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Evaluation of the intestinal toxicity and transport of xenobiotics utilizing precision-cut slices.
Niu X, de Graaf IA, Groothuis GM. Niu X, et al. Among authors: groothuis gm. Xenobiotica. 2013 Jan;43(1):73-83. doi: 10.3109/00498254.2012.729870. Epub 2012 Oct 30. Xenobiotica. 2013. PMID: 23106567 Review.
LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process.
Elferink MG, Olinga P, Draaisma AL, Merema MT, Faber KN, Slooff MJ, Meijer DK, Groothuis GM. Elferink MG, et al. Among authors: groothuis gm. Am J Physiol Gastrointest Liver Physiol. 2004 Nov;287(5):G1008-16. doi: 10.1152/ajpgi.00071.2004. Epub 2004 Jun 17. Am J Physiol Gastrointest Liver Physiol. 2004. PMID: 15205115
Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu.
van de Bovenkamp M, Groothuis GM, Draaisma AL, Merema MT, Bezuijen JI, van Gils MJ, Meijer DK, Friedman SL, Olinga P. van de Bovenkamp M, et al. Among authors: groothuis gm. Toxicol Sci. 2005 May;85(1):632-8. doi: 10.1093/toxsci/kfi127. Epub 2005 Feb 23. Toxicol Sci. 2005. PMID: 15728706
Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies.
van de Kerkhof EG, de Graaf IA, de Jager MH, Meijer DK, Groothuis GM. van de Kerkhof EG, et al. Among authors: groothuis gm. Drug Metab Dispos. 2005 Nov;33(11):1613-20. doi: 10.1124/dmd.105.005686. Epub 2005 Jul 28. Drug Metab Dispos. 2005. PMID: 16051733
Prediction of the pharmacokinetics of succinylated human serum albumin in man from in vivo disposition data in animals and in vitro liver slice incubations.
Proost JH, Beljaars L, Olinga P, Swart PJ, Kuipers ME, Reker-Smit C, Groothuis GM, Meijer DK. Proost JH, et al. Among authors: groothuis gm. Eur J Pharm Sci. 2006 Feb;27(2-3):123-32. doi: 10.1016/j.ejps.2005.08.014. Epub 2005 Oct 10. Eur J Pharm Sci. 2006. PMID: 16219448
Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction.
de Graaf IA, de Kanter R, de Jager MH, Camacho R, Langenkamp E, van de Kerkhof EG, Groothuis GM. de Graaf IA, et al. Among authors: groothuis gm. Drug Metab Dispos. 2006 Apr;34(4):591-9. doi: 10.1124/dmd.105.006726. Epub 2006 Jan 13. Drug Metab Dispos. 2006. PMID: 16415126
Precision-cut fibrotic rat liver slices as a new model to test the effects of anti-fibrotic drugs in vitro.
van de Bovenkamp M, Groothuis GM, Meijer DK, Olinga P. van de Bovenkamp M, et al. Among authors: groothuis gm. J Hepatol. 2006 Nov;45(5):696-703. doi: 10.1016/j.jhep.2006.04.009. Epub 2006 May 26. J Hepatol. 2006. PMID: 16828918
Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with ussing chamber preparations.
van de Kerkhof EG, Ungell AL, Sjöberg AK, de Jager MH, Hilgendorf C, de Graaf IA, Groothuis GM. van de Kerkhof EG, et al. Among authors: groothuis gm. Drug Metab Dispos. 2006 Nov;34(11):1893-902. doi: 10.1124/dmd.106.011148. Epub 2006 Aug 16. Drug Metab Dispos. 2006. PMID: 16914511
Cryopreservation of rat precision-cut liver and kidney slices by rapid freezing and vitrification.
de Graaf IA, Draaisma AL, Schoeman O, Fahy GM, Groothuis GM, Koster HJ. de Graaf IA, et al. Among authors: groothuis gm. Cryobiology. 2007 Feb;54(1):1-12. doi: 10.1016/j.cryobiol.2006.09.002. Epub 2006 Dec 12. Cryobiology. 2007. PMID: 17166492
Detection of xenobiotic-induced DNA damage by the comet assay applied to human and rat precision-cut liver slices.
Plazar J, Hreljac I, Pirih P, Filipic M, Groothuis GM. Plazar J, et al. Among authors: groothuis gm. Toxicol In Vitro. 2007 Sep;21(6):1134-42. doi: 10.1016/j.tiv.2007.02.012. Epub 2007 Mar 12. Toxicol In Vitro. 2007. PMID: 17459656
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