Groffen AJ - Search Results

1

DOC2A and DOC2B are sensors for neuronal activity with unique calcium-dependent and kinetic properties.

Groffen AJ, Friedrich R, Brian EC, Ashery U, Verhage M. Groffen AJ, et al. J Neurochem. 2006 May;97(3):818-33. doi: 10.1111/j.1471-4159.2006.03755.x. Epub 2006 Mar 3. J Neurochem. 2006. PMID: 16515538 Free article.

2

Ca(2+)-induced recruitment of the secretory vesicle protein DOC2B to the target membrane.

Groffen AJ, Brian EC, Dudok JJ, Kampmeijer J, Toonen RF, Verhage M. Groffen AJ, et al. J Biol Chem. 2004 May 28;279(22):23740-7. doi: 10.1074/jbc.M400731200. Epub 2004 Mar 21. J Biol Chem. 2004. PMID: 15033971 Free article.

3

Differential distribution and regulation of expression of synaptosomal-associated protein of 25 kDa isoforms in the Xenopus pituitary gland and brain.

Kolk SM, Groffen AJ, Tuinhof R, Ouwens DT, Cools AR, Jenks BG, Verhage M, Roubos EW. Kolk SM, et al. Among authors: groffen aj. Neuroscience. 2004;128(3):531-43. doi: 10.1016/j.neuroscience.2004.06.059. Neuroscience. 2004. PMID: 15381282

4

Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain.

Groffen AJ, Jacobsen L, Schut D, Verhage M. Groffen AJ, et al. J Neurochem. 2005 Feb;92(3):554-68. doi: 10.1111/j.1471-4159.2004.02890.x. J Neurochem. 2005. PMID: 15659226 Free article.

5

DOC2B acts as a calcium switch and enhances vesicle fusion.

Friedrich R, Groffen AJ, Connell E, van Weering JR, Gutman O, Henis YI, Davletov B, Ashery U. Friedrich R, et al. Among authors: groffen aj. J Neurosci. 2008 Jul 2;28(27):6794-806. doi: 10.1523/JNEUROSCI.0538-08.2008. J Neurosci. 2008. PMID: 18596155 Free PMC article.

6

Chronic activation of the 5-HT(2) receptor reduces 5-HT neurite density as studied in organotypic slice cultures.

Dudok JJ, Groffen AJ, Witter MP, Voorn P, Verhage M. Dudok JJ, et al. Among authors: groffen aj. Brain Res. 2009 Dec 11;1302:1-9. doi: 10.1016/j.brainres.2009.08.071. Epub 2009 Sep 1. Brain Res. 2009. PMID: 19728996

7

Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release.

Groffen AJ, Martens S, Díez Arazola R, Cornelisse LN, Lozovaya N, de Jong AP, Goriounova NA, Habets RL, Takai Y, Borst JG, Brose N, McMahon HT, Verhage M. Groffen AJ, et al. Science. 2010 Mar 26;327(5973):1614-8. doi: 10.1126/science.1183765. Epub 2010 Feb 11. Science. 2010. PMID: 20150444 Free PMC article.

8

Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?

Walter AM, Groffen AJ, Sørensen JB, Verhage M. Walter AM, et al. Among authors: groffen aj. Trends Neurosci. 2011 Sep;34(9):487-97. doi: 10.1016/j.tins.2011.07.003. Epub 2011 Aug 9. Trends Neurosci. 2011. PMID: 21831459 Review.

9

Deletion of Munc18-1 in 5-HT neurons results in rapid degeneration of the 5-HT system and early postnatal lethality.

Dudok JJ, Groffen AJ, Toonen RF, Verhage M. Dudok JJ, et al. Among authors: groffen aj. PLoS One. 2011;6(11):e28137. doi: 10.1371/journal.pone.0028137. Epub 2011 Nov 29. PLoS One. 2011. PMID: 22140524 Free PMC article.

10

Doc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivity.

Ramalingam L, Oh E, Yoder SM, Brozinick JT, Kalwat MA, Groffen AJ, Verhage M, Thurmond DC. Ramalingam L, et al. Among authors: groffen aj. Diabetes. 2012 Oct;61(10):2424-32. doi: 10.2337/db11-1525. Epub 2012 Jun 14. Diabetes. 2012. PMID: 22698913 Free PMC article.

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