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Year Number of Results
1949 1
1976 1
1978 1
1979 3
1980 3
1981 1
1983 2
1987 1
1988 1
1989 3
1990 2
1991 3
1992 1
1993 8
1994 4
1995 6
1996 6
1997 2
1998 11
1999 2
2000 11
2001 14
2002 11
2003 13
2004 14
2005 8
2006 35
2007 75
2008 87
2009 109
2010 132
2011 158
2012 156
2013 174
2014 190
2015 189
2016 231
2017 223
2018 240
2019 217
2020 46
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2,131 results
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Page 1
Modifiers of GRN-Associated Frontotemporal Lobar Degeneration.
Wauters E, et al. Trends Mol Med 2017 - Review. PMID 28890134
Heterozygous loss-of-function (LOF) mutations in the human progranulin gene (GRN) cause frontotemporal lobar degeneration (FTLD) by a mechanism of haploinsufficiency. ...Multiple studies have demonstrated the heterogeneity in clinical presentation and wide variability in age of onset in patients carrying a GRN LOF mutation. ...
Heterozygous loss-of-function (LOF) mutations in the human progranulin gene (GRN) cause frontotemporal lobar degeneration (FTLD) by a …
Using ATAC-seq and RNA-seq to increase resolution in GRN connectivity.
Lowe EK, et al. Methods Cell Biol 2019 - Review. PMID 30948003
Echinoderms have some of the most complete reconstructed developmental gene regulatory networks (GRN) of any embryo, accounting for the formation of most embryo tissues and organs. ...Differential RNA-seq, combined with perturbation analysis, allows for genome-wide reconstruction of a GRN around given regulators; however, this level of resolution cannot determine direct interactions. ...
Echinoderms have some of the most complete reconstructed developmental gene regulatory networks (GRN) of any embryo, accounting for t …
Gray matter changes in asymptomatic C9orf72 and GRN mutation carriers.
Popuri K, et al. Neuroimage Clin 2018. PMID 29845007 Free PMC article.
Clinically asymptomatic subjects from families with C9orf72 mutation (15 mutation carriers, C9orf72+; and 23 non-carriers, C9orf72-) and GRN mutations (9 mutation carriers, GRN+; and 15 non-carriers, GRN-) underwent structural neuroimaging (MRI). ...Mean age of C9orf72+ and C9orf72- were 42.6 ± 11.3 and 49.7 ± 15.5 years, respectively; while GRN+ and GRN- groups were 50.1 ± 8.7 and 53.2 ± 11.2 years respectively. ...
Clinically asymptomatic subjects from families with C9orf72 mutation (15 mutation carriers, C9orf72+; and 23 non-carriers, C9orf72-) and …
NAMPT, GRN, and SERPINE1 signature as predictor of disease progression and survival in gliomas.
Vachher M, et al. J Cell Biochem 2019. PMID 31710121
NAMPT, GRN, SERPINE1, and IL6 showed reduced OS as well as worst DFS for patients having higher mRNA expression in LGG. Increased expression of CCL2 showed worst OS in LGG patients while resistin (RETN) and GRN showed the worst OS in GBM patients. ...NAMPT, GRN, SERPINE1, CCL2, and RETN expression were found to be correlated with each other in gliomas. Finally, NAMPT, GRN, and SERPINE1 were also found to be upregulated using immunohistochemistry in a lower grade and high grade gliomas as compared to normal cells. ...
NAMPT, GRN, SERPINE1, and IL6 showed reduced OS as well as worst DFS for patients having higher mRNA expression in LGG. Increased exp …
A novel frameshift GRN mutation results in frontotemporal lobar degeneration with a distinct clinical phenotype in two siblings: case report and literature review.
Hosaka T, et al. BMC Neurol 2017 - Review. PMID 28915852 Free PMC article.
BACKGROUND: Progranulin gene (GRN) mutations are major causes of frontotemporal lobar degeneration. To date, 68 pathogenic GRN mutations have been identified. ...Moreover, some GRN mutations manifest with familial phenotypic heterogeneity. Here, we present a novel GRN mutation resulting in frontotemporal lobar degeneration with a distinct clinical phenotype, and we review reports of GRN mutations associated with familial phenotypic heterogeneity. ...
BACKGROUND: Progranulin gene (GRN) mutations are major causes of frontotemporal lobar degeneration. To date, 68 pathogenic GRN
Peripheral GRN mRNA and Serum Progranulin Levels as a Potential Indicator for Both the Presence of Splice Site Mutations and Individuals at Risk for Frontotemporal Dementia.
Guven G, et al. J Alzheimers Dis 2019. PMID 30475763 Free PMC article.
In this study, our aim was to test whether the presence of specific GRN splice site mutations (c.- 8+2T>G and c.708+6_9del), could be predicted by peripheral mRNA or protein GRN levels, by studying affected and asymptomatic individuals from FTD families. ...Both inferences suggest a potential use of peripheral GRN mRNA or serum PGRN levels as biomarkers for families with FTD....
In this study, our aim was to test whether the presence of specific GRN splice site mutations (c.- 8+2T>G and c.708+6_9del), could …
GRN Frontotemporal Dementia.
Hsiung GYR and Feldman HH. GeneReviews®. University of Washington, Seattle 1993–2020 - Review. PMID 20301545 Free Books and Documents.
DIAGNOSIS/TESTING: The diagnosis of GRN-FTD is established in a proband with suggestive findings and a heterozygous pathogenic variant in GRN identified by molecular genetic testing. ...GENETIC COUNSELING: GRN-FTD is inherited in an autosomal dominant manner. About 95% of individuals diagnosed with GRN-FTD have an affected parent. ...
DIAGNOSIS/TESTING: The diagnosis of GRN-FTD is established in a proband with suggestive findings and a heterozygous pathogenic varian …
Extended FTLD pedigree segregating a Belgian GRN-null mutation: neuropathological heterogeneity in one family.
Sieben A, et al. Alzheimers Res Ther 2018 - Review. PMID 29370838 Free PMC article.
BACKGROUND: In this paper, we describe the clinical and neuropathological findings of nine members of the Belgian progranulin gene (GRN) founder family. ...We report our comparison of our data with the published clinical and neuropathological characteristics of other GRN mutations as well as other frontotemporal lobar degeneration (FTLD) syndromes, and we present a review of the literature. ...
BACKGROUND: In this paper, we describe the clinical and neuropathological findings of nine members of the Belgian progranulin gene (GRN
Novel GRN Mutations in Patients with Corticobasal Syndrome.
Taghdiri F, et al. Sci Rep 2016. PMID 26961809 Free PMC article.
Loss-of-function GRN mutations lead to GRN haploinsufficiency and consequently neurodegeneration with significant heterogeneity in clinical presentation of various syndromes. ...The absence of the mutant allele in the RT-PCR product was only observed for the sample with 2 bp insertion in GRN. In contrast, the allele with 12 bp deletion in GRN was not down-regulated at the RNA level and did not segregate with FTLD in the family. ...
Loss-of-function GRN mutations lead to GRN haploinsufficiency and consequently neurodegeneration with significant heterogeneit …
Upregulation of microRNA-140-3p inhibits epithelial-mesenchymal transition, invasion, and metastasis of hepatocellular carcinoma through inactivation of the MAPK signaling pathway by targeting GRN.
Zhang QY, et al. J Cell Biochem 2019. PMID 31044454
The target relationship between miR-140-3p and GRN was analyzed. Small interfering RNA (siRNA) against granulin (GRN) was synthesized. ...GRN was highlighted as an upregulated gene in HCC. GRN was a target gene of miR-140-3p. Elevation of miR-140-3p or inhibition of GRN restrained the EMT process and suppressed the HCC cell migration and invasion. ...
The target relationship between miR-140-3p and GRN was analyzed. Small interfering RNA (siRNA) against granulin (GRN) was synt …
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