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Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation.
Groh V, Wu J, Yee C, Spies T. Groh V, et al. Nature. 2002 Oct 17;419(6908):734-8. doi: 10.1038/nature01112. Nature. 2002. PMID: 12384702
Control of Tumor Initiation by NKG2D Naturally Expressed on Ovarian Cancer Cells.
Cai X, Caballero-Benitez A, Gewe MM, Jenkins IC, Drescher CW, Strong RK, Spies T, Groh V. Cai X, et al. Among authors: groh v. Neoplasia. 2017 Jun;19(6):471-482. doi: 10.1016/j.neo.2017.03.005. Epub 2017 May 9. Neoplasia. 2017. PMID: 28499126 Free PMC article.
Autonomous stimulation of cancer cell plasticity by the human NKG2D lymphocyte receptor coexpressed with its ligands on cancer cells.
Cai X, Dai Z, Reeves RS, Caballero-Benitez A, Duran KL, Delrow JJ, Porter PL, Spies T, Groh V. Cai X, et al. Among authors: groh v. PLoS One. 2014 Oct 7;9(10):e108942. doi: 10.1371/journal.pone.0108942. eCollection 2014. PLoS One. 2014. PMID: 25291178 Free PMC article.
Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells.
Benitez AC, Dai Z, Mann HH, Reeves RS, Margineantu DH, Gooley TA, Groh V, Spies T. Benitez AC, et al. Among authors: groh v. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4081-6. doi: 10.1073/pnas.1018603108. Epub 2011 Feb 14. Proc Natl Acad Sci U S A. 2011. PMID: 21321202 Free PMC article.
Crystal structure of a gammadelta T-cell receptor specific for the human MHC class I homolog MICA.
Xu B, Pizarro JC, Holmes MA, McBeth C, Groh V, Spies T, Strong RK. Xu B, et al. Among authors: groh v. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2414-9. doi: 10.1073/pnas.1015433108. Epub 2011 Jan 24. Proc Natl Acad Sci U S A. 2011. PMID: 21262824 Free PMC article.
Human γδ T cells of the V(δ)1 subset predominate in intestinal epithelia and respond to MICA and MICB (MHC class I chain-related, A and B; MIC) self-antigens, mediating responses to tumorigenesis or viral infection. The crystal structure of an MIC-reactive V(δ)1 γδ …
Human γδ T cells of the V(δ)1 subset predominate in intestinal epithelia and respond to MICA and MICB (MHC class I chain-related, A a …
NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease.
Hanaoka N, Jabri B, Dai Z, Ciszewski C, Stevens AM, Yee C, Nakakuma H, Spies T, Groh V. Hanaoka N, et al. Among authors: groh v. J Immunol. 2010 Nov 15;185(10):5732-42. doi: 10.4049/jimmunol.1002092. Epub 2010 Oct 6. J Immunol. 2010. PMID: 20926796 Free PMC article.
Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands.
Kaiser BK, Yim D, Chow IT, Gonzalez S, Dai Z, Mann HH, Strong RK, Groh V, Spies T. Kaiser BK, et al. Among authors: groh v. Nature. 2007 May 24;447(7143):482-6. doi: 10.1038/nature05768. Epub 2007 May 9. Nature. 2007. PMID: 17495932
Efficient cross-priming of tumor antigen-specific T cells by dendritic cells sensitized with diverse anti-MICA opsonized tumor cells.
Groh V, Li YQ, Cioca D, Hunder NN, Wang W, Riddell SR, Yee C, Spies T. Groh V, et al. Proc Natl Acad Sci U S A. 2005 May 3;102(18):6461-6. doi: 10.1073/pnas.0501953102. Epub 2005 Apr 11. Proc Natl Acad Sci U S A. 2005. PMID: 15824323 Free PMC article.
Immunostimulation by induced expression of NKG2D and its MIC ligands in HTLV-1-associated neurologic disease.
Azimi N, Jacobson S, Tanaka Y, Corey L, Groh V, Spies T. Azimi N, et al. Among authors: groh v. Immunogenetics. 2006 May;58(4):252-8. doi: 10.1007/s00251-006-0082-9. Epub 2006 Mar 28. Immunogenetics. 2006. PMID: 16568261
Soluble MICB in Plasma and Urine Explains Population Expansions of NKG2D+CD4 T Cells Inpatients with Juvenile-Onset Systemic Lupus Erythematosus.
Hamada S, Caballero-Benitez A, Duran KL, Stevens AM, Spies T, Groh V. Hamada S, et al. Among authors: groh v. Open J Immunol. 2017 Mar;7(1):1-17. doi: 10.4236/oji.2017.71001. Epub 2017 Mar 29. Open J Immunol. 2017. PMID: 28944101 Free PMC article.
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