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Effects of the hypoglycaemic drugs repaglinide and glibenclamide on ATP-sensitive potassium-channels and cytosolic calcium levels in beta TC3 cells and rat pancreatic beta cells.
Gromada J, Dissing S, Kofod H, Frøkjaer-Jensen J. Gromada J, et al. Diabetologia. 1995 Sep;38(9):1025-32. doi: 10.1007/BF00402171. Diabetologia. 1995. PMID: 8591815
ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells.
Gromada J, Ma X, Høy M, Bokvist K, Salehi A, Berggren PO, Rorsman P. Gromada J, et al. Diabetes. 2004 Dec;53 Suppl 3:S181-9. doi: 10.2337/diabetes.53.suppl_3.s181. Diabetes. 2004. PMID: 15561909
Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors.
Ma X, Zhang Y, Gromada J, Sewing S, Berggren PO, Buschard K, Salehi A, Vikman J, Rorsman P, Eliasson L. Ma X, et al. Mol Endocrinol. 2005 Jan;19(1):198-212. doi: 10.1210/me.2004-0059. Epub 2004 Sep 30. Mol Endocrinol. 2005. PMID: 15459251
Secretory phospholipase A2 is released from pancreatic beta-cells and stimulates insulin secretion via inhibition of ATP-dependent K+ channels.
Juhl K, Efanov AM, Olsen HL, Gromada J. Juhl K, et al. Biochem Biophys Res Commun. 2003 Oct 17;310(2):274-9. doi: 10.1016/j.bbrc.2003.09.018. Biochem Biophys Res Commun. 2003. PMID: 14521906
The imidazoline NNC77-0020 affects glucose-dependent insulin, glucagon and somatostatin secretion in mouse pancreatic islets.
Høy M, Olsen HL, Bokvist K, Petersen JS, Gromada J. Høy M, et al. Naunyn Schmiedebergs Arch Pharmacol. 2003 Oct;368(4):284-93. doi: 10.1007/s00210-003-0797-1. Epub 2003 Sep 6. Naunyn Schmiedebergs Arch Pharmacol. 2003. PMID: 13680090
Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells.
Olsen HL, Hoy M, Zhang W, Bertorello AM, Bokvist K, Capito K, Efanov AM, Meister B, Thams P, Yang SN, Rorsman P, Berggren PO, Gromada J. Olsen HL, et al. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5187-92. doi: 10.1073/pnas.0931282100. Epub 2003 Apr 16. Proc Natl Acad Sci U S A. 2003. PMID: 12700357 Free PMC article.
Imidazoline NNC77-0074 stimulates Ca2+-evoked exocytosis in INS-1E cells by a phospholipase A2-dependent mechanism.
Olsen HL, Nørby PL, Høy M, Spee P, Thams P, Capito K, Petersen JS, Gromada J. Olsen HL, et al. Biochem Biophys Res Commun. 2003 Apr 18;303(4):1148-51. doi: 10.1016/s0006-291x(03)00505-9. Biochem Biophys Res Commun. 2003. PMID: 12684056
Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells.
Høy M, Olsen HL, Andersen HS, Bokvist K, Buschard K, Hansen J, Jacobsen P, Petersen JS, Rorsman P, Gromada J. Høy M, et al. Eur J Pharmacol. 2003 Apr 11;466(1-2):213-21. doi: 10.1016/s0014-2999(03)01537-1. Eur J Pharmacol. 2003. PMID: 12679159
cPLA2alpha-evoked formation of arachidonic acid and lysophospholipids is required for exocytosis in mouse pancreatic beta-cells.
Juhl K, Høy M, Olsen HL, Bokvist K, Efanov AM, Hoffmann EK, Gromada J. Juhl K, et al. Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E73-81. doi: 10.1152/ajpendo.00086.2003. Epub 2003 Mar 18. Am J Physiol Endocrinol Metab. 2003. PMID: 12644445
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