 Free PMC article.
Replacement of the gris genes with a marker gene in the S. griseus genome by using a single-stranded suicide vector propagated in Escherichia coli resulted in loss of the ability to produce griseusins A and B, showing that the five gris genes do indeed encode the type II …
Replacement of the gris genes with a marker gene in the S. griseus genome by using a single-stranded suicide vector propagated in Escherichi …
Bioassay-guided isolation of antibacterial and cytotoxic compounds from the mesophilic Actinomycete M-33-5.
Urgen M, Kocabaş F, Nalbantsoy A, Kocabas EH, Uzel A, Bedir E. Urgen M, et al. Nat Prod Commun. 2010 Feb;5(2):249-52. Nat Prod Commun. 2010. PMID: 20334137
By using chromatographic methods, two bioactive compounds were isolated and their structures were determined by spectral methods to be 4'-deacetyl griseusin A and griseusin A. The MIC values of griseusin A and 4'-deacetyl griseusin A against MRSA and E …
By using chromatographic methods, two bioactive compounds were isolated and their structures were determined by spectral methods to be 4'-de …
Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis.
Haji N, Faizi M, Koutentis PA, Carty MP, Aldabbagh F. Haji N, et al. Molecules. 2023 Jul 4;28(13):5202. doi: 10.3390/molecules28135202. Molecules. 2023. PMID: 37446864 Free PMC article. Review.
Compounds with very strong correlations to known TrxR inhibitors had inverse correlations to the expression of both reductase enzymes, NQO1 and TrxR, including naphtho[2,3-b][1,4]oxazepane-6,11-diones, benzo[a]carbazole-1,4-diones, pyranonaphthoquinones (including kalafungin, nan …
Compounds with very strong correlations to known TrxR inhibitors had inverse correlations to the expression of both reductase enzymes, NQO1 …
22 results